Schistoflrfamide | CAS#121801-61-4 | locust myosuppressin

MedKoo Cat#: 598667 | Name: Schistoflrfamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Schistoflrfamide is a locust myosuppressin isolated from the thoracic nervous system of the locust Schistocerca gregaria.

Chemical Structure

Schistoflrfamide

CAS#121801-61-4

Theoretical Analysis

MedKoo Cat#: 598667

Name: Schistoflrfamide

CAS#: 121801-61-4

Chemical Formula: C59H86N16O14

Exact Mass: 1242.6509

Molecular Weight: 1243.43

Elemental Analysis: C, 56.99; H, 6.97; N, 18.02; O, 18.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Schistoflrfamide; Pdvdhvflrfamide; Pro-asp-val-asp-his-val-phe-leu-arg-phe-NH2; 1-L-Prolineleucomyosuppressin;

IUPAC/Chemical Name

(6S,9S,12S,15S,18R,21S,24S,27S)-18-((1H-imidazol-5-yl)methyl)-1-amino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-12-benzyl-21-(carboxymethyl)-1-imino-9-isobutyl-15,24-diisopropyl-8,11,14,17,20,23,26-heptaoxo-27-((S)-pyrrolidine-2-carboxamido)-2,7,10,13,16,19,22,25-octaazanonacosan-29-oic acid

InChi Key

MXQCHKYVLFWFJG-AFJQEWLFSA-N

InChi Code

1S/C59H86N16O14/c1-31(2)23-40(52(83)67-38(20-14-22-65-59(61)62)51(82)68-39(49(60)80)24-34-15-9-7-10-16-34)69-53(84)41(25-35-17-11-8-12-18-35)72-57(88)47(32(3)4)74-55(86)42(26-36-29-63-30-66-36)70-54(85)43(27-45(76)77)73-58(89)48(33(5)6)75-56(87)44(28-46(78)79)71-50(81)37-19-13-21-64-37/h7-12,15-18,29-33,37-44,47-48,64H,13-14,19-28H2,1-6H3,(H2,60,80)(H,63,66)(H,67,83)(H,68,82)(H,69,84)(H,70,85)(H,71,81)(H,72,88)(H,73,89)(H,74,86)(H,75,87)(H,76,77)(H,78,79)(H4,61,62,65)/t37-,38-,39-,40-,41-,42+,43-,44-,47-,48-/m0/s1

