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MedKoo Cat#: 592707 | Name: ANTU
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ANTU is an insecticide.

Chemical Structure

ANTU
ANTU
CAS#86-88-4

Theoretical Analysis

MedKoo Cat#: 592707

Name: ANTU

CAS#: 86-88-4

Chemical Formula: C11H10N2S

Exact Mass: 202.0565

Molecular Weight: 202.28

Elemental Analysis: C, 65.32; H, 4.98; N, 13.85; S, 15.85

Price and Availability

Size Price Availability Quantity
5g USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
Naphtox; ANTU, N-(1-Naphthyl)thiourea
IUPAC/Chemical Name
1-(1-Naphthyl)-2-thiourea
InChi Key
PIVQQUNOTICCSA-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H10N2S/c12-11(14)13-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H3,12,13,14)
SMILES Code
S=C(N)NC1=C2C=CC=CC2=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 202.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sipahi E, Ustün H, Niyazi Ayoglu F. Acute effects of pentobarbital, thiopental and urethane on lung oedema induced by alpha-naphthythiourea (ANTU). Pharmacol Res. 2002 Mar;45(3):235-9. PubMed PMID: 11884221. 2: Roth RA, Ball TM. Technical grade but not recrystallized alpha-naphthylthiourea potentiates superoxide release by rat neutrophils stimulated in vitro by phorbol myristate acetate. Fundam Appl Toxicol. 1986 Aug;7(2):324-8. PubMed PMID: 3019813. 3: Davies JM, Thomas HF, Manson D. Bladder tumours among rodent operatives handling ANTU. Br Med J (Clin Res Ed). 1982 Oct 2;285(6346):927-31. PubMed PMID: 6811070; PubMed Central PMCID: PMC1499965. 4: Day BJ, Carlson GP, DeNicola DB. gamma-Glutamyltranspeptidase in rat bronchoalveolar lavage fluid as a probe of 4-ipomeanol and alpha-naphthylthiourea-induced pneumotoxicity. J Pharmacol Methods. 1990 Aug;24(1):1-8. PubMed PMID: 1976855. 5: Tutor JD, Mason CM, Dobard E, Beckerman RC, Summer WR, Nelson S. Loss of compartmentalization of alveolar tumor necrosis factor after lung injury. Am J Respir Crit Care Med. 1994 May;149(5):1107-11. PubMed PMID: 8173748. 6: Olson JW, Gebb SA, Orlinska U, Gillespie MN. Polyamine synthesis in rat lungs injured with alpha-naphthylthiourea. Toxicology. 1989 May 15;55(3):317-26. PubMed PMID: 2497556. 7: Gardaz JP, Py P, Suter PM, Junod AF. Effects of oleic acid-, alpha-naphthylthiourea-, and phorbol myristate acetate-induced microvascular damage on indexes of pulmonary endothelial function in anesthetized dogs. Am Rev Respir Dis. 1988 Jun;137(6):1350-5. PubMed PMID: 2849332. 8: Itoh K, Kimura T, Yokoi T, Itoh S, Kamataki T. Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast. Biochim Biophys Acta. 1993 May 28;1173(2):165-71. PubMed PMID: 8504165. 9: Lu Q, Harrington EO, Newton J, Casserly B, Radin G, Warburton R, Zhou Y, Blackburn MR, Rounds S. Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement. Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L755-67. doi: 10.1152/ajplung.00330.2009. Epub 2010 Mar 12. PubMed PMID: 20228181; PubMed Central PMCID: PMC2886613. 10: Boyd MR, Burka LT, Wilson BJ, Sastry BV. Development of tolerance to the pulmonary toxin, 4-ipomeanol. Toxicology. 1981;19(2):85-100. PubMed PMID: 6791310. 11: 1-Naphthylthiourea (ANTU). IARC Monogr Eval Carcinog Risk Chem Hum. 1983 Jan;30:347-57. PubMed PMID: 6413388. 12: Azoulay E, Attalah H, Yang K, Jouault H, Schlemmer B, Brun-Buisson C, Brochard L, Harf A, Delclaux C. Exacerbation by granulocyte colony-stimulating factor of prior acute lung injury: implication of neutrophils. Crit Care Med. 2002 Sep;30(9):2115-22. PubMed PMID: 12352050. 13: Smith LL. The response of the lung to foreign compounds that produce free radicals. Annu Rev Physiol. 1986;48:681-92. Review. PubMed PMID: 2423026. 14: van den Brenk HA, Kelly H, Holland KL. Effect of toxic thioureas on resistance of rats to growth in the lungs of intravenously and intratracheally seeded tumour cells. Br J Cancer. 1978 Jan;37(1):92-104. PubMed PMID: 619962; PubMed Central PMCID: PMC2009496. 15: Antu KA, Riya MP, Mishra A, Anilkumar KS, Chandrakanth CK, Tamrakar AK, Srivastava AK, Raghu KG. Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity. PLoS One. 2014 Sep 3;9(9):e105829. doi: 10.1371/journal.pone.0105829. eCollection 2014. PubMed PMID: 25184241; PubMed Central PMCID: PMC4153544. 16: Antushevich AA, Grebenyuk AN, Antushevich AY, Polevay LP. Experimental simulation of radio- and chemoradio stomatitis in rats. Bull Exp Biol Med. 2013 Apr;154(6):814-7. PubMed PMID: 23658931. 17: Riya MP, Antu KA, Pal S, Srivastava AK, Sharma S, Raghu KG. Nutraceutical potential of Aerva lanata (L.) Juss. ex Schult ameliorates secondary complications in streptozotocin-induced diabetic rats. Food Funct. 2014 Sep;5(9):2086-95. doi: 10.1039/c4fo00013g. PubMed PMID: 24993661. 18: Chakraborty A, Takade A, Villanueva SY, Yoshida S. Electron microscopic study of the effects of antimicrobial agents on the cellular architecture of Leptospira. J Infect Chemother. 2011 Dec;17(6):872-5. doi: 10.1007/s10156-011-0258-6. Epub 2011 May 20. PubMed PMID: 21597899. 19: Masuda A, Eguchi G. Phenylthiourea enhances Cu cytotoxicity in cell cultures: its mode of action. Cell Struct Funct. 1984 Mar;9(1):25-35. PubMed PMID: 6426807. 20: Antu KA, Riya MP, Mishra A, Sharma S, Srivastava AK, Raghu KG. Symplocos cochinchinensis attenuates streptozotocin-diabetes induced pathophysiological alterations of liver, kidney, pancreas and eye lens in rats. Exp Toxicol Pathol. 2014 Sep;66(7):281-91. doi: 10.1016/j.etp.2014.05.004. Epub 2014 Jun 6. PubMed PMID: 24912748.