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MedKoo Cat#: 563466 | Name: 6bK

Description:

WARNING: This product is for research use only, not for human or veterinary use.

6bK is an insulin degrading enzyme (IDE) inhibitor.

Chemical Structure

6bK
6bK
CAS#1774353-12-6

Theoretical Analysis

MedKoo Cat#: 563466

Name: 6bK

CAS#: 1774353-12-6

Chemical Formula: C41H55N7O7

Exact Mass: 757.4163

Molecular Weight: 757.93

Elemental Analysis: C, 64.97; H, 7.31; N, 12.94; O, 14.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
6bK; 6-bK; 6 bK; IDE-IN-6bK; IDE inhibitor 6bK; IDE-inhibitor-6bK;
IUPAC/Chemical Name
(3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
InChi Key
BHZABWWULWHRIY-JAXGQCOVSA-N
InChi Code
InChI=1S/C41H55N7O7/c42-23-9-7-16-32-40(54)48-34(25-27-11-3-1-4-12-27)41(55)47-33(26-28-17-19-30(20-18-28)37(51)29-13-5-2-6-14-29)39(53)44-24-10-8-15-31(38(43)52)45-35(49)21-22-36(50)46-32/h2,5-6,13-14,17-22,27,31-34H,1,3-4,7-12,15-16,23-26,42H2,(H2,43,52)(H,44,53)(H,45,49)(H,46,50)(H,47,55)(H,48,54)/b22-21+/t31-,32-,33+,34-/m0/s1
SMILES Code
O=C([C@H]1NC(/C=C/C(N[C@@H](CCCCN)C(N[C@@H](CC2CCCCC2)C(N[C@H](CC3=CC=C(C(C4=CC=CC=C4)=O)C=C3)C(NCCCC1)=O)=O)=O)=O)=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 757.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hahn F, Schmalen A, Setz C, Friedrich M, Schlößer S, Kölle J, Spranger R, Rauch P, Fraedrich K, Reif T, Karius-Fischer J, Balasubramanyam A, Henklein P, Fossen T, Schubert U. Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. PLoS One. 2017 Apr 7;12(4):e0174254. doi: 10.1371/journal.pone.0174254. eCollection 2017. PubMed PMID: 28388673; PubMed Central PMCID: PMC5384750. 2: Bhattacharyya MR, Perkins-Porras L, Whitehead DL, Steptoe A. Psychological and clinical predictors of return to work after acute coronary syndrome. Eur Heart J. 2007 Jan;28(2):160-5. Epub 2006 Dec 21. PubMed PMID: 17185305.