SMILES Code

CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1)=O)CC(O)=O)=O)C(C)C)=O)CC(O)=O)=O)Cc2[nH]cnc2)=O)C(C)C)=O)Cc3ccccc3)=O)C(N[C@H](C(N[C@H](C(N)=O)Cc4ccccc4)=O)CCCNC(N)=N)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,243.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sedra L, Haddad AS, Lange AB. Myoinhibitors controlling oviduct contraction within the female blood-gorging insect, Rhodnius prolixus. Gen Comp Endocrinol. 2015 Jan 15;211:62-8. doi: 10.1016/j.ygcen.2014.11.019. Epub 2014 Dec 4. PubMed PMID: 25482544. 2: Robb S, Evans P. THE MODULATORY EFFECT OF SCHISTOFLRFamide ON HEART AND SKELETAL MUSCLE IN THE LOCUST SCHISTOCERCA GREGARIA. J Exp Biol. 1994 Dec;197(1):437-42. PubMed PMID: 9318083. 3: Hill SR, Orchard I. In vitro analysis of the digestive enzymes amylase and alpha-glucosidase in the midguts of Locusta migratoria L. in response to the myosuppressin, SchistoFLRFamide. J Insect Physiol. 2005 Jan;51(1):1-9. PubMed PMID: 15686640. 4: Schoofs L, Holman GM, Paemen L, Veelaert D, Amelinckx M, De Loof A. Isolation, identification, and synthesis of PDVDHFLRFamide (SchistoFLRFamide) in Locusta migratoria and its association with the male accessory glands, the salivary glands, the heart, and the oviduct. Peptides. 1993 May-Jun;14(3):409-21. PubMed PMID: 7687352. 5: Kwok R, Orchard I. Characterization of a putative SchistoFLRFamide receptor in the CNS of Locusta migratoria. Peptides. 2002 Apr;23(4):765-72. PubMed PMID: 11897396. 6: Swales LS, Evans PD. Distribution of SchistoFLRFamide-like immunoreactivity in the adult ventral nervous system of the locust, Schistocerca gregaria. Cell Tissue Res. 1995 Aug;281(2):339-48. PubMed PMID: 7648627. 7: Vullings HG, Ten Voorde SE, Passier PC, Diederen JH, Van Der Horst DJ, Nässel DR. A possible role of SchistoFLRFamide in inhibition of adipokinetic hormone release from locust corpora cardiaca. J Neurocytol. 1998 Dec;27(12):901-13. PubMed PMID: 10659682. 8: Wang Z, Orchard I, Lange AB, Chen X. Mode of action of an inhibitory neuropeptide SchistoFLRFamide on the locust oviduct visceral muscle. Neuropeptides. 1995 Mar;28(3):147-55. PubMed PMID: 7791958. 9: Wang Z, Orchard I, Lange AB. Identification and characterization of two receptors for SchistoFLRFamide on locust oviduct. Peptides. 1994;15(5):875-82. PubMed PMID: 7984508. 10: Lange AB, Orchard I, Wang Z, Nachman RJ. A nonpeptide agonist of the invertebrate receptor for SchistoFLRFamide (PDVDHVFLRFamide), a member of a subfamily of insect FMRFamide-related peptides. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9250-3. PubMed PMID: 7568111; PubMed Central PMCID: PMC40962. 11: Kwok R, Orchard I. Central effects of the peptides, SchistoFLRFamide and proctolin, on locust oviduct contraction. Peptides. 2002 Nov;23(11):1925-32. PubMed PMID: 12431730. 12: Lange AB, Orchard I. The effects of SchistoFLRFamide on contractions of locust midgut. Peptides. 1998;19(3):459-67. PubMed PMID: 9533633. 13: Wang Z, Orchard I, Lange AB, Chen X. Binding and activation regions of the decapeptide PDVDHVFLRFamide (SchistoFLRFamide). Neuropeptides. 1995 May;28(5):261-6. PubMed PMID: 7603586. 14: Clark J, Lange AB. Octopamine modulates spermathecal muscle contractions in Locusta migratoria. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2003 Feb;189(2):105-14. Epub 2002 Dec 20. PubMed PMID: 12607039. 15: Lange AB, Cheung IL. The modulation of skeletal muscle contraction by FMRFamide-related peptides of the locust. Peptides. 1999 Dec;20(12):1411-8. PubMed PMID: 10698115. 16: Mousley A, Marks NJ, Halton DW, Geary TG, Thompson DP, Maule AG. Arthropod FMRFamide-related peptides modulate muscle activity in helminths. Int J Parasitol. 2004 May;34(6):755-68. PubMed PMID: 15111097. 17: Gray AS, Hancock JT, Osborne RH. Proctolin antagonists bind to [(3)H]proctolin binding sites in the locust hindgut. Peptides. 2000 Feb;21(2):189-96. PubMed PMID: 10764944. 18: Hill SR, Orchard I. Isolation and sequencing of two FMRFamide-related peptides from the gut of Locusta migratoria L. Peptides. 2007 Aug;28(8):1490-7. Epub 2007 Jun 22. PubMed PMID: 17707763. 19: Clark J, Lange AB. Evidence for the association of FMRFamide-related peptides with the spermatheca of Locusta migratoria. Peptides. 2002 Apr;23(4):613-9. PubMed PMID: 11897379. 20: Wang Z, Orchard I, Lange AB. Binding affinity and physiological activity of some HVFLRFamide analogues on the oviducts of the locust, Locusta migratoria. Regul Pept. 1995 Jun 27;57(3):339-46. PubMed PMID: 7480883.