MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 563497 | Name: Bis-T-23
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG 1717, also known as Bis-T-23, is a promoter of actin-dependent dynamin oligomerization. It acts by increasing actin polymerization in injured podocytes.

Chemical Structure

Bis-T-23
Bis-T-23
CAS#171674-76-3

Theoretical Analysis

MedKoo Cat#: 563497

Name: Bis-T-23

CAS#: 171674-76-3

Chemical Formula: C23H20N4O8

Exact Mass: 480.1200

Molecular Weight: 480.43

Elemental Analysis: C, 57.50; H, 4.20; N, 11.66; O, 26.64

Price and Availability

Size Price Availability Quantity
5mg USD 650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Bis-T-23; Bis T-23; Bis T 23; Bis-T 23; AG 1717; AG1717; AG-1717
IUPAC/Chemical Name
(2E,2'E)-N,N'-(propane-1,3-diyl)bis(2-cyano-3-(3,4,5-trihydroxyphenyl)acrylamide)
InChi Key
AAPVOSBVTLGGOU-VHUAAIQRSA-N
InChi Code
InChI=1S/C23H20N4O8/c24-10-14(4-12-6-16(28)20(32)17(29)7-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-8-18(30)21(33)19(31)9-13/h4-9,28-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+
SMILES Code
O=C(NCCCNC(/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1)=O)/C(C#N)=C/C2=CC(O)=C(O)C(O)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 480.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney Int. 2018 Jun;93(6):1298-1307. doi: 10.1016/j.kint.2017.12.028. Epub 2018 Apr 17. Review. PubMed PMID: 29678354; PubMed Central PMCID: PMC5967993. 2: Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H. O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes. Nephrol Dial Transplant. 2017 Sep 1;32(9):1477-1487. doi: 10.1093/ndt/gfw463. PubMed PMID: 28339907. 3: Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, Sever S. Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation. J Am Soc Nephrol. 2017 Feb;28(2):446-451. doi: 10.1681/ASN.2016010008. Epub 2016 Jul 18. PubMed PMID: 27432739; PubMed Central PMCID: PMC5280009. 4: Del Nogal-Avila M, Donoro-Blazquez H, Saha MK, Marshall CB, Clement LC, Macé CE, Chugh SS. Novel therapeutic approaches for chronic kidney disease due to glomerular disorders. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F63-5. doi: 10.1152/ajprenal.00245.2016. Epub 2016 May 4. Review. PubMed PMID: 27147672; PubMed Central PMCID: PMC4967169. 5: Schiffer M, Teng B, Gu C, Shchedrina VA, Kasaikina M, Pham VA, Hanke N, Rong S, Gueler F, Schroder P, Tossidou I, Park JK, Staggs L, Haller H, Erschow S, Hilfiker-Kleiner D, Wei C, Chen C, Tardi N, Hakroush S, Selig MK, Vasilyev A, Merscher S, Reiser J, Sever S. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015 Jun;21(6):601-9. doi: 10.1038/nm.3843. Epub 2015 May 11. PubMed PMID: 25962121; PubMed Central PMCID: PMC4458177. 6: Lees JG, Gorgani NN, Ammit AJ, McCluskey A, Robinson PJ, O'Neill GM. Role of dynamin in elongated cell migration in a 3D matrix. Biochim Biophys Acta. 2015 Mar;1853(3):611-8. doi: 10.1016/j.bbamcr.2014.12.008. Epub 2014 Dec 10. PubMed PMID: 25498249.