Synonym
Ropizine; Ropizina; SC 13504; SC-13504; SC13504;
IUPAC/Chemical Name
(E)-N-(4-benzhydrylpiperazin-1-yl)-1-(6-methylpyridin-2-yl)methanimine
InChi Key
UZDGLRYWBSKLQY-NCELDCMTSA-N
InChi Code
InChI=1S/C24H26N4/c1-20-9-8-14-23(26-20)19-25-28-17-15-27(16-18-28)24(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-14,19,24H,15-18H2,1H3/b25-19+
SMILES Code
CC1=CC=CC(/C=N/N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
370.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Canoll PD, Smith PR, Musacchio JM. Ropizine concurrently enhances and inhibits [3H]dextromethorphan binding to different structures of the guinea pig brain: autoradiographic evidence for multiple binding sites. Life Sci. 1990;46(19):PL9-16. PubMed PMID: 2345483.
2: Edmonds HL Jr, Bellin SI, Chen FC, Hegreberg GA. Anticonvulsant properties of ropizine in epileptic and nonepileptic beagle dogs. Epilepsia. 1978 Apr;19(2):139-46. PubMed PMID: 639771.
3: Klein M, Musacchio JM. Computer-assisted analysis of dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine. Life Sci. 1990;47(18):1625-34. PubMed PMID: 2250576.
4: Klein M, Musacchio JM. High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine. J Pharmacol Exp Ther. 1992 Mar;260(3):990-9. PubMed PMID: 1312173.
5: Canoll PD, Smith PR, Gottesman S, Musacchio JM. Autoradiographic localization of [3H]dextromethorphan in guinea pig brain: allosteric enhancement by ropizine. J Neurosci Res. 1989 Oct;24(2):311-28. PubMed PMID: 2585552.
6: Musacchio JM, Klein M, Santiago LJ. High affinity dextromethorphan binding sites in guinea pig brain: further characterization and allosteric interactions. J Pharmacol Exp Ther. 1988 Nov;247(2):424-31. PubMed PMID: 3183944.
7: Edmonds HL Jr, Stark LG, Stark DM, McCormack CR, Sylvester DM, Bellin SI. The anticonvulsant activity of ropizine in the rat. J Pharmacol Exp Ther. 1979 Feb;208(2):236-42. PubMed PMID: 762654.
8: Musacchio JM, Klein M, Paturzo JJ. Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine. Mol Pharmacol. 1989 Jan;35(1):1-5. PubMed PMID: 2536463.
9: Canoll PD, Smith PR, Gottesman S, Musacchio JM. Autoradiographic localization of [3H]dextromethorphan (DM) in guinea pig brain: allosteric enhancement by ropizine. Prog Clin Biol Res. 1990;328:171-4. PubMed PMID: 2304943.
10: Novack GD, Stark LG, Peterson SL. Anticonvulsant effects of benzhydryl piperazines on maximal electroshock seizures in rats. J Pharmacol Exp Ther. 1979 Mar;208(3):480-4. PubMed PMID: 34712.
11: Thurgur C, Church J. The anticonvulsant actions of sigma receptor ligands in the Mg2+-free model of epileptiform activity in rat hippocampal slices. Br J Pharmacol. 1998 Jul;124(5):917-29. PubMed PMID: 9692777; PubMed Central PMCID: PMC1565460.
12: Musacchio JM, Klein M. Dextromethorphan binding sites in the guinea pig brain. Cell Mol Neurobiol. 1988 Jun;8(2):149-56. Review. PubMed PMID: 3044591.
