Bifidenone | 2078008-57-6 | Tubulin Polymerization Inhibitor

MedKoo Cat#: 330146 | Name: Bifidenone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bifidenone is a potent Tubulin Polymerization Inhibitor.

Chemical Structure

Bifidenone

CAS#2078008-57-6

Theoretical Analysis

MedKoo Cat#: 330146

Name: Bifidenone

CAS#: 2078008-57-6

Chemical Formula: C21H26O5

Exact Mass: 358.1780

Molecular Weight: 358.43

Elemental Analysis: C, 70.37; H, 7.31; O, 22.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

(+)-Bifidenone; Bifidenone

IUPAC/Chemical Name

(6S,7aR)-6-allyl-7a-((S)-1-(3,4-dimethoxyphenyl)propan-2-yl)-7,7a-dihydrobenzo[d][1,3]dioxol-5(6H)-one

InChi Key

BHTLRQBVGVBCSE-WDUKFBBWSA-N

InChi Code

InChI=1S/C21H26O5/c1-5-6-16-12-21(20(11-17(16)22)25-13-26-21)14(2)9-15-7-8-18(23-3)19(10-15)24-4/h5,7-8,10-11,14,16H,1,6,9,12-13H2,2-4H3/t14-,16-,21+/m0/s1

SMILES Code

O=C1C=C2OCO[C@@]2([C@@H](C)CC3=CC=C(OC)C(OC)=C3)C[C@@H]1CC=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 358.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang Z, Williams RB, Martin SM, Lawrence JA, Norman VL, O'Neil-Johnson M, Harding J, Mangette JE, Liu S, Guzzo P, Starks CM, Eldridge GR. Bifidenone: Structure-Activity Relationship and Advanced Preclinical Candidate. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.7b01644. [Epub ahead of print] PubMed PMID: 29995409. 2: Huang Z, Williams RB, O'Neil-Johnson M, Eldridge GR, Mangette JE, Starks CM. A Total Synthesis of Bifidenone. J Org Chem. 2017 Apr 21;82(8):4235-4241. doi: 10.1021/acs.joc.7b00202. Epub 2017 Mar 31. PubMed PMID: 28351141. 3: Williams RB, Martin SM, Lawrence JA, Norman VL, O'Neil-Johnson M, Eldridge GR, Starks CM. Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone. J Nat Prod. 2017 Mar 24;80(3):616-624. doi: 10.1021/acs.jnatprod.6b00893. Epub 2016 Nov 14. PubMed PMID: 28335606.