Lew 10 | CAS#123580-53-0 | synthetic flavonoid

MedKoo Cat#: 598750 | Name: Lew 10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lew 10 is a synthetic flavonoid and derivative of diosmin.

Chemical Structure

Lew 10

CAS#123580-53-0

Theoretical Analysis

MedKoo Cat#: 598750

Name: Lew 10

CAS#: 123580-53-0

Chemical Formula: C38H44N2O15

Exact Mass: 768.2742

Molecular Weight: 768.77

Elemental Analysis: C, 59.37; H, 5.77; N, 3.64; O, 31.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Lew 10; Lew-10; Lew10;

IUPAC/Chemical Name

5-hydroxy-2-(4-methoxy-3-(2-oxo-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethoxy)phenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

InChi Key

CNMUTGICIHOIEX-IHQQTPIISA-N

InChi Code

InChI=1S/C38H44N2O15/c1-48-25-7-5-20(27-16-24(43)32-23(42)14-22(15-29(32)54-27)53-38-35(47)34(46)33(45)30(18-41)55-38)13-28(25)52-19-31(44)40-11-9-39(10-12-40)17-21-6-8-26(49-2)37(51-4)36(21)50-3/h5-8,13-16,30,33-35,38,41-42,45-47H,9-12,17-19H2,1-4H3/t30-,33-,34+,35-,38-/m1/s1

SMILES Code

COC1=CC=C(CN2CCN(C(COC3=CC(C4=CC(C5=C(O)C=C(O[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)C=C5O4)=O)=CC=C3OC)=O)CC2)C(OC)=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Lew 10 is a synthetic flavonoid and derivative of diosmin.

In vitro activity:

Two optical techniques, Quasi-elastic Light Scattering (QLS) and Fourier Transform Infrared Spectroscopy (FT-IR) were used. The results show that in the presence of LEW-10, the phase transition of the bilayers is lowered and that the elastic modulus is decreased. The FT-IR results indicate interactions in the aqueous interface regions of the bilayers. Reference: Chem Phys Lipids. 1992 Dec;63(3):169-77. https://pubmed.ncbi.nlm.nih.gov/1493613/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 768.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Azize B, Cao A, Hantz-Brachet E, Perret G, Lewin G, Taillandier E. Thermal behavior and elastic properties of phospholipid bilayers under the effect of a synthetic flavonoid derivative, LEW-10. Chem Phys Lipids. 1992 Dec;63(3):169-77. doi: 10.1016/0009-3084(92)90033-l. PMID: 1493613.

In vitro protocol:

In vivo protocol:

TBD

1: Azize B, Cao A, Hantz-Brachet E, Perret G, Lewin G, Taillandier E. Thermal behavior and elastic properties of phospholipid bilayers under the effect of a synthetic flavonoid derivative, LEW-10. Chem Phys Lipids. 1992 Dec;63(3):169-77. PubMed PMID: 1493613.