LG 50046 | CAS#1703-32-8 | bioactive chemical

MedKoo Cat#: 598767 | Name: LG 50046

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG 50046 is a bioactive chemical.

Chemical Structure

LG 50046

CAS#1703-32-8

Theoretical Analysis

MedKoo Cat#: 598767

Name: LG 50046

CAS#: 1703-32-8

Chemical Formula: C17H23NO6

Exact Mass: 337.1525

Molecular Weight: 337.37

Elemental Analysis: C, 60.52; H, 6.87; N, 4.15; O, 28.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LG 50046; LG-50046; LG50046; LG 50,046; LG-50,046; LG50,046;

IUPAC/Chemical Name

2,6-dimethoxy-4-(piperidine-1-carbonyl)phenyl ethyl carbonate

InChi Key

BRKLZMLKIKEGJW-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H23NO6/c1-4-23-17(20)24-15-13(21-2)10-12(11-14(15)22-3)16(19)18-8-6-5-7-9-18/h10-11H,4-9H2,1-3H3

SMILES Code

O=C(N1CCCCC1)C2=CC(OC)=C(OC(OCC)=O)C(OC)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

LG 50046 is a bioactive chemical.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 337.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

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PubMed PMID: 15278626. 5: Komatsu H, Takehana Y, Kikuchi S, Kojima M, Hamano S, Kusama H, Okegawa T, Ikeda S. Effect of a thromboxane A2 synthetase inhibitor (OKY-046.HCl) on airway hyperresponsiveness in guinea pigs. Eur J Pharmacol. 1990 Aug 2;184(1):87-95. PubMed PMID: 2170151. 6: Hora K, Oguchi H, Furukawa T, Hora K, Tokunaga S. Effects of a selective thromboxane synthetase inhibitor OKY-046 on experimental diabetic nephropathy. Nephron. 1990;56(3):297-305. PubMed PMID: 2077412. 7: Nagai H, Yakuo I, Togawa M, Arimura A, Matsuura N, Koda A, Hamano S, Ujiie A, Nakazawa M. Effect of OKY-046, a new thromboxane A2 synthetase inhibitor, on experimental asthma in guinea pigs. Prostaglandins Leukot Med. 1987 Dec;30(2-3):111-21. PubMed PMID: 2447593. 8: Hiraku S, Taniguchi K, Wakitani K, Omawari N, Kira H, Miyamoto T, Okegawa T, Kawasaki A, Ujiie A. Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn J Pharmacol. 1986 Jul;41(3):393-401. PubMed PMID: 3093741. 9: Ghodgaonkar RB, Dubin NH. Effect of OKY-046, a selective thromboxane inhibitor, on prostaglandin production and function of pregnant rat uteri and platelets. Prostaglandins Leukot Med. 1987 Jan;26(1):33-46. PubMed PMID: 3468521. 10: Fujimura M, Sasaki F, Nakatsumi Y, Takahashi Y, Hifumi S, Taga K, Mifune J, Tanaka T, Matsuda T. Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax. 1986 Dec;41(12):955-9. PubMed PMID: 3590057; PubMed Central PMCID: PMC460553. 11: Morio H, Hirai A, Terano T, Tamura Y, Yoshida S. Effect of the infusion of OKY-046, a thromboxane A2 synthase inhibitor, on urinary metabolites of prostacyclin and thromboxane A2 in healthy human subjects. Thromb Haemost. 1993 Mar 1;69(3):276-81. PubMed PMID: 8470052. 12: Tsai JJ, Tsai CF, Wang SR, Han SH. The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs. Asian Pac J Allergy Immunol. 1995 Dec;13(2):87-93. PubMed PMID: 8703249. 13: Nagai H, Yakuo I, Nakatomi I, Inagaki N, Koda A. The role of thromboxane A2 (TxA2) in allergic cutaneous reactions and the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) phenyl]-2-propenoic acid hydrochloride (OKY-046), a TxA2 synthetase inhibitor. Prostaglandins Leukot Essent Fatty Acids. 1989 Mar;35(3):125-30. PubMed PMID: 2710796. 14: Uyama O, Nagatsuka K, Nakabayashi S, Isaka Y, Yoneda S, Kimura K, Abe H. The effect of a thromboxane synthetase inhibitor, OKY-046, on urinary excretion of immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in patients with ischemic cerebrovascular disease. Stroke. 1985 Mar-Apr;16(2):241-4. PubMed PMID: 3883580. 15: Takahashi T. The effects of thromboxane A2 synthetase inhibitor (OKY-046) on complete hepatic ischemia in rats with obstructive jaundice. Surg Today. 1996;26(1):15-20. PubMed PMID: 8680115. 16: Takehana Y, Kikuchi S, Hara K, Hamano S, Komatsu H, Ujiie A, Okegawa T, Ikeda S. [Anti-allergic effects of (E)-3-[p-(1H-imidazol-1-lylmethyl) phenyl]-2-propenoic acid (OKY-046), a specific thromboxane (TX) A2 synthetase inhibitor: effects on type I allergic reactions]. Nihon Yakurigaku Zasshi. 1990 Mar;95(3):121-30. Japanese. PubMed PMID: 1693906. 17: Kobayashi T, Esato K, Morita N, Noshima NS. Effects of thromboxane A2 synthesis inhibitor (OKY-046) on total liver ischemia in rats. Int Surg. 1996 Apr-Jun;81(2):115-8. PubMed PMID: 8912073. 18: Nagai H, Aoki M, Shimazawa T, Yakuo I, Koda A, Kasahara M. Effect of OKY-046 and ONO-3708 on liver injury in mice. Jpn J Pharmacol. 1989 Oct;51(2):191-7. PubMed PMID: 2512404. 19: Garvin PJ, Niehoff ML, Robinson SM. Effects of tetrodotoxin and OKY-046 in renal ischemia reperfusion. J Surg Res. 1999 Aug;85(2):273-8. PubMed PMID: 10423329. 20: Ishihara Y, Uchida Y, Kitamura S. Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs. Prostaglandins Leukot Med. 1986 Feb;21(2):197-206. PubMed PMID: 3457388.