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MedKoo Cat#: 598707 | Name: Levdobutamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Levdobutamine is a bioactive chemical.

Chemical Structure

Levdobutamine
CAS#61661-06-1

Theoretical Analysis

MedKoo Cat#: 598707

Name: Levdobutamine

CAS#: 61661-06-1

Chemical Formula: C18H23NO3

Exact Mass: 301.1678

Molecular Weight: 301.38

Elemental Analysis: C, 71.73; H, 7.69; N, 4.65; O, 15.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Levdobutamine;
IUPAC/Chemical Name
(S)-4-(2-((4-(4-hydroxyphenyl)butan-2-yl)amino)ethyl)benzene-1,2-diol
InChi Key
JRWZLRBJNMZMFE-ZDUSSCGKSA-N
InChi Code
InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3/t13-/m0/s1
SMILES Code
Oc1ccc(CC[C@H](C)NCCc2cc(O)c(O)cc2)cc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 301.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Epub 2005 Jul 22. PubMed PMID: 16040714. 8: Salimian S, Thibault B, Finnerty V, Grégoire J, Harel F. The effects of dobutamine stress on cardiac mechanical synchrony determined by phase analysis of gated SPECT myocardial perfusion imaging in a canine model. J Nucl Cardiol. 2014 Apr;21(2):375-83. doi: 10.1007/s12350-013-9847-3. Epub 2014 Jan 9. PubMed PMID: 24402711. 9: Egstrup M, Gustafsson I, Andersen MJ, Kistorp CN, Schou M, Tuxen CD, Møller JE. Haemodynamic response during low-dose dobutamine infusion in patients with chronic systolic heart failure: comparison of echocardiographic and invasive measurements. Eur Heart J Cardiovasc Imaging. 2013 Jul;14(7):659-67. doi: 10.1093/ehjci/jes234. Epub 2012 Nov 6. PubMed PMID: 23136446. 10: Gandham R, Syamasundar A, Ravulapalli H, Karthekeyan RB, Vakamudi M, Kodalli R, Nandipati S. A comparison of hemodynamic effects of levosimendan and dobutamine in patients undergoing mitral valve repair / replacement for severe mitral stenosis. Ann Card Anaesth. 2013 Jan-Mar;16(1):11-5. doi: 10.4103/0971-9784.105363. PubMed PMID: 23287080. 11: Harel F, Finnerty V, Grégoire J, Salimian S, Thibault B. Effects of dobutamine stress on cardiac contraction synchronism in a canine model. Physiol Meas. 2013 Oct;34(10):1387-97. doi: 10.1088/0967-3334/34/10/1387. Epub 2013 Sep 25. PubMed PMID: 24065617. 12: Sun CZ, Shen H, He XW, Bao L, Song Y, Zhang Z, Qin HD. Effect of dobutamine on lung aquaporin 5 in endotoxine shock-induced acute lung injury rabbit. J Thorac Dis. 2015 Aug;7(8):1467-77. doi: 10.3978/j.issn.2072-1439.2015.08.22. PubMed PMID: 26380773; PubMed Central PMCID: PMC4561258. 13: Lagudis S, Yamada AT, Vieira ML, Medeiros CC, Mansur AJ, Lage SG. The effect of dobutamine without and with L-arginine on arterial compliance in heart failure patients. Echocardiography. 2009 Sep;26(8):934-42. doi: 10.1111/j.1540-8175.2009.00908.x. PubMed PMID: 19968681. 14: Mehrotra P, Labib SB, Schick EC. Differential effects of dobutamine versus treadmill exercise on left ventricular volume and wall stress. J Am Soc Echocardiogr. 2012 Aug;25(8):911-8. doi: 10.1016/j.echo.2012.05.002. Epub 2012 Jun 2. PubMed PMID: 22658422. 15: Huang Y, Kwok KH, Chan NW, Lau CW, Chen ZY. Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery. Clin Exp Pharmacol Physiol. 1998 Jun;25(6):405-11. PubMed PMID: 9673814. 16: Kandemir U, Maltepe F, Ugurlu B, Gokmen N, Celik A. The effects of levosimendan and dobutamine in experimental bupivacaine-induced cardiotoxicity. BMC Anesthesiol. 2013 Oct 3;13(1):28. doi: 10.1186/1471-2253-13-28. PubMed PMID: 24088357; PubMed Central PMCID: PMC3852593. 17: Sunny, Yunus M, Karim HM, Saikia MK, Bhattacharyya P, Dey S. Comparison of Levosimendan, Milrinone and Dobutamine in treating Low Cardiac Output Syndrome Following Valve Replacement Surgeries with Cardiopulmonary Bypass. J Clin Diagn Res. 2016 Dec;10(12):UC05-UC08. doi: 10.7860/JCDR/2016/23584.8987. Epub 2016 Dec 1. PubMed PMID: 28208977; PubMed Central PMCID: PMC5296550. 18: Kilbourn RG, Cromeens DM, Chelly FD, Griffith OW. NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs. Crit Care Med. 1994 Nov;22(11):1835-40. PubMed PMID: 7956289. 19: Akagi S, Ogawa A, Miyaji K, Kusano K, Ito H, Matsubara H. Catecholamine support at the initiation of epoprostenol therapy in pulmonary arterial hypertension. Ann Am Thorac Soc. 2014 Jun;11(5):719-27. doi: 10.1513/AnnalsATS.201308-268OC. PubMed PMID: 24716663. 20: Bergh CH, Andersson B, Dahlström U, Forfang K, Kivikko M, Sarapohja T, Ullman B, Wikström G. Intravenous levosimendan vs. dobutamine in acute decompensated heart failure patients on beta-blockers. Eur J Heart Fail. 2010 Apr;12(4):404-10. doi: 10.1093/eurjhf/hfq032. PubMed PMID: 20335355; PubMed Central PMCID: PMC2844760.

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