Synonym
Cianergoline; Cianergolinum
IUPAC/Chemical Name
(alpha-RS)-alpha-Cyano-6-methylergoline-8beta-propionamide
InChi Key
LVMVXZOPCAMYHC-QOAXCGLXSA-N
InChi Code
InChI=1S/C19H22N4O/c1-23-10-11(5-12(8-20)19(21)24)6-15-14-3-2-4-16-18(14)13(9-22-16)7-17(15)23/h2-4,9,11-12,15,17,22H,5-7,10H2,1H3,(H2,21,24)/t11-,12?,15-,17-/m1/s1
SMILES Code
[H][C@@]1(N(C)C[C@H](CC(C#N)C(N)=O)C[C@@]12[H])CC3=CNC4=C3C2=CC=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
322.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Potter DE, Shumate DJ. Cianergoline lowers intraocular pressure in rabbits and monkeys and inhibits contraction of the cat nictitans by suppressing sympathetic neuronal function. J Ocul Pharmacol. 1987 Winter;3(4):309-21. PubMed PMID: 3503920.
2: Bise G, Foletti C, Beretta-Piccoli C, Weidmann P, Ziegler WH, Mordasini R, Bachmann C. Effects of the dopaminergic agonist cianergoline on blood pressure, the renin-angiotensin-aldosterone axis and the sympathetic nervous system in patients with essential hypertension. Eur J Clin Pharmacol. 1985;29(1):25-31. PubMed PMID: 4054204.
3: Ohno S, Koumori M, Adachi Y, Mizukoshi K, Nagasaka M, Ichihara K. Synthesis and structure-activity relationships of new (5R,8S,10R)-ergoline derivatives with antihypertensive or dopaminergic activity. Chem Pharm Bull (Tokyo). 1994 Oct;42(10):2042-8. PubMed PMID: 7805128.
4: Salvati P, Caravaggi AM, Lamberti E, Monteggia M, Bianchi G. Cardiovascular effects of a new antihypertensive agent in several species. Arzneimittelforschung. 1983;33(8):1098-106. PubMed PMID: 6685486.
5: Salvati P, Bianchi G. Involvement of peripheral dopamine receptors in the antihypertensive effect of a new ergoline derivative (355/1057). Arch Int Pharmacodyn Ther. 1985 Apr;274(2):291-304. PubMed PMID: 4026460.
