ß-Elemene | CAS#33880-83-0 | Pak1 inhibitor

MedKoo Cat#: 563477 | Name: ß-Elemene

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ß-Elemene is an inhibitor of Pak1 activation, and an anti-cancer ingredient isolated from the Chinese traditional herb Curcuma wenyujin.

Chemical Structure

ß-Elemene

CAS#33880-83-0

Theoretical Analysis

MedKoo Cat#: 563477

Name: ß-Elemene

CAS#: 33880-83-0

Chemical Formula: C15H24

Exact Mass: 204.1878

Molecular Weight: 204.35

Elemental Analysis: C, 88.16; H, 11.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

ß-Elemene; ß Elemene; beta Elemene; beta-Elemene;

IUPAC/Chemical Name

(1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl)cyclohexane

InChi Key

OPFTUNCRGUEPRZ-QLFBSQMISA-N

InChi Code

InChI=1S/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3/t13-,14+,15-/m1/s1

SMILES Code

C=C([C@H]1C[C@@H](C(C)=C)[C@](C)(C=C)CC1)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 204.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhou K, Wang L, Cheng R, Liu X, Mao S, Yan Y. Elemene Increases Autophagic Apoptosis and Drug Sensitivity in Human Cisplatin (DDP)-Resistant Lung Cancer Cell Line SPC-A-1/DDP By Inducing Beclin-1 Expression. Oncol Res. 2017 May 23. doi: 10.3727/096504017X14954936991990. [Epub ahead of print] PubMed PMID: 28550680. 2: Li J, Yu J, Liu A, Wang Y. Retraction notice to "ß-elemene against human lung cancer via up-regulation of P53 protein expression to promote the release of exosome": LUNG 86/2 (2014) 144-150. Lung Cancer. 2016 Jun;96:120. doi: 10.1016/j.lungcan.2016.03.003. PubMed PMID: 27133761. 3: Zhu T, Zhao Y, Zhang J, Li L, Zou L, Yao Y, Xu Y. ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6. Int J Oncol. 2011 Feb;38(2):419-26. doi: 10.3892/ijo.2010.855. Epub 2010 Dec 3. PubMed PMID: 21132268.