MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 461440 | Name: Oxadiargyl
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxadiargyl is a protoporphyrinogen oxidase inhibitor and is used as a herbicide in China. Oxadiargyl affects the germination and seedling growth of rice, causing damage to the plant and reducing rice yield.

Chemical Structure

Oxadiargyl
Oxadiargyl
CAS#39807-15-3

Theoretical Analysis

MedKoo Cat#: 461440

Name: Oxadiargyl

CAS#: 39807-15-3

Chemical Formula: C15H14Cl2N2O3

Exact Mass: 340.0381

Molecular Weight: 341.19

Elemental Analysis: Chemical Formula: C15H14Cl2N2O3 Exact Mass: 340.0381 Molecular Weight: 341.1880 Elemental Analysis: C, 52.81; H, 4.14; Cl, 20.78; N, 8.21; O, 14.07

Price and Availability

Size Price Availability Quantity
100mg USD 350.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Oxadiargyl; Topstar; RP 020630; RP-020630; RP020630;
IUPAC/Chemical Name
5-(tert-butyl)-3-(2,4-dichloro-5-(prop-2-yn-1-yloxy)phenyl)-1,3,4-oxadiazol-2(3H)-one
InChi Key
DVOODWOZJVJKQR-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14Cl2N2O3/c1-5-6-21-12-8-11(9(16)7-10(12)17)19-14(20)22-13(18-19)15(2,3)4/h1,7-8H,6H2,2-4H3
SMILES Code
O=C1OC(C(C)(C)C)=NN1C2=CC(OCC#C)=C(Cl)C=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Oxadiargyl is a protoporphyrinogen oxidase inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 341.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Rees KC, Dou Z, Whitehead DC. Oxadiazon Derivatives Elicit Potent Intracellular Growth Inhibition against Toxoplasma gondii by Disrupting Heme Biosynthesis. ACS Infect Dis. 2022 May 13;8(5):911-917. doi: 10.1021/acsinfecdis.2c00020. Epub 2022 Apr 1. PMID: 35363476; PMCID: PMC9106912. 2: Budak TB, Ayyıldız MF, Chormey DS, Bakırdere S. Combination of vortex assisted binary solvent microextraction and QuEChERS for the determination of prothiofos, oxadiargyl, and gamma-cyhalothrin in water and pineapple samples by gas chromatography mass spectrometry. Environ Monit Assess. 2020 Apr 8;192(5):273. doi: 10.1007/s10661-020-8209-2. PMID: 32266493. 3: Deng X, Zhou Y, Zheng W, Bai L, Zhou X. Dissipation Dynamic and Final Residues of Oxadiargyl in Paddy Fields Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry Coupled with Modified QuEChERS Method. Int J Environ Res Public Health. 2018 Aug 7;15(8):1680. doi: 10.3390/ijerph15081680. PMID: 30087273; PMCID: PMC6121607. 4: Ahmed A, Shamsi A, Bano B. Oxadiargyl induced conformational transition of cystatin isolated from yellow mustard seeds: Biophysical and biochemical approach. Int J Biol Macromol. 2017 May;98:802-809. doi: 10.1016/j.ijbiomac.2017.02.055. Epub 2017 Feb 16. PMID: 28214581. 5: Singh V, Jat ML, Ganie ZA, Chauhan BS, Gupta RK. Herbicide options for effective weed management in dry direct-seeded rice under scented rice-wheat rotation of western Indo-Gangetic Plains. Crop Prot. 2016 Mar;81:168-176. doi: 10.1016/j.cropro.2015.12.021. PMID: 26941471; PMCID: PMC4767026. 6: Kang G, Kim J, Park H, Kim TH. Crystal structure of oxadiarg-yl. Acta Crystallogr E Crystallogr Commun. 2015 Jun 20;71(Pt 7):o494. doi: 10.1107/S2056989015011524. PMID: 26279926; PMCID: PMC4518994. 7: Sanyal N, Alam S, Pradhan S, Banerjee K, Chowdhury A, Aktar MW. Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition. Environ Monit Assess. 2015 Jul;187(7):433. doi: 10.1007/s10661-015-4345-5. Epub 2015 Jun 16. PMID: 26077021. 8: Es-Haghi A, Baghernejad M, Bagheri H. Novel unbreakable solid-phase microextraction fibers on stainless steel wire and application for the determination of oxadiargyl in environmental and agricultural samples in combination with gas chromatography-mass spectrometry. Talanta. 2014 Oct;128:231-6. doi: 10.1016/j.talanta.2014.04.088. Epub 2014 May 13. PMID: 25059153. 9: Ahmed S, Chauhan BS. Performance of different herbicides in dry-seeded rice in Bangladesh. ScientificWorldJournal. 2014 Feb 6;2014:729418. doi: 10.1155/2014/729418. PMID: 24688423; PMCID: PMC3933028. 10: Benfeito S, Rodrigues T, Garrido J, Borges F, Garrido EM. Host-guest interaction between herbicide oxadiargyl and hydroxypropyl-β-cyclodextrin. ScientificWorldJournal. 2013 Nov 25;2013:825206. doi: 10.1155/2013/825206. PMID: 24396310; PMCID: PMC3874296. 11: Mahmoudi M, Rahnemaie R, Es-haghi A, Malakouti MJ. Kinetics of degradation and adsorption-desorption isotherms of thiobencarb and oxadiargyl in calcareous paddy fields. Chemosphere. 2013 May;91(7):1009-17. doi: 10.1016/j.chemosphere.2013.01.077. Epub 2013 Feb 22. PMID: 23461836. 12: Jiang LL, Tan Y, Zhu XL, Wang ZF, Zuo Y, Chen Q, Xi Z, Yang GF. Design, synthesis, and 3D-QSAR analysis of novel 1,3,4-oxadiazol-2(3H)-ones as protoporphyrinogen oxidase inhibitors. J Agric Food Chem. 2010 Mar 10;58(5):2643-51. doi: 10.1021/jf9026298. PMID: 19954223. 13: Shi C, Gui W, Chen J, Zhu G. Determination of oxadiargyl residues in environmental samples and rice samples. Bull Environ Contam Toxicol. 2010 Feb;84(2):236-9. doi: 10.1007/s00128-009-9881-7. Epub 2009 Sep 27. PMID: 19784803. 14: Ma J, Wang S, Wang P, Ma L, Chen X, Xu R. Toxicity assessment of 40 herbicides to the green alga Raphidocelis subcapitata. Ecotoxicol Environ Saf. 2006 Mar;63(3):456-62. doi: 10.1016/j.ecoenv.2004.12.001. PMID: 16406601. 15: Dayan FE, Meazza G, Bettarini F, Signorini E, Piccardi P, Romagni JG, Duke SO. Synthesis, herbicidal activity, and mode of action of IR 5790. J Agric Food Chem. 2001 May;49(5):2302-7. doi: 10.1021/jf001393o. PMID: 11368593.