Letrazuril | CAS#103337-74-2 | antiprotozoal

MedKoo Cat#: 598623 | Name: Letrazuril

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Letrazuril is an antiprotozoal effective against Cryptosporidium infections.

Chemical Structure

Letrazuril

CAS#103337-74-2

Theoretical Analysis

MedKoo Cat#: 598623

Name: Letrazuril

CAS#: 103337-74-2

Chemical Formula: C17H9Cl2FN4O2

Exact Mass: 390.0087

Molecular Weight: 391.18

Elemental Analysis: C, 52.20; H, 2.32; Cl, 18.12; F, 4.86; N, 14.32; O, 8.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Letrazuril; Letrazurilum; Letrazurilo;

IUPAC/Chemical Name

2-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenyl)-2-(4-fluorophenyl)acetonitrile

InChi Key

XQKYUBTUOHHNDV-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H9Cl2FN4O2/c18-13-5-11(24-17(26)23-15(25)8-22-24)6-14(19)16(13)12(7-21)9-1-3-10(20)4-2-9/h1-6,8,12H,(H,23,25,26)

SMILES Code

N#CC(C1=C(Cl)C=C(N2C(NC(C=N2)=O)=O)C=C1Cl)C3=CC=C(F)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 391.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hamour AA, Bonnington A, Hawthorne B, Wilkins EG. Successful treatment of AIDS-related cryptosporidial sclerosing cholangitis. AIDS. 1993 Nov;7(11):1449-51. PubMed PMID: 8280410. 2: Harris M, Deutsch G, MacLean JD, Tsoukas CM. A phase I study of letrazuril in AIDS-related cryptosporidiosis. AIDS. 1994 Aug;8(8):1109-13. PubMed PMID: 7986407. 3: Loeb M, Walach C, Phillips J, Fong I, Salit I, Rachlis A, Walmsley S. Treatment with letrazuril of refractory cryptosporidial diarrhea complicating AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Sep 1;10(1):48-53. PubMed PMID: 7648284. 4: Murdoch DA, Bloss DE, Glover SC. Successful treatment of cryptosporidiosis in an AIDS patient with letrazuril. AIDS. 1993 Sep;7(9):1279-80. PubMed PMID: 8216993. 5: Victor GH, Conway B, Hawley-Foss NC, Manion D, Sahai J. Letrazuril therapy for cryptosporidiosis: clinical response and pharmacokinetics. AIDS. 1993 Mar;7(3):438-40. PubMed PMID: 8471212. 6: Blanshard C, Shanson DC, Gazzard BG. Pilot studies of azithromycin, letrazuril and paromomycin in the treatment of cryptosporidiosis. Int J STD AIDS. 1997 Feb;8(2):124-9. PubMed PMID: 9061412.