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MedKoo Cat#: 584493 | Name: Flonicamid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flonicamid is a pyridinecarboxamide insecticide. Flonicamid inhibits aphid (M. persicae) salivation and sap ingestion during feeding on Japanese radish leaves. It induces toxicity in the aphid species A. gossypii, R. padi, S. graminum, and L. erysimi and rats. Formulations containing flonicamid have been used for the control of pest insects in agriculture.

Chemical Structure

Flonicamid
Flonicamid
CAS#158062-67-0

Theoretical Analysis

MedKoo Cat#: 584493

Name: Flonicamid

CAS#: 158062-67-0

Chemical Formula: C9H6F3N3O

Exact Mass: 229.0463

Molecular Weight: 229.16

Elemental Analysis: C, 47.17; H, 2.64; F, 24.87; N, 18.34; O, 6.98

Price and Availability

Size Price Availability Quantity
250mg USD 450.00 2 Weeks
1g USD 950.00 2 Weeks
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Related CAS #
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Synonym
Flonicamid;
IUPAC/Chemical Name
N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide
InChi Key
RLQJEEJISHYWON-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H6F3N3O/c10-9(11,12)7-1-3-14-5-6(7)8(16)15-4-2-13/h1,3,5H,4H2,(H,15,16)
SMILES Code
O=C(C1=C(C(F)(F)F)C=CN=C1)NCC#N
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 229.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Spalthoff C, Salgado VL, Theis M, Geurten BRH, Göpfert MC. Flonicamid metabolite 4-trifluoromethylnicotinamide is a chordotonal organ modulator insecticide†. Pest Manag Sci. 2022 Nov;78(11):4802-4808. doi: 10.1002/ps.7101. Epub 2022 Aug 15. PMID: 35904889. 2: Yang W, Fan Z, Jiang H, Zhao Y, Guo L, Dai Y. Biotransformation of flonicamid and sulfoxaflor by multifunctional bacterium Ensifer meliloti CGMCC 7333. J Environ Sci Health B. 2021;56(2):122-131. doi: 10.1080/03601234.2020.1852854. Epub 2020 Dec 6. PMID: 33283619. 3: Meng X, Wu Z, Yang X, Qian K, Zhang N, Jiang H, Yin X, Guan D, Zheng Y, Wang J. Flonicamid and knockdown of inward rectifier potassium channel gene CsKir2B adversely affect the feeding and development of Chilo suppressalis. Pest Manag Sci. 2021 Apr;77(4):2045-2053. doi: 10.1002/ps.6232. Epub 2021 Jan 12. PMID: 33342029. 4: Yang WL, Dai ZL, Cheng X, Fan ZX, Jiang HY, Dai YJ. Biotransformation of insecticide flonicamid by Aminobacter sp. CGMCC 1.17253 via nitrile hydratase catalysed hydration pathway. J Appl Microbiol. 2021 May;130(5):1571-1581. doi: 10.1111/jam.14880. Epub 2020 Oct 22. PMID: 33030814. 5: Abbas N, Abubakar M, Hassan MW, Shad SA, Hafez AM. Risk Assessment of Flonicamid Resistance in Musca domestica (Diptera: Muscidae): Resistance Monitoring, Inheritance, and Cross-Resistance Potential. J Med Entomol. 2021 Jul 16;58(4):1779-1787. doi: 10.1093/jme/tjab036. PMID: 33758935. 6: Wang Y, Xue J, Jin H, Ma S. Dissipation of Flonicamid in Honeysuckle and Its Transfer during Brewing Process. Chem Pharm Bull (Tokyo). 2017 May 1;65(5):492-497. doi: 10.1248/cpb.c16-01015. Epub 2017 Mar 18. PMID: 28320974. 7: Zhang T, Xu Y, Zhou X, Liang X, Bai Y, Sun F, Zhang W, Wang N, Pang X, Li Y. Dissipation Kinetics and Safety Evaluation of Flonicamid in Four Various Types of Crops. Molecules. 2022 Dec 6;27(23):8615. doi: 10.3390/molecules27238615. PMID: 36500708; PMCID: PMC9738400. 8: Li H, Zhong Q, Wang X, Luo F, Zhou L, Sun H, Yang M, Lou Z, Chen Z, Zhang X. The degradation and metabolism of chlorfluazuron and flonicamid in tea: A risk assessment from tea garden to cup. Sci Total Environ. 2021 Feb 1;754:142070. doi: 10.1016/j.scitotenv.2020.142070. Epub 2020 Aug 29. PMID: 32920390. 