MedKoo Cat#: 598673 | Name: Leucopyrokinin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucopyrokinin is a myotropic neuropeptide from Madeira cockroach Leucophaea maderae.

Chemical Structure

Leucopyrokinin
CAS#104052-00-8

Theoretical Analysis

MedKoo Cat#: 598673

Name: Leucopyrokinin

CAS#: 104052-00-8

Chemical Formula: C42H66N12O12

Exact Mass: 930.4923

Molecular Weight: 931.06

Elemental Analysis: C, 54.18; H, 7.15; N, 18.05; O, 20.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Leucopyrokinin; Pglu-thr-ser-phe-thr-pro-arg-leu-NH2;
IUPAC/Chemical Name
(S)-N-((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-threonyl-L-seryl-L-phenylalanyl-L-threonyl)pyrrolidine-2-carboxamide
InChi Key
NEKVWFJBFXHZFD-SIDKUONNSA-N
InChi Code
InChI=1S/C42H66N12O12/c1-21(2)18-27(34(43)59)49-35(60)25(12-8-16-46-42(44)45)48-39(64)30-13-9-17-54(30)41(66)33(23(4)57)53-37(62)28(19-24-10-6-5-7-11-24)50-38(63)29(20-55)51-40(65)32(22(3)56)52-36(61)26-14-15-31(58)47-26/h5-7,10-11,21-23,25-30,32-33,55-57H,8-9,12-20H2,1-4H3,(H2,43,59)(H,47,58)(H,48,64)(H,49,60)(H,50,63)(H,51,65)(H,52,61)(H,53,62)(H4,44,45,46)/t22-,23-,25+,26+,27+,28+,29+,30+,32+,33+/m1/s1
SMILES Code
O=C(CC1)N[C@@H]1C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](Cc2ccccc2)C(N[C@@H]([C@H](O)C)C(N(CCC3)[C@@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 931.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ryszka F, Dolińska B, Suszka-Świtek A, Rykaczewska-Czerwińska M, Konopińska D, Kuczer M, Plech A. Distribution in Rats Internal Organs of Intraperitoneally Given 125I-Labeled Heptapeptide [2-8]-Leucopyrokinin ([2-8]-LPK), a Truncated Analog of Insect Neuropeptide Leucopyrokinin. Adv Clin Exp Med. 2015 Jul-Aug;24(4):579-84. doi: 10.17219/acem/24503. PubMed PMID: 26469101. 2: Plech A, Rykaczewska-Czerwińska M, Bartosz-Bechowski H, Lombarska-Sliwińska D, Małota M, Szewczyk M, Brus R, Konopińska D. Insect neuropeptide leucopyrokinin analogues--synthesis and antinociceptive effect in rats. Pol J Pharmacol. 1997 Mar-Jun;49(2-3):119-26. PubMed PMID: 9437758. 3: Plech A, Rykaczewska-Czerwińska M, Konopińska D. Leucopyrokinin (LPK) analog [d-Ala(5)]-[2-8]-LPK inhibits LPK-induced analgesia in rats. Peptides. 2004 Jun;25(6):1005-11. PubMed PMID: 15203248. 4: Plech A, Rykaczewska-Czerwińska M, Ryszka F, Suszka-Switek A, Dolińska B, Konopińska D. Distribution of 125I-labeled [2-8]-leucopyrokinin, active analog of leucopyrokinin in rats. Acta Pol Pharm. 2005 Sep-Oct;62(5):393-7. PubMed PMID: 16459488. 5: Plech A, Rykaczewska-Czerwińska M, Ryszka F, Suszka-Switek A, Dolińska B, Konopińska D. Distribution of 125J-labeled leucopyrokinin (LPK) in rats. Int J Tissue React. 2003;25(2):65-71. PubMed PMID: 14518595. 6: Rykaczewska-Czerwińska M, Konopińska D, Plech A. The effect of the leucopyrokinin analogue: [2-8]-leucopyrokinin on central opioid receptors in rats. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Nov;130(3):271-9. PubMed PMID: 11701384. 7: Nachman RJ, Holman GM, Cook BJ. Active fragments and analogs of the insect neuropeptide leucopyrokinin: structure-function studies. Biochem Biophys Res Commun. 1986 Jun 30;137(3):936-42. PubMed PMID: 3015140. 