Synonym
Nifurzide; Ricridene;
IUPAC/Chemical Name
5-nitro-N'-((1E,2E)-3-(5-nitrofuran-2-yl)allylidene)thiophene-2-carbohydrazide
InChi Key
IDUMOVRJNBNOTR-BIZLIJPVSA-N
InChi Code
InChI=1S/C12H8N4O6S/c17-12(9-4-6-11(23-9)16(20)21)14-13-7-1-2-8-3-5-10(22-8)15(18)19/h1-7H,(H,14,17)/b2-1+,13-7+
SMILES Code
O=C(C1=CC=C([N+]([O-])=O)S1)N/N=C/C=C/C2=CC=C([N+]([O-])=O)O2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
336.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Labaune JP, Moreau JP, Byrne R. Comparative physiological disposition of two nitrofuran anti-microbial agents. Biopharm Drug Dispos. 1986 Sep-Oct;7(5):431-41. PubMed PMID: 3779034.
3: Leonard F, Andremont A, Tancrede C. In vivo activity of nifurzide and nifuroxazide in intestinal bacteria in man and gnotobiotic mice. J Appl Bacteriol. 1985 Jun;58(6):545-53. PubMed PMID: 4030525.
4: Darfeuille-Michaud A, Forestier C, Rich C, Wash E, Joly B, Cluzel R. [Inhibition by nifurzide of the adhesion capacity of enteropathogenic colibacillus to HEP-2 cells]. Pathol Biol (Paris). 1989 Dec;37(10):1090-3. French. PubMed PMID: 2691964.
5: Gavinet AM, Mégraud F. [Study of the sensitivity of enteropathogenic bacteria to nifurzide]. Pathol Biol (Paris). 1987 May;35(5):542-4. French. PubMed PMID: 3302859.
6: Videz S, Perrier J, Gounot AM. [Study of the mechanisms of action on the bacterial cell of a new antimicrobial drug: nifurzide (author's transl)]. Ann Pharm Fr. 1981;39(5):451-62. French. PubMed PMID: 7034623.
7: Michel-Briand Y, Laporte JM. Inhibition of conjugal transfer of R plasmids by nitrofurans. J Gen Microbiol. 1985 Sep;131(9):2281-4. PubMed PMID: 3906037.
8: Michel-Briand Y, Laporte JM. [Inhibition of the diffusion of plasmids by a nitrofuran derivative]. C R Seances Acad Sci III. 1982 Feb 1;294(5):249-52. French. PubMed PMID: 6804030.
9: Michel-Briand Y, Laporte JM, Couetdic G, Sansonetti PJ. Elimination of a virulence plasmid from Shigella sonnei and Escherichia coli by antibiotics. Ann Inst Pasteur Microbiol. 1986 Nov-Dec;137B(3):291-5. PubMed PMID: 3318870.
10: Michel-Briand Y, Laporte JM, Plesiat P, Sansonetti PJ. [The role of 4-quinolones and antibiotics in the elimination of virulence plasmids of Enterobacteriaceae]. Pathol Biol (Paris). 1987 Dec;35(10 Pt 2):1386-8. French. PubMed PMID: 3325901.
11: Basly JP, Basly I, Bernard M. Electron spin resonance detection of radiosterilization of pharmaceuticals: application to four nitrofurans. Analyst. 1998 Aug;123(8):1753-6. PubMed PMID: 10071389.
