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MedKoo Cat#: 461385 | Name: Robinetin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Robinetin is a therapeutically active plant flavonol from the leaves of Robinia pseudacacia.

Chemical Structure

Robinetin
Robinetin
CAS#490-31-3

Theoretical Analysis

MedKoo Cat#: 461385

Name: Robinetin

CAS#: 490-31-3

Chemical Formula: C15H10O7

Exact Mass: 302.0427

Molecular Weight: 302.23

Elemental Analysis: C, 59.61; H, 3.34; O, 37.05

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 600.00 2 Weeks
50mg USD 1,000.00 2 Weeks
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Related CAS #
No Data
Synonym
Robinetin; Norkanugin;
IUPAC/Chemical Name
3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
InChi Key
SOEDEYVDCDYMMH-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H
SMILES Code
O=C1C(O)=C(C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC=C13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 302.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Ground and excited state proton transfer of the bioactive plant flavonol robinetin in a protein environment: spectroscopic and molecular modeling studies. J Phys Chem B. 2015 Feb 12;119(6):2533-45. doi: 10.1021/jp508410v. Epub 2014 Oct 27. PMID: 25313717. 9: Hanaki M, Murakami K, Gunji H, Irie K. Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis. Bioorg Med Chem Lett. 2022 Apr 1;61:128613. doi: 10.1016/j.bmcl.2022.128613. Epub 2022 Feb 14. PMID: 35176471. 10: Chaudhuri S, Pahari B, Sengupta B, Sengupta PK. Binding of the bioflavonoid robinetin with model membranes and hemoglobin: Inhibition of lipid peroxidation and protein glycosylation. J Photochem Photobiol B. 2010 Jan 21;98(1):12-9. doi: 10.1016/j.jphotobiol.2009.10.002. Epub 2009 Nov 13. PMID: 19914085. 11: Wang Y, Hu Y, Wu T, Zhou X, Shao Y. Triggered Excited-State Intramolecular Proton Transfer Fluorescence for Selective Triplex DNA Recognition. Anal Chem. 2015 Dec 1;87(23):11620-4. doi: 10.1021/acs.analchem.5b02851. Epub 2015 Nov 13. PMID: 26556582. 12: Krüger N, Kronenberger T, Xie H, Rocha C, Pöhlmann S, Su H, Xu Y, Laufer SA, Pillaiyar T. Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19. Pharmaceuticals (Basel). 2023 Jan 28;16(2):190. doi: 10.3390/ph16020190. PMID: 37259339; PMCID: PMC9959258. 13: Takekoshi S, Nagata H, Kitatani K. Flavonoids enhance melanogenesis in human melanoma cells. Tokai J Exp Clin Med. 2014 Sep 20;39(3):116-21. PMID: 25248426. 14: Asif H, Alamgeer, Bukhari IA, Vohra F, Afzal S, Khan SW, Niazi ZR. Phytochemical analysis of crude extract of Delphinium brunonianum and its effect on hypertension and metabolic perturbations in fructose fed rats. Nat Prod Res. 2021 Sep;35(17):2982-2986. doi: 10.1080/14786419.2019.1679134. Epub 2019 Nov 1. PMID: 31674843. 15: Nasir H, Iqbal Z, Hiradate S, Fujii Y. Allelopathic potential of Robinia pseudo-acacia L. J Chem Ecol. 2005 Sep;31(9):2179-92. doi: 10.1007/s10886-005-6084-5. Epub 2005 Aug 17. PMID: 16132219. 16: Jahangeer M, Mustafa G, Munir N, Ahmed S, Al-Anazi KM. Exploring the Potential of Plant Bioactive Compounds against Male Infertility: An In Silico and In Vivo Study. Molecules. 2023 Nov 21;28(23):7693. doi: 10.3390/molecules28237693. PMID: 38067423; PMCID: PMC10707554. 17: Chang RL, Huang MT, Wood AW, Wong CQ, Newmark HL, Yagi H, Sayer JM, Jerina DM, Conney AH. Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse. Carcinogenesis. 1985 Aug;6(8):1127-33. doi: 10.1093/carcin/6.8.1127. PMID: 3926336. 18: Añón MT, Ubeda A, Alcaraz MJ. Protective effects of phenolic compounds on CCl4-induced toxicity in isolated rat hepatocytes. Z Naturforsch C J Biosci. 1992 Mar-Apr;47(3-4):275-9. doi: 10.1515/znc-1992-3-417. 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