IUPAC/Chemical Name
alpha-D-arabino-Hexopyranoside, methyl 3-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-2,3-dideoxy-
InChi Key
YQYBWJPESSJLTK-HXFLIBJXSA-N
InChi Code
InChI=1S/C10H18ClN3O6/c1-19-8-4-6(9(16)7(5-15)20-8)12-10(17)14(13-18)3-2-11/h6-9,15-16H,2-5H2,1H3,(H,12,17)/t6-,7-,8+,9+/m1/s1
SMILES Code
CO[C@@H]1C[C@H]([C@@H]([C@H](O1)CO)O)NC(N(N=O)CCCl)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
311.72
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: el Abed I, Roger P, Gosse C, Atassi G, Gouyette A. Chemical stability of ecomustine, a new antitumor agent in aqueous and biological media as assessed by high-performance liquid chromatography. Cancer Chemother Pharmacol. 1991;27(4):295-300. PubMed PMID: 1998985.
2: Dumont P, Atassi G, Roger P. Evaluation of a new nitrosoureido water-soluble sugar, ecomustine or CY 233 (NSC 609224), on human xenografts. In Vivo. 1990 Jan-Feb;4(1):61-4. PubMed PMID: 2103843.
3: Gosse C, Atassi G, Letourneux Y, Ardouin P, Gouyette A, Fournier JP, Roger P. Antitumour activity of a new water-soluble nitrosoureido sugar: CY233 (NSC 609224). Anticancer Res. 1988 Nov-Dec;8(6):1419-22. PubMed PMID: 3218975.
4: Atassi G, Dumont P, Gosse C, Fournier JP, Gouyette A, Roger P. Characterization of the anti-tumour activity against solid tumours of a new nitrosoureido sugar: Cy 233. Cancer Chemother Pharmacol. 1989;25(3):205-9. PubMed PMID: 2598412.
