Synonym
Gebyl; Metochalcone; NSC 97905; NSC-97905; NSC97905; Vesidril;
IUPAC/Chemical Name
(E)-1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
InChi Key
HVAKUYCEWDPRCA-IZZDOVSWSA-N
InChi Code
InChI=1S/C18H18O4/c1-20-14-7-4-13(5-8-14)6-11-17(19)16-10-9-15(21-2)12-18(16)22-3/h4-12H,1-3H3/b11-6+
SMILES Code
O=C(C1=CC=C(OC)C=C1OC)/C=C/C2=CC=C(OC)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
298.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Salum LB, Altei WF, Chiaradia LD, Cordeiro MN, Canevarolo RR, Melo CP, Winter E, Mattei B, Daghestani HN, Santos-Silva MC, Creczynski-Pasa TB, Yunes RA, Yunes JA, Andricopulo AD, Day BW, Nunes RJ, Vogt A. Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors. Eur J Med Chem. 2013 May;63:501-10. doi: 10.1016/j.ejmech.2013.02.037. Epub 2013 Mar 6. PubMed PMID: 23524161; PubMed Central PMCID: PMC3674157.
2: Lai CH, Rao YK, Fang SH, Sing YT, Tzeng YM. Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5462-5. doi: 10.1016/j.bmcl.2010.07.094. Epub 2010 Jul 25. PubMed PMID: 20705463.
3: Rao MS, Narukulla R. A new trimethoxychalcone from Crotalaria ramosissima. Fitoterapia. 2007 Sep;78(6):446-7. Epub 2007 Apr 11. PubMed PMID: 17616261.
4: FELIX H. [1314 CB, synthetic choleretic; therapeutic trial]. Alger Medicale. 1958 Jun;62(6):611-4 passim. French. PubMed PMID: 13571107.
5: CACHIN M, PERGOLA F, VONTHRON A. [Contribution to the study of a new synthetic choleretic: 4,2',4'-trimethoxychalcone]. Concours Med. 1959 Dec 5;81:5349-52. French. PubMed PMID: 13806727.
6: CARDINI C, VENEZIANI C, CALO A. [Analytic research on 4,2',4'-trimethoxychalcone]. Rend Ist Sup Sanit. 1961;24:741-7. Italian. PubMed PMID: 13876513.
7: BRUNAUD M, BRUNAUD S, SEGAL V. [Research on the properties of 2', 4, 4'-trimethoxychalcone. I. Toxicity]. Therapie. 1958;13(4):668-75. French. PubMed PMID: 13603405.
8: DIOGUARDI N, COSTA F. [Considerations on the use of a non-cholecystokinetic choleretic, 4, 2', 4'-trimethoxychalcone, in patients with cholelithiasis]. Minerva Med. 1962 Oct 17;53:3090-4. Italian. PubMed PMID: 14027995.
9: SCHWARTZ R. [Choleresis & choleretics; clinical trial of 1314 CB]. Gaz Med Fr. 1958 Sep 25;65(18):1473-6. English, French. PubMed PMID: 13586567.
