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MedKoo Cat#: 584496 | Name: JL 18

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JL 18 is a pyridobenzodiazepine derivative bioisoster of clozapine.

Chemical Structure

JL 18
JL 18
CAS#147395-65-1

Theoretical Analysis

MedKoo Cat#: 584496

Name: JL 18

CAS#: 147395-65-1

Chemical Formula: C18H21N5

Exact Mass: 307.1797

Molecular Weight: 307.40

Elemental Analysis: C, 70.33; H, 6.89; N, 22.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JL 18; JL-18; JL18
IUPAC/Chemical Name
8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine
InChi Key
MMCMKWDIEUZMQB-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)
SMILES Code
CN1CCN(C2=NC3=CC=CN=C3NC4=CC=C(C)C=C24)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 307.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shionoya T, Mizuno M, Tsukamoto T, Ikeda K, Seki H, Kojima K, Shibata M, Kawamura I, Sudo Y, Mizutani Y. High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment. J Phys Chem B. 2018 Jul 12;122(27):6945-6953. doi: 10.1021/acs.jpcb.8b04894. Epub 2018 Jun 27. PubMed PMID: 29893559. 2: Tsukamoto T, Mizutani K, Hasegawa T, Takahashi M, Honda N, Hashimoto N, Shimono K, Yamashita K, Yamamoto M, Miyauchi S, Takagi S, Hayashi S, Murata T, Sudo Y. X-ray Crystallographic Structure of Thermophilic Rhodopsin: IMPLICATIONS FOR HIGH THERMAL STABILITY AND OPTOGENETIC FUNCTION. J Biol Chem. 2016 Jun 3;291(23):12223-32. doi: 10.1074/jbc.M116.719815. Epub 2016 Apr 18. PubMed PMID: 27129243; PubMed Central PMCID: PMC4933271. 3: Murugapiran SK, Huntemann M, Wei CL, Han J, Detter JC, Han C, Erkkila TH, Teshima H, Chen A, Kyrpides N, Mavrommatis K, Markowitz V, Szeto E, Ivanova N, Pagani I, Pati A, Goodwin L, Peters L, Pitluck S, Lam J, McDonald AI, Dodsworth JA, Woyke T, Hedlund BP. Thermus oshimai JL-2 and T. thermophilus JL-18 genome analysis illuminates pathways for carbon, nitrogen, and sulfur cycling. Stand Genomic Sci. 2013 Feb 25;7(3):449-68. doi: 10.4056/sigs.3667269. eCollection 2013. PubMed PMID: 24019992; PubMed Central PMCID: PMC3764938. 4: Murugapiran SK, Huntemann M, Wei CL, Han J, Detter JC, Han CS, Erkkila TH, Teshima H, Chen A, Kyrpides N, Mavrommatis K, Markowitz V, Szeto E, Ivanova N, Pagani I, Lam J, McDonald AI, Dodsworth JA, Pati A, Goodwin L, Peters L, Pitluck S, Woyke T, Hedlund BP. Whole Genome Sequencing of Thermus oshimai JL-2 and Thermus thermophilus JL-18, Incomplete Denitrifiers from the United States Great Basin. Genome Announc. 2013 Jan;1(1). pii: e00106-12. doi: 10.1128/genomeA.00106-12. Epub 2013 Jan 24. PubMed PMID: 23405355; PubMed Central PMCID: PMC3569359. 5: Morishita H, Shibata K, Sakata N, Kita S, Katsuragi T. A new approach to finding specific dopamine D4 receptor agonists. Eur J Pharmacol. 2005 Jun 1;516(2):145-50. PubMed PMID: 15922324. 6: Hadj Tahar A, Bélanger N, Bangassoro E, Grégoire L, Bédard PJ. Antidyskinetic effect of JL-18, a clozapine analog, in parkinsonian monkeys. Eur J Pharmacol. 2000 Jul 7;399(2-3):183-6. PubMed PMID: 10884518. 7: Morishita H, Katsuragi T. Existence and pharmacological properties of dopamine D4 receptors in guinea pig vas deferens. Eur J Pharmacol. 1999 Jun 18;374(2):255-61. PubMed PMID: 10422767. 8: Carey GJ, Bergman J. Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs. Psychopharmacology (Berl). 1997 Aug;132(3):261-9. PubMed PMID: 9292626. 9: Liégeois JF, Bruhwyler J, Damas J, Rogister F, Masereel B, Geczy J, Delarge J. Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor. Eur J Pharmacol. 1995 Feb 6;273(3):R1-3. PubMed PMID: 7737323.

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