MedKoo Cat#: 563483 | Name: MNS
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MNS is a selective inhibitor of Syk kinase activity. It acts by inhibiting NLRP3 ATPase activity and binding to the NACHT and LRR domains.

Chemical Structure

MNS
CAS#1485-00-3

Theoretical Analysis

MedKoo Cat#: 563483

Name: MNS

CAS#: 1485-00-3

Chemical Formula: C9H7NO4

Exact Mass: 193.0375

Molecular Weight: 193.15

Elemental Analysis: C, 55.96; H, 3.65; N, 7.25; O, 33.13

Price and Availability

Size Price Availability Quantity
10mg USD 230.00
50mg USD 370.00
100mg USD 590.00
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Related CAS #
No Data
Synonym
MNS; SYK Inhibitor III;
IUPAC/Chemical Name
(E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole
InChi Key
KFLWBZPSJQPRDD-ONEGZZNKSA-N
InChi Code
InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3+
SMILES Code
O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 193.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bao BQ, Le NH, Nguyen DHT, Tran TV, Pham LPT, Bach LG, Ho HM, Nguyen TH, Nguyen DH. Evolution and present scenario of multifunctionalized mesoporous nanosilica platform: A mini review. Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:912-928. doi: 10.1016/j.msec.2018.07.008. Epub 2018 Jul 7. Review. PubMed PMID: 30033325. 2: Khalil R, Tindle R, Boraud T, Moustafa AA, Karim AA. Social decision making in autism: On the impact of mirror neurons, motor control, and imitative behaviors. CNS Neurosci Ther. 2018 Aug;24(8):669-676. doi: 10.1111/cns.13001. Epub 2018 Jul 2. Review. PubMed PMID: 29963752; PubMed Central PMCID: PMC6055683. 3: Saleh RM, Zefarina Z, Che Mat NF, Chambers GK, Edinur HA. Transfusion Medicine and Molecular Genetic Methods. Int J Prev Med. 2018 May 16;9:45. doi: 10.4103/ijpvm.IJPVM_232_16. eCollection 2018. Review. PubMed PMID: 29899883; PubMed Central PMCID: PMC5981227. 4: Xie K, Sheppard A. Dietary Micronutrients Promote Neuronal Differentiation by Modulating the Mitochondrial-Nuclear Dialogue. Bioessays. 2018 Jul;40(7):e1800051. doi: 10.1002/bies.201800051. Epub 2018 Jun 7. Review. PubMed PMID: 29878388. 5: Fogarty MJ. Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis. Brain Res Bull. 2018 Jun;140:318-333. doi: 10.1016/j.brainresbull.2018.05.023. Epub 2018 Jun 2. Review. PubMed PMID: 29870780. 6: Aziz-Zadeh L, Kilroy E, Corcelli G. Understanding Activation Patterns in Shared Circuits: Toward a Value Driven Model. Front Hum Neurosci. 2018 May 7;12:180. doi: 10.3389/fnhum.2018.00180. eCollection 2018. Review. PubMed PMID: 29867409; PubMed Central PMCID: PMC5949354. 7: Zhang JJQ, Fong KNK, Welage N, Liu KPY. The Activation of the Mirror Neuron System during Action Observation and Action Execution with Mirror Visual Feedback in Stroke: A Systematic Review. Neural Plast. 2018 Apr 24;2018:2321045. doi: 10.1155/2018/2321045. eCollection 2018. Review. PubMed PMID: 29853839; PubMed Central PMCID: PMC5941778. 8: Riancho J, Bosque-Varela P, Perez-Pereda S, Povedano M, de Munaín AL, Santurtun A. The increasing importance of environmental conditions in amyotrophic lateral sclerosis. Int J Biometeorol. 2018 Apr 30. doi: 10.1007/s00484-018-1550-2. [Epub ahead of print] Review. PubMed PMID: 29713861. 