Levitide | CAS#114281-19-5 | neurohormone-like peptide

MedKoo Cat#: 598714 | Name: Levitide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Levitide is a neurohormone-like peptide from the skin of Xenopus laevis.

Chemical Structure

Levitide

CAS#114281-19-5

Theoretical Analysis

MedKoo Cat#: 598714

Name: Levitide

CAS#: 114281-19-5

Chemical Formula: C66H119N21O19S

Exact Mass: 1541.8712

Molecular Weight: 1542.86

Elemental Analysis: C, 51.38; H, 7.77; N, 19.06; O, 19.70; S, 2.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Levitide; Glu-gly-met-ile-gly-thr-leu-thr-ser-lys-arg-ile-lys-gln-NH(2);

IUPAC/Chemical Name

(S)-2-((6S,9S,15S,18S,21S,24S,27S,30S,33S,36S)-27,36-bis(4-aminobutyl)-9,33-di((S)-sec-butyl)-30-(3-guanidinopropyl)-15,21-bis((R)-1-hydroxyethyl)-24-(hydroxymethyl)-18-isobutyl-6-(2-(methylthio)ethyl)-1,4,7,10,13,16,19,22,25,28,31,34-dodecaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20,23,26,29,32,35-dodecaazaheptatriacontan-37-amido)pentanediamide

InChi Key

LDCPZBREJGHLQM-MUFHBRNXSA-N

InChi Code

InChI=1S/C66H119N21O19S/c1-10-34(5)50(85-59(100)43(24-28-107-9)77-48(93)30-74-55(96)42-21-23-47(92)76-42)62(103)75-31-49(94)84-52(36(7)89)64(105)82-44(29-33(3)4)60(101)87-53(37(8)90)65(106)83-45(32-88)61(102)80-39(17-12-14-25-67)57(98)79-41(19-16-27-73-66(71)72)58(99)86-51(35(6)11-2)63(104)81-40(18-13-15-26-68)56(97)78-38(54(70)95)20-22-46(69)91/h33-45,50-53,88-90H,10-32,67-68H2,1-9H3,(H2,69,91)(H2,70,95)(H,74,96)(H,75,103)(H,76,92)(H,77,93)(H,78,97)(H,79,98)(H,80,102)(H,81,104)(H,82,105)(H,83,106)(H,84,94)(H,85,100)(H,86,99)(H,87,101)(H4,71,72,73)/t34-,35-,36+,37+,38-,39-,40-,41-,42-,43-,44-,45-,50-,51-,52-,53-/m0/s1

SMILES Code

CC[C@@H]([C@H](NC([C@@H](NC(CNC([C@@H]1CCC(N1)=O)=O)=O)CCSC)=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCC(N)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)[C@H](O)C)=O)CC(C)C)=O)[C@H](O)C)=O)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,542.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M. Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis. FEBS J. 2015 Jan;282(1):102-13. doi: 10.1111/febs.13107. Epub 2014 Oct 30. PubMed PMID: 25312021. 2: Poulter L, Terry AS, Williams DH, Giovannini MG, Moore CH, Gibson BW. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83. PubMed PMID: 2830279. 3: Kuchler K, Kreil G, Sures I. The genes for the frog skin peptides GLa, xenopsin, levitide and caerulein contain a homologous export exon encoding a signal sequence and part of an amphiphilic peptide. Eur J Biochem. 1989 Feb 1;179(2):281-5. PubMed PMID: 2465151. 4: Carraway RE, Mitra SP. Isolation and sequence of canine xenopsin and an extended fragment from its precursor. Peptides. 1990 Jul-Aug;11(4):747-52. PubMed PMID: 2235681. 5: Pierre TN, Seon AA, Amiche M, Nicolas P. Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors. Eur J Biochem. 2000 Jan;267(2):370-8. PubMed PMID: 10632707. 6: James S, Gibbs BF, Toney K, Bennett HP. Purification of antimicrobial peptides from an extract of the skin of Xenopus laevis using heparin-affinity HPLC: characterization by ion-spray mass spectrometry. Anal Biochem. 1994 Feb 15;217(1):84-90. PubMed PMID: 8203742. 7: Langerveld AJ, Celestine R, Zaya R, Mihalko D, Ide CF. Chronic exposure to high levels of atrazine alters expression of genes that regulate immune and growth-related functions in developing Xenopus laevis tadpoles. Environ Res. 2009 May;109(4):379-89. doi: 10.1016/j.envres.2009.01.006. Epub 2009 Mar 9. PubMed PMID: 19272595. 8: Kuks PF, Créminon C, Leseney AM, Bourdais J, Morel A, Cohen P. Xenopus laevis skin Arg-Xaa-Val-Arg-Gly-endoprotease. A highly specific protease cleaving after a single arginine of a consensus sequence of peptide hormone precursors. J Biol Chem. 1989 Sep 5;264(25):14609-12. PubMed PMID: 2670921.