Robustic acid | CAS#5307-59-5 | coumarin

MedKoo Cat#: 461386 | Name: Robustic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Robustic acid is a coumarin solated from Millettia thonningii.

Chemical Structure

Robustic acid

CAS#5307-59-5

Theoretical Analysis

MedKoo Cat#: 461386

Name: Robustic acid

CAS#: 5307-59-5

Chemical Formula: C22H20O6

Exact Mass: 380.1260

Molecular Weight: 380.39

Elemental Analysis: C, 69.46; H, 5.30; O, 25.24O6

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Robustic acid;

IUPAC/Chemical Name

4-hydroxy-5-methoxy-3-(4-methoxyphenyl)-8,8-dimethyl-2H,8H-pyrano[3,2-g]chromen-2-one

InChi Key

MBZKDBQDALOSRP-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H20O6/c1-22(2)10-9-14-15(28-22)11-16-18(20(14)26-4)19(23)17(21(24)27-16)12-5-7-13(25-3)8-6-12/h5-11,23H,1-4H3

SMILES Code

O=C(O1)C(C2=CC=C(OC)C=C2)=C(O)C(C1=C3)=C(OC)C4=C3OC(C)(C)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 380.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lyddiard JR, Whitfield PJ, Bartlett A. Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae). J Parasitol. 2002 Feb;88(1):163-70. PubMed PMID: 12053958. 2: Yang LF, Wang K, Jiang MG, Liu HC, Wang X, Qin PY, Ouyang QL. Isolation and characterization of a new bioactive isoflavone from Derris eriocarpa. J Asian Nat Prod Res. 2015;17(10):1002-9. doi: 10.1080/10286020.2015.1042370. Epub 2015 Aug 14. PubMed PMID: 26275038. 3: Ayine-Tora DM, Kingsford-Adaboh R, Asomaning WA, Harrison JJ, Mills-Robertson FC, Bukari Y, Sakyi PO, Kaminta S, Reynisson J. Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action. Molecules. 2016 Oct 15;21(10). pii: E1369. PubMed PMID: 27754464. 4: Wang BH, Ternai B, Polya G. Specific inhibition of cyclic AMP-dependent protein kinase by warangalone and robustic acid. Phytochemistry. 1997 Mar;44(5):787-96. PubMed PMID: 9115691. 5: Nkengfack AE, Waffo AK, Azebaze GA, Fomum ZT, Meyer M, Bodo B, van Heerden FR. Indicanine A, a new 3-phenylcoumarin from root bark of Erythrina indica. J Nat Prod. 2000 Jun;63(6):855-6. PubMed PMID: 10869220. 6: Lyddiard JR, Whitfield PJ. Inhibition of Site I mitochondrial electron transport by an extract of the seeds of Millettia thonningii: a potential mechanism for the plant's molluscicidal and schistosome larvicidal activity. J Helminthol. 2001 Sep;75(3):259-65. PubMed PMID: 11551316.