MedKoo Cat#: 558526 | Name: Sulfamethoxypyridazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfamethoxypyridazine is an antibacterial that treats vaginal irritation and severe acute thrush.

Chemical Structure

Sulfamethoxypyridazine
Sulfamethoxypyridazine
CAS#80-35-3

Theoretical Analysis

MedKoo Cat#: 558526

Name: Sulfamethoxypyridazine

CAS#: 80-35-3

Chemical Formula: C11H12N4O3S

Exact Mass: 280.0600

Molecular Weight: 280.30

Elemental Analysis: C, 47.14; H, 4.32; N, 19.99; O, 17.12; S, 11.44

Price and Availability

Size Price Availability Quantity
5g USD 205.00
10g USD 335.00
25g USD 525.00
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Related CAS #
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Synonym
Sulfamethoxypyridazine; Lisulfen; Longin; Medicel; Midicel; Midikel; Myasul
IUPAC/Chemical Name
Benzenesulfonamide, 4-amino-N-(6-methoxy-3-pyridazinyl)-
InChi Key
VLYWMPOKSSWJAL-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)
SMILES Code
O=S(C1=CC=C(N)C=C1)(NC2=NN=C(OC)C=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 280.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rajendiran N, Venkatesh G, Mohandass T. Fabrication of 2D nanosheet through self assembly behavior of sulfamethoxypyridazine inclusion complexes with α- and β-cyclodextrins. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:158-66. doi: 10.1016/j.saa.2013.12.053. Epub 2013 Dec 18. PubMed PMID: 24394532. 2: Khaleel ND, Mahmoud WM, Hadad GM, Abdel-Salam RA, Kümmerer K. Photolysis of sulfamethoxypyridazine in various aqueous media: aerobic biodegradation and identification of photoproducts by LC-UV-MS/MS. J Hazard Mater. 2013 Jan 15;244-245:654-61. doi: 10.1016/j.jhazmat.2012.10.059. Epub 2012 Nov 3. PubMed PMID: 23183348. 3: Garg SK, Uppal RP, Rivière JE. Serum disappearance and urinary excretion of sulfamethoxypyridazine in goats. Rev Elev Med Vet Pays Trop. 1994;47(2):215-8. PubMed PMID: 7863073. 4: White TA, Evans DA. The actylation of sulamethazine and sulfamethoxypyridazine by human subjects. Clin Pharmacol Ther. 1968 Jan-Feb;9(1):80-8. PubMed PMID: 5638098. 5: Tafintseva IIu, Zherdev AV, Eremin SA, Dzantiev BB. [Enzyme immunoassay for determination of sulfamethoxypyridazine in honey]. Prikl Biokhim Mikrobiol. 2010 Mar-Apr;46(2):232-6. Russian. PubMed PMID: 20391769. 6: Sakharov IY, Berlina AN, Zherdev AV, Dzantiev BB. Advantages of soybean peroxidase over horseradish peroxidase as the enzyme label in chemiluminescent enzyme-linked immunosorbent assay of sulfamethoxypyridazine. J Agric Food Chem. 2010 Mar 24;58(6):3284-9. doi: 10.1021/jf904338f. PubMed PMID: 20175541. 7: Abdennebi EH, Bousfiha A, Ben Goumi M, Oukessou M. [Pharmacokinetics and plasma protein binding of sulfamethoxypyridazine in camels (Camelus dromedarius)]. Rev Elev Med Vet Pays Trop. 1994;47(1):97-102. French. PubMed PMID: 7991901. 8: Bartlett MS, Shaw MM, Smith JW, Meshnick SR. Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1998 Apr;42(4):934-5. PubMed PMID: 9559812; PubMed Central PMCID: PMC105571. 9: RYSSING E. [Protracted antibacterial prophylaxis with sulfamethoxypyridazine (Lederkyn) in children with asthma]. Ugeskr Laeger. 1959 Nov 12;121:1768-70. Danish. PubMed PMID: 14440485. 10: Stopp M, Weise C, Mewes S, Bräunlich H. Different inhibitory effects of 2,4-dinitrophenol, iodoacetate, and probenecid on renal excretion of p-aminohippurate, cyclopenthiazide, and sulfamethoxypyridazine in rats. Acta Biol Med Ger. 1976;35(6):787-92. PubMed PMID: 983625. 11: DVORAK K. [SIDE-EFFECTS OF SULFAMETHOXYPYRIDAZINE]. Lek Veda Zahr. 1963 Jul 8;41:135-42. Review. Czech. PubMed PMID: 14069003. 12: PRYLES CV, FINLAND M. N1 acetyl sulfamethoxypyridazine: concentrations in blood and urine during oral administration and comparisons with sulfamethoxypyridazine. Am J Med Sci. 1958 May;235(5):555-61. PubMed PMID: 13533417. 13: Wang Z, Zhang S, Nesterenko IS, Eremin SA, Shen J. Monoclonal antibody-based fluorescence polarization immunoassay for sulfamethoxypyridazine and sulfachloropyridazine. J Agric Food Chem. 2007 Aug 22;55(17):6871-8. Epub 2007 Jul 28. PubMed PMID: 17661485. 14: BIERENT P, DUPOUX R, SCHNEIDER J. [Treatment of trachoma by the injection of suspensions of acetyl-sulfamethoxypyridazine associated with the buccal administration of sulfamethoxypyridazine. Trial with a view to mass treatment. (II)]. Bull Soc Pathol Exot Filiales. 1961 Nov-Dec;54:1284-90. French. PubMed PMID: 13869057. 15: Cosi G, Pacciani M. [Separation and determination of chloramphenicol and sulfamethoxypyridazine in the presence of nitrofurantoin and nicotinamide]. Farmaco Prat. 1966 Jul;21(7):380-6. Italian. PubMed PMID: 4238241. 16: Gach JE, Wilson NJ, Wojnarowska F, Ilchyshyn A. Sulfamethoxypyridazine-responsive pemphigoid nodularis: a report of two cases. J Am Acad Dermatol. 2005 Aug;53(2 Suppl 1):S101-4. PubMed PMID: 16021154. 17: Garg SK, Uppal RP. Bioavailability of sulfamethoxypyridazine following intramuscular or subcutaneous administration in goats. Vet Res. 1997;28(1):101-4. PubMed PMID: 9172837. 18: Bettinetti G, Caira MR, Callegari A, Merli M, Sorrenti M, Tadini C. Structure and solid-state chemistry of anhydrous and hydrated crystal forms of the trimethoprim-sulfamethoxypyridazine 1:1 molecular complex. J Pharm Sci. 2000 Apr;89(4):478-89. PubMed PMID: 10737909. 19: Caramella C, Cocchi GA, Catellani P, Conte U, Colombo P, La Manna A. The effect of some wetting agents on the characteristics of suspensions of sulfamethoxypyridazine and its "N1-acetyl derivative. Boll Chim Farm. 1976 Sep;115(9):658-66. PubMed PMID: 1016621. 20: LINDSAY DG, PRLINA I, BISCHOFF AJ, BECKER SW Sr. Cutaneous reactions due to sulfamethoxypyridazine. AMA Arch Derm. 1958 Sep;78(3):299-303. PubMed PMID: 13570680.