Synonym
Ciclonicate; Cortofludan; Elastan; Rolil; Vasargil; P-350; P 350; P350;
IUPAC/Chemical Name
(1R,5S)-3,3,5-trimethylcyclohexyl nicotinate
InChi Key
GQSGZTBDVNUIQS-DGCLKSJQSA-N
InChi Code
InChI=1S/C15H21NO2/c1-11-7-13(9-15(2,3)8-11)18-14(17)12-5-4-6-16-10-12/h4-6,10-11,13H,7-9H2,1-3H3/t11-,13-/m1/s1
SMILES Code
O=C(C1=CC=CN=C1)O[C@H]2CC(C)(C)C[C@H](C)C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
247.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Licata G, Pinto A, Parrinello G, Salli L, Indovina I. [Use of ciclonicate in the treatment of obliterative arteriopathies of the lower limbs]. Clin Ter. 1985 Mar 31;112(6):503-13. Italian. PubMed PMID: 4017475.
2: Gregoratti L, Crespi B, Groothold G, Fuligni E, Ghiringhelli L. [Treatment of arteriosclerotic peripheral vascular diseases with ciclonicate]. Minerva Cardioangiol. 1982 Nov;30(11):659-68. Italian. PubMed PMID: 7155375.
3: Feliciotti F, De Carolis G, Mariotti C, Mingolla F. [Clinico-instrumental evaluation of ciclonicate in the therapy of obliterating arteriopathies of the lower extremities in Fontaine's stage II]. Ann Ital Chir. 1983;55(5):493-7. Italian. PubMed PMID: 6673630.
4: Faini D, Pagella PG, Bellavite O, Turba C. Long-lasting antilipolytic action of cyclonicate in rats. Farmaco Prat. 1981 Oct;36(10):478-85. PubMed PMID: 7308421.
5: Alvisi V, Strozzi C. [Clinical evaluation of cyclonicate in atherosclerotic coronary arteriopathy]. Minerva Cardioangiol. 1982 Apr;30(4):209-11. Italian. PubMed PMID: 7088305.
6: Tessari F, Caparrotta L, Gaion RM, Fassina G. Effect of cyclonicate, a new hypolipemic drug, on lipolysis in vitro. Farmaco Sci. 1981 Dec;36(12):1029-36. PubMed PMID: 6274681.