Ovuplant | CAS#70235-53-9 | Enzyme Inhibitor

MedKoo Cat#: 598791 | Name: Ovuplant

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ovuplant is tradename for a short-term-release implant containing deslorelin acetate.

Chemical Structure

Ovuplant

CAS#70235-53-9

Theoretical Analysis

MedKoo Cat#: 598791

Name: Ovuplant

CAS#: 70235-53-9

Chemical Formula: C66H86N18O13

Exact Mass: 1338.6622

Molecular Weight: 1339.52

Elemental Analysis: C, 59.18; H, 6.47; N, 18.82; O, 15.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Ovuplant;

IUPAC/Chemical Name

(S)-N-(2-(ethylamino)-2-oxoethyl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide

InChi Key

KPSXIMVWBWSQEG-ITQXDASVSA-N

InChi Code

1S/C66H86N18O13/c1-4-70-56(88)33-74-64(96)54-16-10-24-84(54)65(97)47(15-9-23-71-66(67)68)77-58(90)48(25-36(2)3)78-60(92)50(27-38-30-72-44-13-7-5-11-42(38)44)80-59(91)49(26-37-17-19-41(86)20-18-37)79-63(95)53(34-85)83-61(93)51(28-39-31-73-45-14-8-6-12-43(39)45)81-62(94)52(29-40-32-69-35-75-40)82-57(89)46-21-22-55(87)76-46/h5-8,11-14,17-20,30-32,35-36,46-54,72-73,85-86H,4,9-10,15-16,21-29,33-34H2,1-3H3,(H,69,75)(H,70,88)(H,74,96)(H,76,87)(H,77,90)(H,78,92)(H,79,95)(H,80,91)(H,81,94)(H,82,89)(H,83,93)(H4,67,68,71)/t46-,47-,48-,49-,50+,51-,52-,53-,54-/m0/s1

