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MedKoo Cat#: 598632 | Name: Leucanicidin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucanicidin is a macrolide bacterial metabolite originally isolated from S. halstedii. It is toxic to L. separata fourth instar larvae when used at a concentration of 20 ppm and to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s = 0.23-0.42 µg/ml).

Chemical Structure

Leucanicidin
Leucanicidin
CAS#91021-66-8

Theoretical Analysis

MedKoo Cat#: 598632

Name: Leucanicidin

CAS#: 91021-66-8

Chemical Formula: C42H70O13

Exact Mass: 782.4816

Molecular Weight: 783.00

Elemental Analysis: C, 64.43; H, 9.01; O, 26.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Leucanicidin;
IUPAC/Chemical Name
(3Z,5Z,7R,8S,9S,11Z,13E,15R,16R)-16-((2S,3R,4R)-4-((2R,4R,5R,6R)-4-(((2R,3R,4S,5R,6S)-4,5-dihydroxy-3-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-hydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
InChi Key
KFLYTTUTONVURR-BSTYEBPJSA-N
InChi Code
InChI=1S/C42H70O13/c1-21(2)37-26(7)32(53-41-39(51-13)36(46)35(45)29(10)52-41)20-42(48,55-37)28(9)34(44)27(8)38-30(49-11)16-14-15-22(3)17-24(5)33(43)25(6)18-23(4)19-31(50-12)40(47)54-38/h14-16,18-19,21,24-30,32-39,41,43-46,48H,17,20H2,1-13H3/b16-14+,22-15-,23-18-,31-19-/t24-,25+,26+,27-,28+,29-,30+,32+,33-,34+,35-,36-,37+,38+,39+,41-,42+/m0/s1
SMILES Code
C[C@@H]1O[C@@H](O[C@@H]2C[C@@]([C@H](C)[C@H](O)[C@H](C)[C@@H]3[C@H](OC)/C=C/C=C(C)\C[C@H](C)[C@H](O)[C@H](C)/C=C(\C=C(OC)\C(O3)=O)C)(O)O[C@H](C(C)C)[C@@H]2C)[C@H](OC)[C@@H](O)[C@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 783.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu C, Medema MH, Läkamp RM, Zhang L, Dorrestein PC, Choi YH, van Wezel GP. Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes in Kitasatospora sp. MBT66. ACS Chem Biol. 2016 Feb 19;11(2):478-90. doi: 10.1021/acschembio.5b00801. Epub 2015 Dec 24. PubMed PMID: 26675041. 2: Lacey E, Gill JH, Power ML, Rickards RW, O'Shea MG, Rothschild JM. Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes. Int J Parasitol. 1995 Mar;25(3):349-57. PubMed PMID: 7601593. 3: O'Shea MG, Rickards RW, Rothschild JM, Lacey E. Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups. J Antibiot (Tokyo). 1997 Dec;50(12):1073-7. PubMed PMID: 9510919.