Synonym
Licuraside; Liquirazide;
IUPAC/Chemical Name
(E)-1-(4-(((2S,3R,4S,5S,6R)-3-(((2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
InChi Key
NIZFPXZQERMCLE-KVFWHIKKSA-N
InChi Code
InChI=1S/C26H30O13/c27-10-19-20(32)21(33)22(39-25-23(34)26(35,11-28)12-36-25)24(38-19)37-15-6-7-16(18(31)9-15)17(30)8-3-13-1-4-14(29)5-2-13/h1-9,19-25,27-29,31-35H,10-12H2/b8-3+/t19-,20-,21+,22-,23+,24-,25+,26-/m1/s1
SMILES Code
O=C(c1c(O)cc(O[C@H]2[C@H](O[C@H]3[C@H](O)[C@](CO)(O)CO3)[C@@H](O)[C@H](O)[C@@H](CO)O2)cc1)/C=C/c4ccc(O)cc4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
550.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fu B, Li H, Wang X, Lee FS, Cui S. Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase. J Agric Food Chem. 2005 Sep 21;53(19):7408-14. PubMed PMID: 16159166.
2: Li G, Nikolic D, van Breemen RB. Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS. J Agric Food Chem. 2016 Oct 4. [Epub ahead of print] PubMed PMID: 27696846; PubMed Central PMCID: PMC5378676.
3: Huang WW, Wang MY, Shi HM, Peng Y, Peng CS, Zhang M, Li Y, Lu J, Li XB. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Arch Pharm Res. 2012 Nov;35(11):1945-52. doi: 10.1007/s12272-012-1111-x. Epub 2012 Dec 4. Erratum in: Arch Pharm Res. 2013 May;36(5):649. PubMed PMID: 23212636.
4: Wang M, Zhang M, Tang Q, Li X. Influence of honey-roasting on the main pharmacological activities and the water-soluble active glycosides of licorice. Afr J Tradit Complement Altern Med. 2011 Dec 29;9(2):189-96. eCollection 2012. PubMed PMID: 23983334; PubMed Central PMCID: PMC3746624.
5: Aida K, Tawata M, Shindo H, Onaya T, Sasaki H, Nishimura H, Chin M, Mitsuhashi H. The existence of aldose reductase inhibitors in some kampo medicines (Oriental herb prescriptions). Planta Med. 1989 Feb;55(1):22-6. PubMed PMID: 2497475.