SMILES Code

NC(NCCC[C@@H](C(N1CCC[C@H]1C(NCC(NCC)=O)=O)=O)NC([C@H](CC(C)C)NC([C@H](NC([C@H](Cc2ccc(O)cc2)NC([C@H](CO)NC([C@H](Cc3c[nH]c4c3cccc4)NC([C@H](Cc5[nH]cnc5)NC([C@H]6NC(CC6)=O)=O)=O)=O)=O)=O)Cc(c[nH]7)c8c7cccc8)=O)=O)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,339.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Finan SA, Lamkin EL, McKinnon AO. Comparative efficacy of BioRelease Deslorelin® injection for induction of ovulation in oestrus mares: a field study. Aust Vet J. 2016 Sep;94(9):338-40. doi: 10.1111/avj.12478. PubMed PMID: 27569838. 2: Wolf T, Meyer H, Kutzler M. Litter size response to oestrous induction with deslorelin (Ovuplant®) in dogs. Reprod Domest Anim. 2012 Dec;47 Suppl 6:387-8. doi: 10.1111/rda.12082. PubMed PMID: 23279545. 3: Fontaine C. Long-term contraception in a small implant: A review of Suprelorin (deslorelin) studies in cats. J Feline Med Surg. 2015 Sep;17(9):766-71. doi: 10.1177/1098612X15594990. Review. PubMed PMID: 26323800; PubMed Central PMCID: PMC5117121. 4: Hemberg E, Lundeheim N, Einarsson S. Successful timing of ovulation using deslorelin (Ovuplant) is labour-saving in mares aimed for single ai with frozen semen. Reprod Domest Anim. 2006 Dec;41(6):535-7. PubMed PMID: 17107513. 5: Farquhar VJ, McCue PM, Carnevale EM, Nett TM, Squires EL. Deslorelin acetate (Ovuplant) therapy in cycling mares: effect of implant removal on FSH secretion and ovarian function. Equine Vet J. 2002 Jul;34(4):417-20. PubMed PMID: 12117117. 6: Padula AM, Macmillan KL. Oestradiol-17beta responsiveness, plasma LH profiles, pituitary LH and FSH concentrations in long-term ovariectomised Holstein cows at 24 h, 48 h and 21 days following treatment with an absorbable GnRH agonist implant. Anim Reprod Sci. 2005 Jan;85(1-2):27-39. PubMed PMID: 15556306. 7: Lucas X. Clinical use of deslorelin (GnRH agonist) in companion animals: a review. Reprod Domest Anim. 2014 Oct;49 Suppl 4:64-71. doi: 10.1111/rda.12388. Review. PubMed PMID: 25277434. 8: Jöchle W. [Control of ovulation in the mare with Ovuplant (short-term release of the GnRH analog deslorelin acetate). Overview of investigations from 1990 to 1994]. Tierarztl Prax. 1995 Aug;23(4):381-93. German. PubMed PMID: 8578571. 9: Borges P, Fontaine E, Maenhoudt C, Payan-Carreira R, Santos N, Leblond E, Fontaine C, Fontbonne A. Fertility in Adult Bitches Previously Treated with a 4.7 mg Subcutaneous Deslorelin Implant. Reprod Domest Anim. 2015 Dec;50(6):965-71. doi: 10.1111/rda.12616. Epub 2015 Oct 8. PubMed PMID: 26447654. 10: Kaya D, Schäfer-Somi S, Kurt B, Kuru M, Kaya S, Kaçar C, Aksoy Ö, Aslan S. Clinical use of deslorelin implants for the long-term contraception in prepubertal bitches: effects on epiphyseal closure, body development, and time to puberty. Theriogenology. 2015 Apr 15;83(7):1147-53. doi: 10.1016/j.theriogenology.2014.12.015. Epub 2014 Dec 20. PubMed PMID: 25619808. 11: McCue PM, Farquhar VJ, Carnevale EM, Squires EL. Removal of deslorelin (Ovuplant) implant 48 h after administration results in normal interovulatory intervals in mares. Theriogenology. 2002 Sep;58(5):865-70. PubMed PMID: 12212887. 12: Murphy K, Wilson DA, Burton M, Slaugh S, Dunning JL, Prather JF. Effectiveness of the GnRH agonist Deslorelin as a tool to decrease levels of circulating testosterone in zebra finches. Gen Comp Endocrinol. 2015 Oct 1;222:150-7. doi: 10.1016/j.ygcen.2015.09.014. Epub 2015 Sep 25. PubMed PMID: 26391838. 13: Novotny R, Vitasek R, Bartoskova A, Cizek P, Prinosilova P, Novakova K. Azoospermia with variable testicular histology after 7 months of treatment with a deslorelin implant in toms. Theriogenology. 2015 Apr 15;83(7):1188-93. doi: 10.1016/j.theriogenology.2014.12.026. Epub 2014 Dec 31. PubMed PMID: 25617987. 14: Zambelli D, Bini C, Küster DG, Molari V, Cunto M. First deliveries after estrus induction using deslorelin and endoscopic transcervical insemination in the queen. Theriogenology. 2015 Sep 15;84(5):773-8. doi: 10.1016/j.theriogenology.2015.05.010. Epub 2015 May 15. PubMed PMID: 26092701. 15: Johnson AE, Freeman EW, Colgin M, McDonough C, Songsasen N. Induction of ovarian activity and ovulation in an induced ovulator, the maned wolf (Chrysocyon brachyurus), using GnRH agonist and recombinant LH. Theriogenology. 2014 Jul 1;82(1):71-9. doi: 10.1016/j.theriogenology.2014.03.009. Epub 2014 Mar 18. PubMed PMID: 24742964. 16: Delaski KM, Gamble KC. EVALUATION OF THYROID HORMONES AND AS INFLUENCED BY TREATMENT WITH DESLORELIN IN PALLAS' CATS (OTOCOLOBUS (FELIS) MANUL). J Zoo Wildl Med. 2015 Dec;46(4):675-81. doi: 10.1638/2013-0298.1. PubMed PMID: 26667522. 17: Goericke-Pesch S, Groeger G, Wehrend A. The effects of a slow release GnRH agonist implant on male rabbits. Anim Reprod Sci. 2015 Jan;152:83-9. doi: 10.1016/j.anireprosci.2014.11.002. Epub 2014 Nov 14. PubMed PMID: 25466212. 18: Schulman ML, Kirberger RM, Tordiffe AS, Marker LL, Schmidt-Küntzel A, Hartman MJ. Ultrasonographic and laparoscopic evaluation of the reproductive tract in older captive female cheetahs (Acinonyx jubatus). Theriogenology. 2015 Dec;84(9):1611-9. doi: 10.1016/j.theriogenology.2015.08.011. Epub 2015 Aug 29. PubMed PMID: 26381758. 19: Lima AG, Costa LC, Alvarenga MA, Martins CB. Does Clinical Treatment with Phenylbutazone and Meloxicam in the Pre-ovulatory Period Influence the Ovulation Rate in Mares? Reprod Domest Anim. 2015 Oct;50(5):771-5. doi: 10.1111/rda.12586. Epub 2015 Aug 17. PubMed PMID: 26280558. 20: Petritz OA, Guzman DS, Hawkins MG, Kass PH, Conley AJ, Paul-Murphy J. COMPARISON OF TWO 4.7-MILLIGRAM TO ONE 9.4-MILLIGRAM DESLORELIN ACETATE IMPLANTS ON EGG PRODUCTION AND PLASMA PROGESTERONE CONCENTRATIONS IN JAPANESE QUAIL (COTURNIX COTURNIX JAPONICA). J Zoo Wildl Med. 2015 Dec;46(4):789-97. doi: 10.1638/2014-0210.1. PubMed PMID: 26667535.