9: Wang S, Jin F, Cao X, Shao Y, Wang J, She Y, Qi Y, Zhang C, Li H, Jin M, Wang J, Shao H, Zheng L. Residue behaviors and risk assessment of flonicamid and its metabolites in the cabbage field ecosystem. Ecotoxicol Environ Saf. 2018 Oct;161:420-429. doi: 10.1016/j.ecoenv.2018.05.074. Epub 2018 Jun 13. PMID: 29908453. 10: Ren M, Niu J, Hu B, Wei Q, Zheng C, Tian X, Gao C, He B, Dong K, Su J. Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests. Insect Biochem Mol Biol. 2018 Aug;99:17-26. doi: 10.1016/j.ibmb.2018.05.007. Epub 2018 May 26. PMID: 29842935. 11: Morita M, Ueda T, Yoneda T, Koyanagi T, Haga T. Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding. Pest Manag Sci. 2007 Oct;63(10):969-73. doi: 10.1002/ps.1423. PMID: 17659536. 12: Gul H, Ul Haq I, Ullah F, Khan S, Yaseen A, Shah SH, Tariq K, Güncan A, Desneux N, Liu X. Impact of sublethal concentrations of flonicamid on key demographic parameters and feeding behavior of Schizaphis graminum. Ecotoxicology. 2023 Aug;32(6):756-767. doi: 10.1007/s10646-023-02682-3. Epub 2023 Jul 18. PMID: 37462788. 13: Yang WL, Guo LL, Dai ZL, Qin RC, Zhao YX, Dai YJ. Biodegradation of the Insecticide Flonicamid by Alcaligenes faecalis CGMCC 17553 via Hydrolysis and Hydration Pathways Mediated by Nitrilase. J Agric Food Chem. 2019 Sep 11;67(36):10032-10041. doi: 10.1021/acs.jafc.9b04245. Epub 2019 Aug 28. PMID: 31419121. 14: Jiang H, Tian Y, Chen J, Zhang Z, Xu H. Enhanced uptake of drip-applied flonicamid by arbuscular mycorrhizal fungi and improved control of cotton aphid. Pest Manag Sci. 2020 Dec;76(12):4222-4230. doi: 10.1002/ps.5979. Epub 2020 Aug 14. PMID: 32594648. 15: EFSA (European Food Safety Authority); Anastassiadou M, Bernasconi G, Brancato A, Carrasco Cabrera L, Greco L, Jarrah S, Kazocina A, Leuschner R, Magrans JO, Miron I, Nave S, Pedersen R, Reich H, Rojas A, Sacchi A, Santos M, Stanek A, Theobald A, Vagenende B, Verani A. Setting of import tolerances for flonicamid in various crops and products of animal origin. EFSA J. 2020 Jun 23;18(6):e06136. doi: 10.2903/j.efsa.2020.6136. PMID: 32874321; PMCID: PMC7448087. 16: Yang Y, Liu X, Zhang Q, Chen Y, Zhang S, Lu P, Hu D. Dissipation, Processing, Leaching, and Safety Evaluation of Flonicamid and Its Metabolites in Tea. J AOAC Int. 2020 Nov 1;103(6):1441-1450. doi: 10.1093/jaoacint/qsaa052. PMID: 33247740. 17: Roditakis E, Fytrou N, Staurakaki M, Vontas J, Tsagkarakou A. Activity of flonicamid on the sweet potato whitely Bemisia tabaci (Homoptera: Aleyrodidae) and its natural enemies. Pest Manag Sci. 2014 Oct;70(10):1460-7. doi: 10.1002/ps.3723. Epub 2014 Feb 19. PMID: 24408346. 18: Kumar Karedla A, Surya Raj R, Krishnamoorthy SV, Suganthi A, Bhuvaneswari K, Karthikeyan S, Geetha P, Senthilkumar M, Jeyarajan Nelson S. Validation, dissipation kinetics and monitoring of flonicamid and dinotefuran residues in paddy grain, straw, its processed produces and bran oil using LC-MS/MS. Food Chem. 2024 Mar 1;435:137589. doi: 10.1016/j.foodchem.2023.137589. Epub 2023 Sep 29. PMID: 37804733. 19: Li J, Wang Y, Xue J, Wang P, Shi S. Dietary Exposure Risk Assessment of Flonicamid and Its Effect on Constituents after Application in Lonicerae Japonicae Flos. Chem Pharm Bull (Tokyo). 2018 Jun 1;66(6):608-611. doi: 10.1248/cpb.c17-00985. Epub 2018 Mar 14. PMID: 29540625. 20: Xu F, Du G, Xu D, Chen L, Zha X, Guo Z. Residual behavior and dietary intake risk assessment of flonicamid, dinotefuran and its metabolites on peach trees. J Sci Food Agric. 2021 Nov;101(14):5842-5850. doi: 10.1002/jsfa.11236. Epub 2021 Apr 14. PMID: 33788960.