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MedKoo Cat#: 598663 | Name: Maridomycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Maridomycin is a Macrolide antibiotic.

Chemical Structure

Maridomycin
Maridomycin
CAS#35775-82-7

Theoretical Analysis

MedKoo Cat#: 598663

Name: Maridomycin

CAS#: 35775-82-7

Chemical Formula: C41H67NO15

Exact Mass: 813.4511

Molecular Weight: 813.97

Elemental Analysis: C, 60.50; H, 8.30; N, 1.72; O, 29.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Maridomycin; Turimycin EP(sub 3); Maridomycin III;
IUPAC/Chemical Name
(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-(((1S,3R,7R,8S,9S,10R,12R,13R,16S,E)-13-hydroxy-8-methoxy-3,12-dimethyl-5-oxo-10-(2-oxoethyl)-7-propionyl-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl propionate
InChi Key
OFBDKNBXULFDFN-FSNMLSSTSA-N
InChi Code
InChI=1S/C41H67NO15/c1-11-27(44)26-19-32(47)51-22(4)18-30-29(54-30)14-13-28(45)21(3)17-25(15-16-43)37(38(26)50-10)57-40-35(48)34(42(8)9)36(23(5)53-40)56-33-20-41(7,49)39(24(6)52-33)55-31(46)12-2/h13-14,16,21-26,28-30,33-40,45,48-49H,11-12,15,17-20H2,1-10H3/b14-13+/t21-,22-,23-,24+,25+,26+,28+,29+,30+,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1
SMILES Code
O=C(C[C@@H](C(CC)=O)[C@@H]1OC)O[C@H](C)C[C@H](O2)[C@@H]2/C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]3[C@H](O)[C@@H](N(C)C)[C@@H]([C@@H](C)O3)O[C@@H]4O[C@H]([C@@H]([C@@](C)(C4)O)OC(CC)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 813.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Uyeda M, Mori S, Morita M, Ogata T, Mori M, Shibata M. Microbial transformation of antibiotics. III. Reacylation of 4"-depropionyl maridomycin III into maridomycin V (maridomycin K) by Streptomyces sp. strain no. K-342. J Antibiot (Tokyo). 1977 Dec;30(12):1130-1. PubMed PMID: 599088. 2: Harada S, Muroi M, Kondo M, Tsuchiya K, Matsuzawa T. Chemical modification of maridomycin, a new macrolide antibiotic. Antimicrob Agents Chemother. 1973 Aug;4(2):140-8. PubMed PMID: 4790934; PubMed Central PMCID: PMC444519. 3: Nakahama K, Izawa M, Muroi M, Kishi T, Uchida M. Microbial conversion of antibiotics. I. Deacylation of maridomycin by bacteria. J Antibiot (Tokyo). 1974 Jun;27(6):425-32. PubMed PMID: 4212166. 4: Muroi M, Izawa M, Ono H, Higashide E, Kishi T. Isolation of maridomycins and structure of maridomycin II. Experientia. 1972 May 15;28(5):501-2. PubMed PMID: 5040787. 5: Ono H, Hasegawa T, Higashide E, Shibata M. Maridomycin, a new macrolide antibiotic. I. Taxonomy and fermentation. J Antibiot (Tokyo). 1973 Apr;26(4):191-8. PubMed PMID: 4205650. 6: Muroi M, Izawa M, Kishi T. Maridomycin, a new macrolide antibiotic. XI. The structures of maridomycin components. Chem Pharm Bull (Tokyo). 1976 Mar;24(3):463-78. PubMed PMID: 1021252. 7: Kondo M, Ishifuji K, Tsuchiya K, Goto S, Kuwahara S. Maridomycin, a new macrolide antibiotic: in vivo antibacterial activity of 9-propionylmaridomycin. Antimicrob Agents Chemother. 1973 Aug;4(2):156-9. PubMed PMID: 4790936; PubMed Central PMCID: PMC444521. 8: Ono H, Harada S, Kishi T. Maridomycin, a new macrolide antibiotic. VII. Incorporation of labeled precursors into maridomycin and preparation of 14C-labeled 9-propionylmaridomycin. J Antibiot (Tokyo). 1974 Jun;27(6):442-8. PubMed PMID: 4853096. 9: Kondo K. Analytical studies of maridomycin. I. High-performance liquid chromatography of marido-mycins and some other macrolide antibiotics. J Chromatogr. 1979 Feb 1;169:329-36. PubMed PMID: 536423. 10: Muroi M, Izawa M, Kishi T. Maridomycin, a new macrolide antibiotic. X. The structure of maridomycin II. Chem Pharm Bull (Tokyo). 1976 Mar;24(3):450-62. PubMed PMID: 1021251. 11: Muroi M, Izawa M, Kishi T. Structures of maridomycin 1,3,4,5 and 6 macrolide antibiotics. Experientia. 1972 Feb 15;28(2):129-31. PubMed PMID: 5020329. 12: Nakahama K, Igarasi S. Microbial conversion of antibiotics. IV. Reduction of maridomycin. J Antibiot (Tokyo). 1974 Aug;27(8):605-9. PubMed PMID: 4436146. 13: Muroi M, Izawa M, Ono H, Higashide E, Kishi T. Isolation of maridomycins and structure of maridomycin II. Experientia. 1972 Aug 15;28(8):878-80. PubMed PMID: 5076309. 14: Kondo M, Oishi T, Tsuchiya K, Goto S, Kuwahara S. Maridomycin, a new macrolide antibiotic. In vitro antibacterial activity of 9-propionylmaridomycin. Antimicrob Agents Chemother. 1973 Aug;4(2):149-55. PubMed PMID: 4790935; PubMed Central PMCID: PMC444520. 15: Kunishige N, Kawamura K, Muroi M, Kishi T. Maridomycin, a new macrolide antibiotic. XII. A simple quantitative analysis of 9-propionylmaridomycin components. Chem Pharm Bull (Tokyo). 1975 Dec;23(12):3075-80. PubMed PMID: 1218448. 16: Nakahama K, Kishi T, Igarasi S. Microbial conversion of antibiotics. 3. Hydroxylation of maridomycin I and josamycin. J Antibiot (Tokyo). 1974 Jun;27(6):433-41. PubMed PMID: 4853208. 17: Nakahama K, Kishi T, Igarasi S. Letter: Microbial conversion of antibiotics. II. Deacylation of maridomycin by Actinomycetes. J Antibiot (Tokyo). 1974 Jun;27(6):487-8. PubMed PMID: 4852860. 18: Shibata M, Uyeda M, Mori S. I. Isolation and characterization of the transformation products of maridomycin III. J Antibiot (Tokyo). 1975 Jun;28(6):434-41. PubMed PMID: 1150539. 19: Shibata M, Uyeda M, Mori S. Microbial transformation of antibiotics II. Additional transformation products of maridomycin III. J Antibiot (Tokyo). 1976 Aug;29(8):824-8. PubMed PMID: 993121. 20: Uyeda M, Kubota K, Miyamura S, Shibata M. Microbial transformation of maridomycin III by Serratia marcescens. J Antibiot (Tokyo). 1983 Dec;36(12):1722-8. PubMed PMID: 6363373.

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