MedKoo Cat#: 461390 | Name: Rociverine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rociverine is an anticholinergic agent that is used as a smooth muscle relaxant.

Chemical Structure

Rociverine
Rociverine
CAS#53716-44-2

Theoretical Analysis

MedKoo Cat#: 461390

Name: Rociverine

CAS#: 53716-44-2

Chemical Formula: C20H37NO3

Exact Mass: 339.2773

Molecular Weight: 339.52

Elemental Analysis: C, 70.75; H, 10.98; N, 4.13; O, 14.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Rociverine; Rociverinum;
IUPAC/Chemical Name
1-(diethylamino)propan-2-yl 1-hydroxy-[1,1'-bi(cyclohexane)]-2-carboxylate
InChi Key
XPYLKZZOBVLVHB-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H37NO3/c1-4-21(5-2)15-16(3)24-19(22)18-13-9-10-14-20(18,23)17-11-7-6-8-12-17/h16-18,23H,4-15H2,1-3H3
SMILES Code
O=C(C1C(C2CCCCC2)(O)CCCC1)OC(C)CN(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 339.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cromi A, Ghezzi F, Agosti M, Uccella S, Piazza N, Serati M, Bolis P. Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo-controlled trial. Acta Obstet Gynecol Scand. 2011 Dec;90(12):1371-8. doi: 10.1111/j.1600-0412.2011.01265.x. Epub 2011 Oct 11. PubMed PMID: 21880029. 2: Daccó L, Intrieri L. Rociverine for nocturia in the elderly. Clin Ther. 1986;8(2):170-4. PubMed PMID: 3698063. 3: Hoti E, Censi R, Ricciutelli M, Malaj L, Barboni L, Martelli S, Valleri M, Di Martino P. Validation of an HPLC-MS method for rociverine tablet dissolution analysis. J Pharm Biomed Anal. 2008 Jun 9;47(2):422-8. doi: 10.1016/j.jpba.2008.01.009. Epub 2008 Jan 16. PubMed PMID: 18295427. 4: Subissi A, Maggi CA, Meli A. Rociverine citrate: a new spasmolytic agent, potentially useful in the treatment of urinary bladder hyperreflexia. Jpn J Pharmacol. 1986 Oct;42(2):153-7. PubMed PMID: 3540391. 5: D'Agostino G, Zonta F, Santagostino Barbone MG, Grana E, Brunori P, Subissi A. Mechanism of smooth muscle relaxation by rociverine. Arzneimittelforschung. 1984;34(5):584-9. PubMed PMID: 6540576. 6: Petrillo M, Lazzaroni M, Saponati G, Bianchi Porro G. The use of rociverine as premedication for endoscopy of the upper gastro-intestinal tract: a double-blind controlled clinical trial. Curr Med Res Opin. 1980;7(2):73-6. PubMed PMID: 7002483. 7: Schiantarelli P, Murmann W. Antispasmodic activity of rociverine on the smooth musculature of the urinary tract. Comparative in vitro study. Arzneimittelforschung. 1980;30(7):1102-9. PubMed PMID: 7191292. 8: Schiantarelli P, Murmann W, Magi S. Investigation of rociverine + dipyrone for antispasmodic and analgesic interactions. Arzneimittelforschung. 1979;29(5):760-5. PubMed PMID: 582975. 9: Menicagli S, Lippi A, Criscuoli M, Gervasi PG. Effect of rociverine on P450-dependent monooxygenases and its N-deethylation metabolism in rat liver microsomes. Biochem Pharmacol. 1993 Mar 9;45(5):1097-105. PubMed PMID: 8461039. 10: Pardini M, Saponati G. Lack of effect of a new spasmolytic agent, rociverine, on intraocular pressure, pupil size and iridocorneal angle in patients with angle-closure glaucoma. Pharmatherapeutica. 1983;3(7):445-50. PubMed PMID: 6669589. 11: Coruzzi G, Adami M, Poli E, Bertaccini G. Further observations on the antispasmodic activity of rociverine. Farmaco Prat. 1982 Apr;37(4):109-15. PubMed PMID: 7084440. 12: Daccò L, Barbagallo M, Carbognati A, Girasole G. Rociverine for nocturia in the elderly: medium-term controlled clinical trial. Clin Ther. 1986;8(4):450-8. PubMed PMID: 3524844. 13: Potenzoni D, Zappia L, Sacchini P, Bezzi E. Effects of rociverine on the human ureter: in vivo and in vitro experimental study. Pharmacol Res Commun. 1984 Aug;16(8):765-74. PubMed PMID: 6494219. 14: Modena L. [Treatment of irritable colon syndrome with rociverine]. Minerva Med. 1993 May;84(5):263-8. Italian. PubMed PMID: 8316345. 15: Marsala F. [Therapy of acute spastic pain of the biliary and urinary tracts with rociverine]. Minerva Med. 1982 Sep 8;73(34):2179-82. Italian. PubMed PMID: 7110599. 16: Downie JW, McGuire RP. Antagonism of calcium-induced contraction in potassium-depolarized rabbit detrusor muscle strips by dicyclomine hydrochloride and rociverine. Can J Physiol Pharmacol. 1981 Aug;59(8):853-6. PubMed PMID: 7296384. 17: Testa R, Dellepiane F, Ciravegna G. [Instrumental and clinical study of rociverine]. Clin Ter. 1980 May 15;93(3):311-7. Italian. PubMed PMID: 7449344. 18: Laudi M, Fontana G. Clinical evaluation of a new synthetic spasmolytic (rociverine) in the urological field. Farmaco Prat. 1979 Dec;34(12):553-60. PubMed PMID: 553813. 19: Subissi A, Guelfi M. Effects of rociverine and other spasmolytic agents on caerulein-induced delay in gastric emptying in the conscious rat. Arch Int Pharmacodyn Ther. 1982 May;257(1):130-7. PubMed PMID: 7114969. 20: Manganelli A. Cystometric evaluation of the activity of a new spasmolytic agent - rociverine. Farmaco Prat. 1979 Sep;34(9):384-92. PubMed PMID: 553816.