8: Matsumoto S, Fónagy A, Kurihara M, Uchiumi K, Nagamine T, Chijimatsu M, Mitsui T. Isolation and primary structure of a novel pheromonotropic neuropeptide structurally related to leucopyrokinin from the armyworm larvae, Pseudaletia separata. Biochem Biophys Res Commun. 1992 Jan 31;182(2):534-9. PubMed PMID: 1734867. 9: Zd'árek J, Myska P, Zemek R, Nachman RJ. Mode of action of an insect neuropeptide leucopyrokinin (LPK) on pupariation in fleshfly (Sarcophaga bullata) larvae (Diptera: Sarcophagidae). J Insect Physiol. 2002 Oct;48(10):951-959. PubMed PMID: 12770042. 10: Nachman RJ, Teal PE, Aziz OB, Davidovitch M, Zubrzak P, Altstein M. An amphiphilic, PK/PBAN analog is a selective pheromonotropic antagonist that penetrates the cuticle of a heliothine insect. Peptides. 2009 Mar;30(3):616-21. doi: 10.1016/j.peptides.2008.09.024. Epub 2008 Oct 17. PubMed PMID: 18992778. 11: Abdoun K, Mesnier-Sabin M, Baudry-Partiaoglou N, Nicolas P, Cohen P. Separation of oviposition-stimulating peptides and myotropic factors from head extracts of Galleria mellonella L.: comparative effects of myotropic and non-myotropic factors on egg laying. J Comp Physiol B. 1995;165(2):102-9. PubMed PMID: 7622672. 12: Hendrich AB, Konopinska D. Interactions of selected insect neuropeptides with synthetic lipids. Gen Physiol Biophys. 1992 Jun;11(3):251-60. PubMed PMID: 1426975. 13: Schoofs L, Holman GM, Hayes TK, Tips A, Nachman RJ, Vandesande F, De Loof A. Isolation, identification and synthesis of locustamyotropin (Lom-MT), a novel biologically active insect peptide. Peptides. 1990 May-Jun;11(3):427-33. PubMed PMID: 1974346. 14: Masler EP, Raina AK, Wagner RM, Kochansky JP. Isolation and identification of a pheromonotropic neuropeptide from the brain-suboesophageal ganglion complex of Lymantria dispar: a new member of the PBAN family. Insect Biochem Mol Biol. 1994 Sep;24(8):829-36. PubMed PMID: 7981730. 15: Nachman RJ, Holman GM, Schoofs L, Yamashita O. Silkworm diapause induction activity of myotropic pyrokinin (FXPRLamide) insect neuropeptides. Peptides. 1993 Sep-Oct;14(5):1043-8. PubMed PMID: 8284254. 16: Schoofs L, Holman GM, Hayes TK, Nachman RJ, De Loof A. Isolation, primary structure, and synthesis of locustapyrokinin: a myotropic peptide of Locusta migratoria. Gen Comp Endocrinol. 1991 Jan;81(1):97-104. PubMed PMID: 2026322. 17: Holman GM, Nachman RJ, Wright MS. Comparative aspects of insect myotropic peptides. Prog Clin Biol Res. 1990;342:35-9. PubMed PMID: 2381948. 18: Harshini S, Nachman RJ, Sreekumar S. Inhibition of digestive enzyme release by neuropeptides in larvae of Opisina arenosella (Lepidoptera: Cryptophasidae). Comp Biochem Physiol B Biochem Mol Biol. 2002 Jun;132(2):353-8. PubMed PMID: 12031460. 19: Kuniyoshi H, Nagasawa H, Ando T, Suzuki A, Nachman RJ, Holman GM. Cross-activity between pheromone biosynthesis activating neuropeptide (PBAN) and myotropic pyrokinin insect peptides. Biosci Biotechnol Biochem. 1992 Jan;56(1):167-8. PubMed PMID: 1368132. 20: Saideman SR, Ma M, Kutz-Naber KK, Cook A, Torfs P, Schoofs L, Li L, Nusbaum MP. Modulation of rhythmic motor activity by pyrokinin peptides. J Neurophysiol. 2007 Jan;97(1):579-95. Epub 2006 Oct 25. PubMed PMID: 17065249.