MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 563482 | Name: DIDS

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DIDS is a RAD51 inhibitor and anion exchange inhibitor. It acts by blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.

Chemical Structure

DIDS
CAS#53005-05-3

Theoretical Analysis

MedKoo Cat#: 563482

Name: DIDS

CAS#: 53005-05-3

Chemical Formula: C16H10N2O6S4

Exact Mass: 453.9422

Molecular Weight: 454.50

Elemental Analysis: C, 42.28; H, 2.22; N, 6.16; O, 21.12; S, 28.22

Price and Availability

Size Price Availability Quantity
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
DIDS;
IUPAC/Chemical Name
(E)-6,6'-(ethene-1,2-diyl)bis(3-isothiocyanatobenzenesulfonic acid)
InChi Key
YSCNMFDFYJUPEF-OWOJBTEDSA-N
InChi Code
InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
SMILES Code
O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)(O)=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 454.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Q, Jing H, Su HC. Recent Advances in DOCK8 Immunodeficiency Syndrome. J Clin Immunol. 2016 Jul;36(5):441-9. doi: 10.1007/s10875-016-0296-z. Epub 2016 May 20. Review. PubMed PMID: 27207373; PubMed Central PMCID: PMC4914394. 2: Thinnes FP. Opening up of plasmalemma type-1 VDAC to form apoptotic "find me signal" pathways is essential in early apoptosis - evidence from the pathogenesis of cystic fibrosis resulting from failure of apoptotic cell clearance followed by sterile inflammation. Mol Genet Metab. 2014 Apr;111(4):439-44. doi: 10.1016/j.ymgme.2014.02.001. Epub 2014 Feb 13. Review. PubMed PMID: 24613483. 3: DiNuzzo M, Mangia S, Maraviglia B, Giove F. Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes. Neurochem Int. 2013 Nov;63(5):458-64. doi: 10.1016/j.neuint.2013.08.004. Epub 2013 Aug 19. Review. PubMed PMID: 23968961; PubMed Central PMCID: PMC4082998. 4: Liu Z, Liu L, Zhang Z, Chen Z, Zhao B. Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD008184. doi: 10.1002/14651858.CD008184.pub2. Review. PubMed PMID: 23633351. 5: Romero MF, Chen AP, Parker MD, Boron WF. The SLC4 family of bicarbonate (HCO₃⁻) transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):159-82. doi: 10.1016/j.mam.2012.10.008. Review. PubMed PMID: 23506864; PubMed Central PMCID: PMC3605756. 6: Dahl G, Qiu F, Wang J. The bizarre pharmacology of the ATP release channel pannexin1. Neuropharmacology. 2013 Dec;75:583-93. doi: 10.1016/j.neuropharm.2013.02.019. Epub 2013 Mar 13. Review. PubMed PMID: 23499662; PubMed Central PMCID: PMC3711969. 7: Markovich D. Sodium-sulfate/carboxylate cotransporters (SLC13). Curr Top Membr. 2012;70:239-56. doi: 10.1016/B978-0-12-394316-3.00007-7. Review. PubMed PMID: 23177988. 8: Shennan DB. Placental sulphate transport: a review of functional and molecular studies. Placenta. 2012 Aug;33(8):599-603. doi: 10.1016/j.placenta.2012.04.008. Epub 2012 May 12. Review. PubMed PMID: 22578714. 9: Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM. Anoctamins and gastrointestinal smooth muscle excitability. Exp Physiol. 2012 Feb;97(2):200-6. doi: 10.1113/expphysiol.2011.058248. Epub 2011 Oct 14. Review. PubMed PMID: 22002868; PubMed Central PMCID: PMC3272164. 10: Szentandrássy N, Nagy D, Ruzsnavszky F, Harmati G, Bányász T, Magyar J, Szentmiklósi AJ, Nánási PP. Powerful technique to test selectivity of agents acting on cardiac ion channels: the action potential voltage-clamp. Curr Med Chem. 2011;18(24):3737-56. Review. PubMed PMID: 21774754. 11: Zhang Q, Davis JC, Dove CG, Su HC. Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome. Dis Markers. 2010;29(3-4):131-9. doi: 10.3233/DMA-2010-0737. Review. PubMed PMID: 21178272; PubMed Central PMCID: PMC3835385. 12: Alper SL. Molecular physiology and genetics of Na+-independent SLC4 anion exchangers. J Exp Biol. 2009 Jun;212(Pt 11):1672-83. doi: 10.1242/jeb.029454. Review. PubMed PMID: 19448077; PubMed Central PMCID: PMC2683012. 13: Onken H, Moffett DF. Revisiting the cellular mechanisms of strong luminal alkalinization in the anterior midgut of larval mosquitoes. J Exp Biol. 2009 Feb;212(Pt 3):373-7. doi: 10.1242/jeb.023580. Review. PubMed PMID: 19151212; PubMed Central PMCID: PMC2706088. 14: Chen B, Nicol G, Cho WK. Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line. J Membr Biol. 2007 Jan;215(1):1-13. Epub 2007 May 5. Review. PubMed PMID: 17483866. 15: Jakab M, Schmidt S, Grundbichler M, Paulmichl M, Hermann A, Weiger T, Ritter M. Hypotonicity and ethanol modulate BK channel activity and chloride currents in GH4/C1 pituitary tumour cells. Acta Physiol (Oxf). 2006 May-Jun;187(1-2):51-9. Review. PubMed PMID: 16734742. 16: Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol. 2006 Jan;91(1):153-61. Epub 2005 Oct 20. Review. Erratum in: Exp Physiol. 2006 Mar;91(2):481. PubMed PMID: 16239253. 17: Pusch M, Zifarelli G, Murgia AR, Picollo A, Babini E. Channel or transporter? The CLC saga continues. Exp Physiol. 2006 Jan;91(1):149-52. Epub 2005 Sep 22. Review. PubMed PMID: 16179405. 18: Romero MF, Fulton CM, Boron WF. The SLC4 family of HCO 3 - transporters. Pflugers Arch. 2004 Feb;447(5):495-509. Epub 2004 Jan 14. Review. PubMed PMID: 14722772. 19: Kito Y, Suzuki H. Electrophysiological properties of gastric pacemaker potentials. J Smooth Muscle Res. 2003 Oct;39(5):163-73. Review. PubMed PMID: 14695027. 20: Markovich D, Murer H. The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch. 2004 Feb;447(5):594-602. Epub 2003 Aug 12. Review. Erratum in: Pflugers Arch. 2004 Feb;447(5):816-7. PubMed PMID: 12915942.