FMHM | CAS#1426543-96-5 | TRAF6 scavenging agent

MedKoo Cat#: 563485 | Name: FMHM

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FMHM is a TRAF6 scavenging agent via ubiquitination-dependent mode.

Chemical Structure

FMHM

CAS#1426543-96-5

Theoretical Analysis

MedKoo Cat#: 563485

Name: FMHM

CAS#: 1426543-96-5

Chemical Formula: C11H12O5

Exact Mass: 224.0685

Molecular Weight: 224.21

Elemental Analysis: C, 58.93; H, 5.39; O, 35.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

FMHM;

IUPAC/Chemical Name

(5-Formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate

InChi Key

DVEBNONPNBAGBE-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H12O5/c1-8(4-5-12)11(14)15-7-10-3-2-9(6-13)16-10/h2-3,6,12H,1,4-5,7H2

SMILES Code

O=C(OCC1=CC=C(C=O)O1)C(CCO)=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 224.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zeng KW, Liao LX, Lv HN, Song FJ, Yu Q, Dong X, Li J, Jiang Y, Tu PF. Natural small molecule FMHM inhibits lipopolysaccharide-induced inflammatory response by promoting TRAF6 degradation via K48-linked polyubiquitination. Sci Rep. 2015 Oct 1;5:14715. doi: 10.1038/srep14715. PubMed PMID: 26423026; PubMed Central PMCID: PMC4589686. 2: Zeng KW, Li J, Dong X, Wang YH, Ma ZZ, Jiang Y, Jin HW, Tu PF. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-κB and MAPK pathways. Toxicol Appl Pharmacol. 2013 Nov 15;273(1):159-71. doi: 10.1016/j.taap.2013.08.028. Epub 2013 Sep 7. PubMed PMID: 24021941. 3: Ventura C, Cantoni S, Bianchi F, Lionetti V, Cavallini C, Scarlata I, Foroni L, Maioli M, Bonsi L, Alviano F, Fossati V, Bagnara GP, Pasquinelli G, Recchia FA, Perbellini A. Hyaluronan mixed esters of butyric and retinoic Acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts. J Biol Chem. 2007 May 11;282(19):14243-52. Epub 2007 Mar 15. PubMed PMID: 17363374. 4: Westerberg VS, Geiger JD. Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat. Pharmacol Biochem Behav. 1987 Nov;28(3):419-22. PubMed PMID: 3685079.