Synonym
Riodipine; Foridon; PP-1466;
IUPAC/Chemical Name
dimethyl 4-(2-(difluoromethoxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
InChi Key
AZVFIZVKGSPGPK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19F2NO5/c1-9-13(16(22)24-3)15(14(10(2)21-9)17(23)25-4)11-7-5-6-8-12(11)26-18(19)20/h5-8,15,18,21H,1-4H3
SMILES Code
O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2OC(F)F)OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
367.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zherelova OM, Grishchenko VM, Chaylakhyan LM. Blockers of Ca2+ channels in the plasmalemma of perfused Characeae cells. Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Mar;107(3):475-80. PubMed PMID: 8061954.
2: Kryzhanovskiĭ GN, Karpova MN, Abrosimov IIu. [The anticonvulsive activity of the 1,4-dihydropyridine derivative riodipine and other anticonvulsants when used in combination]. Biull Eksp Biol Med. 1993 Jul;116(7):15-7. Russian. PubMed PMID: 8400164.
3: Kryzhanovskiĭ GN, Karpova MN, Pankov OIu, Abramova EM, Abrosimov IIu. [The antiepileptic effects of sodium valproate and the calcium antagonist riodipine when used jointly in a model of generalized korazol-induced epileptic activity]. Biull Eksp Biol Med. 1992 Oct;114(10):376-8. Russian. PubMed PMID: 1288691.
4: Kryzhanovskiĭ GN, Karpova MN, Abramova EM, Abrosimov IIu. [The antiepileptic effects of sodium valproate and the calcium antagonist riodipine when used jointly in a model of focal penicillin-induced epileptic activity]. Biull Eksp Biol Med. 1992 Oct;114(10):369-70. Russian. PubMed PMID: 1288688.
5: Tirzite DIa, Tirzit GD, Dubur GIa. [Effects of nifedipine and riodipine on biochemical processes in intact erythrocytes]. Biull Eksp Biol Med. 1990 Oct;110(10):379-81. Russian. PubMed PMID: 2279087.
6: Dudkin SM, Polev PV, Soldatov NM. Calcium entry blockers and oxiracetam have opposite effects on the density of dihydropyridine receptors in rat cerebral cortex. Brain Res. 1990 Aug 20;525(2):319-21. PubMed PMID: 2174714.
7: Simkhovich BZ, Meĭrena DV, Khagi KhB, Shutenko ZhV, Mezhapuke RIa. [Effect of the calcium antagonists ryodipine and verapamil on the carnitine-dependent metabolism of fatty acids in the rat heart]. Farmakol Toksikol. 1989 Jan-Feb;52(1):34-7. Russian. PubMed PMID: 2707416.
8: Soldatov NM. [Solubilization and isolation of dihydropyridine calcium channel blocker receptor from the rabbit skeletal muscle]. Biokhimiia. 1988 Sep;53(9):1418-26. Russian. PubMed PMID: 2849480.
