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MedKoo Cat#: 461387 | Name: Robenidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Robenidine is an anticoccidial guanidine used as an additive in rabbit fodder.

Chemical Structure

Robenidine
Robenidine
CAS#25875-51-8

Theoretical Analysis

MedKoo Cat#: 461387

Name: Robenidine

CAS#: 25875-51-8

Chemical Formula: C15H13Cl2N5

Exact Mass: 333.0548

Molecular Weight: 334.20

Elemental Analysis: C, 53.91; H, 3.92; Cl, 21.21; N, 20.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Robenidine; Khimcoccid; Chimcoccide;
IUPAC/Chemical Name
N',2-bis((E)-4-chlorobenzylidene)hydrazine-1-carboximidhydrazide
InChi Key
MOOFYEJFXBSZGE-LQGKIZFRSA-N
InChi Code
InChI=1S/C15H13Cl2N5/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12/h1-10H,(H3,18,21,22)/b19-9+,20-10+
SMILES Code
N=C(N/N=C/C1=CC=C(Cl)C=C1)N/N=C/C2=CC=C(Cl)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yeom H, Yang DH, Suh JH, Eom HY, Kim U, Kim J, Lee SG, Cho HD, Han SB. Determination of robenidine residues in chicken muscle by high performance liquid chromatography with ultraviolet detection. Arch Pharm Res. 2013 Mar;36(3):359-65. doi: 10.1007/s12272-013-0065-y. Epub 2013 Mar 6. PubMed PMID: 23463333. 2: Abraham RJ, Stevens AJ, Young KA, Russell C, Qvist A, Khazandi M, Wong HS, Abraham S, Ogunniyi AD, Page SW, O'Handley R, McCluskey A, Trott DJ. Robenidine Analogues as Gram-Positive Antibacterial Agents. J Med Chem. 2016 Mar 10;59(5):2126-38. doi: 10.1021/acs.jmedchem.5b01797. Epub 2016 Feb 10. PubMed PMID: 26765953. 3: Liu Y, Wu Y, Jiang Y. [Determination of robenidine residue in chicken tissues and eggs by high performance liquid chromatography]. Se Pu. 2010 Sep;28(9):905-7. Chinese. PubMed PMID: 21171292. 4: Sorribas V, Arruebo MP, Alvarado F, Alcalde AI. Action of robenidine on the intestinal transport and digestion of nutrients in rabbit. Eur J Pharmacol. 1993 Aug 2;248(2):137-44. PubMed PMID: 8223959. 5: Peeters JE, Halen P. Field trial with the coccidiostatics metichlorpindol and robenidine in a rabbit farm. Ann Rech Vet. 1980;11(1):49-55. PubMed PMID: 7436329. 6: Lee EH, Fernando MA. Drug resistance in coccidia: a robenidine-resistant strain of eimeria tenella. Can J Comp Med. 1977 Oct;41(4):466-70. PubMed PMID: 922562; PubMed Central PMCID: PMC1277749. 7: Peeters JE, Geeroms R. Efficacy of diclazuril against robenidine resistant Eimeria magna in rabbits. Vet Rec. 1989 Jun 3;124(22):589-90. PubMed PMID: 2773198. 8: Chapman HD. Eimeria tenella: experimental studies on the development of resistance to robenidine. Parasitology. 1976 Dec;73(3):265-73. PubMed PMID: 1012746. 9: Peeters JE, Halen P, Meulemans G. Efficacy of robenidine in the prevention of rabbit coccidiosis. Br Vet J. 1979 Jul-Aug;135(4):349-54. PubMed PMID: 534928. 10: Peeters JE, Geeroms R, Varewyck H, Bouquet Y, Lampo P, Halen P. Immunity and effect of clopidol/methyl benzoquate and robenidine before and after weaning on rabbit coccidiosis in the field. Res Vet Sci. 1983 Sep;35(2):211-6. PubMed PMID: 6356256. 11: McLoughlin DK, Chute MB. Robenidine resistance in Eimeria tenella. J Parasitol. 1978 Oct;64(5):874-7. PubMed PMID: 722457. 12: Zulalian J, Champagne DA, Wayne RS, Blinn RC. Absorption, excretion, and metabolism of 1,3-bis(p-chlorobenzylideneamino)guanidine hydrochloride (Robenz robenidine hydrochloride) in the chicken. J Agric Food Chem. 1975 Jul-Aug;23(4):724-30. PubMed PMID: 1141522. 13: Smith JE, Pasarela NR, Wyckoff JC. Polarographic determination of robenidine residues in chicken tissues, eggs, litter, soil, and plant tissue. J Assoc Off Anal Chem. 1977 Nov;60(6):1310-7. PubMed PMID: 924934. 14: Zagar JB, Ascione PP, Chrekian GP. Automated high-pressure liquid chromatographic assay of robenidine hydrochloride. J Assoc Off Anal Chem. 1975 Jul;58(4):822-7. PubMed PMID: 1150616. 15: Hansen M, Björklund E, Krogh KA, Brandt A, Halling-Sørensen B. Biotic transformation of anticoccidials in soil using a lab-scale bio-reactor as a precursor-tool. Chemosphere. 2012 Jan;86(2):212-5. doi: 10.1016/j.chemosphere.2011.10.001. Epub 2011 Nov 1. PubMed PMID: 22047618. 16: The determination of robenidine in animal feeds and pre-mixes. Analyst. 1975 Sep;100(1194):668-74. PubMed PMID: 1163797. 17: Peeters JE, Geeroms R, Norton CC. Eimeria magna: resistance against robenidine in the rabbit. Vet Rec. 1987 Dec 5;121(23):545-6. PubMed PMID: 3445427. 18: Liu C, Wang SJ, Zhang Q, Shao YX. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015;64(1):73-9. doi: 10.1538/expanim.14-0064. Epub 2014 Oct 16. PubMed PMID: 25319758; PubMed Central PMCID: PMC4329518. 19: Bakhtari SK, Jíra J. Chemotherapy of experimental toxoplasmosis with special reference to robenidine. Folia Parasitol (Praha). 1988;35(3):193-8. PubMed PMID: 2974008. 20: Tulliez JE, Durand EF, Bories GF. Metabolic fate and pharmacokinetics of tissue residues of the anticoccidial drug robenidine in the rabbit. Incidence of coprophagy on its bioavailability. J Agric Food Chem. 1982 Nov-Dec;30(6):1071-5. PubMed PMID: 6890962.