MedKoo Cat#: 563472 | Name: T6167923
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

T6167923 is an inhibitor of MyD88-dependent signaling pathways. It acts by disrupting MyD88 homodimeric formation, which is critical for its signaling function.

Chemical Structure

T6167923
T6167923
CAS#1090528-71-4

Theoretical Analysis

MedKoo Cat#: 563472

Name: T6167923

CAS#: 1090528-71-4

Chemical Formula: C17H20BrN3O3S2

Exact Mass: 457.0129

Molecular Weight: 458.38

Elemental Analysis: C, 44.54; H, 4.40; Br, 17.43; N, 9.17; O, 10.47; S, 13.99

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
T6167923; T-6167923; T 6167923;
IUPAC/Chemical Name
4-(3-Bromophenyl)sulfonyl-N-(1-thiophen-2-ylethyl)piperazine-1-carboxamide
InChi Key
PNTQVMBKHCOLQD-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20BrN3O3S2/c1-13(16-6-3-11-25-16)19-17(22)20-7-9-21(10-8-20)26(23,24)15-5-2-4-14(18)12-15/h2-6,11-13H,7-10H2,1H3,(H,19,22)
SMILES Code
O=C(N1CCN(S(=O)(C2=CC=CC(Br)=C2)=O)CC1)NC(C3=CC=CS3)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 458.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saqib U, Baig MS. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. 2018 Apr;29(4):295-318. doi: 10.1080/1062936X.2018.1431308. Epub 2018 Feb 15. PubMed PMID: 29448819. 2: Olson MA, Lee MS, Kissner TL, Alam S, Waugh DS, Saikh KU. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Sci Rep. 2015 Sep 18;5:14246. doi: 10.1038/srep14246. PubMed PMID: 26381092; PubMed Central PMCID: PMC4585646. 3: Xu Z, Cheng C, Zhang Y, Yang D, Jing W, Liu X, Li X. Lipopolysaccharide induces skin scarring through the TLR4/Myd88 inflammatory signaling pathway in dermal fibroblasts. Burns. 2023 Dec;49(8):1997-2006. doi: 10.1016/j.burns.2023.06.005. Epub 2023 Jun 16. PMID: 37821278.