9: Jin X, Zhu DD, Chen BZ, Ashfaq M, Guo XD. Insulin delivery systems combined with microneedle technology. Adv Drug Deliv Rev. 2018 Mar 1;127:119-137. doi: 10.1016/j.addr.2018.03.011. Epub 2018 Mar 29. Review. PubMed PMID: 29604374. 10: Wu C, Shen Y, Chen M, Wang K, Li Y, Cheng Y. Recent Advances in Magnetic-Nanomaterial-Based Mechanotransduction for Cell Fate Regulation. Adv Mater. 2018 Apr;30(17):e1705673. doi: 10.1002/adma.201705673. Epub 2018 Mar 15. Review. PubMed PMID: 29543348. 11: Iyer AK, Jones KJ, Sanders VM, Walker CL. Temporospatial Analysis and New Players in the Immunology of Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2018 Feb 23;19(2). pii: E631. doi: 10.3390/ijms19020631. Review. PubMed PMID: 29473876; PubMed Central PMCID: PMC5855853. 12: Zaina M, Bressan V, Caporale L. [How the bed rest period and the posture assumed by the patient post lumbar puncture caninfluence the onset of complications: a rapid evidence assessment]. Prof Inferm. 2017 Oct-Dec;70(4):222-230. doi: 10.7429/pi.2017.704222. Review. Italian. PubMed PMID: 29460559. 13: Ye Y, Yu J, Wen D, Kahkoska AR, Gu Z. Polymeric microneedles for transdermal protein delivery. Adv Drug Deliv Rev. 2018 Mar 1;127:106-118. doi: 10.1016/j.addr.2018.01.015. Epub 2018 Jan 31. Review. PubMed PMID: 29408182; PubMed Central PMCID: PMC6020694. 14: Jeon H, Lee SH. From Neurons to Social Beings: Short Review of the Mirror Neuron System Research and Its Socio-Psychological and Psychiatric Implications. Clin Psychopharmacol Neurosci. 2018 Feb 28;16(1):18-31. doi: 10.9758/cpn.2018.16.1.18. Review. PubMed PMID: 29397663; PubMed Central PMCID: PMC5810456. 15: O'Connell JE, Bourke B, Kearns GJ. Orthognathic surgery in Melnick-Needles syndrome: a review of the literature and report of two siblings. Int J Oral Maxillofac Surg. 2018 Jun;47(6):738-742. doi: 10.1016/j.ijom.2017.12.001. Epub 2018 Jan 12. Review. PubMed PMID: 29336932. 16: Maurel C, Dangoumau A, Marouillat S, Brulard C, Chami A, Hergesheimer R, Corcia P, Blasco H, Andres CR, Vourc'h P. Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration. Mol Neurobiol. 2018 Aug;55(8):6480-6499. doi: 10.1007/s12035-017-0856-0. Epub 2018 Jan 10. Review. PubMed PMID: 29322304. 17: Govoni A, Gagliardi D, Comi GP, Corti S. Time Is Motor Neuron: Therapeutic Window and Its Correlation with Pathogenetic Mechanisms in Spinal Muscular Atrophy. Mol Neurobiol. 2018 Aug;55(8):6307-6318. doi: 10.1007/s12035-017-0831-9. Epub 2018 Jan 2. Review. PubMed PMID: 29294245. 18: Guha TK, Edgell DR. Applications of Alternative Nucleases in the Age of CRISPR/Cas9. Int J Mol Sci. 2017 Nov 29;18(12). pii: E2565. doi: 10.3390/ijms18122565. Review. PubMed PMID: 29186020; PubMed Central PMCID: PMC5751168. 19: Chiarotto GB, Nardo G, Trolese MC, França MC Jr, Bendotti C, Rodrigues de Oliveira AL. The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2017 Nov 1;18(11). pii: E2298. doi: 10.3390/ijms18112298. Review. PubMed PMID: 29104236; PubMed Central PMCID: PMC5713268. 20: Donnelly RF, Larrañeta E. Microarray patches: potentially useful delivery systems for long-acting nanosuspensions. Drug Discov Today. 2018 May;23(5):1026-1033. doi: 10.1016/j.drudis.2017.10.013. Epub 2017 Oct 23. Review. PubMed PMID: 29074440.