Synonym
Ribalinine; (S)-Ribalinine;
IUPAC/Chemical Name
3-hydroxy-2,2,10-trimethyl-2,3,4,10-tetrahydro-5H-pyrano[2,3-b]quinolin-5-one
InChi Key
HUPKGVIVTBASQC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H17NO3/c1-15(2)12(17)8-10-13(18)9-6-4-5-7-11(9)16(3)14(10)19-15/h4-7,12,17H,8H2,1-3H3
SMILES Code
O=C1C(CC(O)C(C)(C)O2)=C2N(C)C3=C1C=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
259.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Corral RA, Orazi OO. Isolation, structure and synthesis of (+-)-ribalinine. Tetrahedron Lett. 1967 Feb;7:583-5. PubMed PMID: 6044205.
2: Gaillard E, Muyard F, Bevalot F, Regnier A, Vaquette J. [Rutacea from New Caledonia. Chemical composition of stem bark of Citrus macroptera Montr]. Ann Pharm Fr. 1995;53(2):75-8. French. PubMed PMID: 7762944.
3: Sultana N, Khalid A. A new fatty ester and a new triterpene from Skimmia laureola. Nat Prod Res. 2008 Jan 10;22(1):37-47. PubMed PMID: 17999337.
4: Puricelli L, Innocenti G, Delle Monache G, Caniato R, Filippini R, Cappelletti EM. In vivo and in vitro production of alkaloids by Haplophyllum patavinum. Nat Prod Lett. 2002 Apr;16(2):95-100. PubMed PMID: 11990434.
5: Atta-ur-Rahman, Khalid A, Sultana N, Ghayur MN, Mesaik MA, Khan MR, Gilani AH, Choudhary MI. New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. J Enzyme Inhib Med Chem. 2006 Dec;21(6):703-10. PubMed PMID: 17252943.
6: Aktar K, Foyzun T. Phytochemistry and Pharmacological Studies of Citrus macroptera: A Medicinal Plant Review. Evid Based Complement Alternat Med. 2017;2017:9789802. doi: 10.1155/2017/9789802. Epub 2017 Jun 27. Review. PubMed PMID: 28740540; PubMed Central PMCID: PMC5504973.
