MedKoo Cat#: 598640 | Name: Leucinostatin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucinostatin B is a peptide antibiotic isolated from Paecilomyces lilacinus A-267.

Chemical Structure

Leucinostatin B
Leucinostatin B
CAS#76663-52-0

Theoretical Analysis

MedKoo Cat#: 598640

Name: Leucinostatin B

CAS#: 76663-52-0

Chemical Formula: C61H109N11O13

Exact Mass: 1203.8206

Molecular Weight: 1204.60

Elemental Analysis: C, 60.82; H, 9.12; N, 12.79; O, 17.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Leucinostatin B; Paecilotoxin B;
IUPAC/Chemical Name
(2S,4S)-N-((4S,17S,20S,26S,29R,31S,33S)-33-hydroxy-26-((R)-1-hydroxy-2-methylpropyl)-17,20-diisobutyl-4,11,11,14,14,23,23,31-octamethyl-6,10,13,16,19,22,25,28,35-nonaoxo-2,5,9,12,15,18,21,24,27-nonaazaheptatriacontan-29-yl)-4-methyl-1-((R,E)-4-methylhex-2-enoyl)pyrrolidine-2-carboxamide
InChi Key
JLDCSWRYRVBFRU-YHHRVAAASA-N
InChi Code
InChI=1S/C61H109N11O13/c1-20-37(9)22-23-48(76)72-33-39(11)30-46(72)54(81)66-45(29-38(10)28-42(74)31-41(73)21-2)52(79)68-49(50(77)36(7)8)55(82)70-60(15,16)57(84)67-43(26-34(3)4)51(78)65-44(27-35(5)6)53(80)69-61(17,18)58(85)71-59(13,14)56(83)63-25-24-47(75)64-40(12)32-62-19/h22-23,34-40,42-46,49-50,62,74,77H,20-21,24-33H2,1-19H3,(H,63,83)(H,64,75)(H,65,78)(H,66,81)(H,67,84)(H,68,79)(H,69,80)(H,70,82)(H,71,85)/b23-22+/t37-,38-,39+,40+,42+,43+,44+,45-,46+,49+,50-/m1/s1
SMILES Code
CNC[C@H](C)NC(CCNC(C(C)(C)NC(C(C)(C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C(C)(C)NC([C@H]([C@H](O)C(C)C)NC([C@H](NC([C@@H]1C[C@H](C)CN1C(/C=C/[C@H](C)CC)=O)=O)C[C@H](C)C[C@H](O)CC(CC)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,204.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mori Y, Suzuki M, Fukushima K, Arai T. Structure of leucinostatin B, an uncoupler on mitochondria. J Antibiot (Tokyo). 1983 Aug;36(8):1084-6. PubMed PMID: 6630061. 2: Ishiyama A, Otoguro K, Iwatsuki M, Namatame M, Nishihara A, Nonaka K, Kinoshita Y, Takahashi Y, Masuma R, Shiomi K, Yamada H, Omura S. In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin. J Antibiot (Tokyo). 2009 Jun;62(6):303-8. doi: 10.1038/ja.2009.32. Epub 2009 May 1. Erratum in: J Antibiot (Tokyo). 2009 Jun;62(6):343. Iwatsuki, Masahito [corrected to Iwatsuki, Masato]. PubMed PMID: 19407848. 3: Fukushima K, Arai T, Mori Y, Tsuboi M, Suzuki M. Studies on peptide antibiotics, leucinostatins. I. Separation, physico-chemical properties and biological activities of leucinostatins A and B. J Antibiot (Tokyo). 1983 Dec;36(12):1606-12. PubMed PMID: 6662804. 4: Fukushima K, Arai T, Mori Y, Tsuboi M, Suzuki M. Studies on peptide antibiotics, leucinostatins. II. The structures of leucinostatins A and B. J Antibiot (Tokyo). 1983 Dec;36(12):1613-30. PubMed PMID: 6662805. 5: Mikami Y, Fukushima K, Arai T, Abe F, Shibuya H, Ommura Y. Leucinostatins, peptide mycotoxins produced by Paecilomyces lilacinus and their possible roles in fungal infection. Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Jul;257(2):275-83. PubMed PMID: 6485630. 6: Mikami Y, Yazawa K, Fukushima K, Arai T, Udagawa S, Samson RA. Paecilotoxin production in clinical or terrestrial isolates of Paecilomyces lilacinus strains. Mycopathologia. 1989 Dec;108(3):195-9. PubMed PMID: 2615806. 7: Shima A, Fukushima K, Arai T, Terada H. Dual inhibitory effects of the peptide antibiotics leucinostatins on oxidative phosphorylation in mitochondria. Cell Struct Funct. 1990 Feb;15(1):53-8. PubMed PMID: 2140298.