MedKoo Cat#: 592610 | Name: Isoaminile citrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoaminile citrate is an Antitussive agent.

Chemical Structure

 Isoaminile citrate
Isoaminile citrate
CAS#28416-66-2

Theoretical Analysis

MedKoo Cat#: 592610

Name: Isoaminile citrate

CAS#: 28416-66-2

Chemical Formula: C22H32N2O7

Exact Mass: 436.2210

Molecular Weight: 436.51

Elemental Analysis: C, 60.54; H, 7.39; N, 6.42; O, 25.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
IUPAC/Chemical Name
(3-Cyano-2-methyl-3-phenylhexane-5-yl)dimethylammonium dihydrogen (2-hydroxypropane-1,2,3-tricarboxylate)
InChi Key
ZXASMEUEMIIBDZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N2.C6H8O7/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15;7-3(8)1-6(13,5(11)12)2-4(9)10/h6-10,13-14H,11H2,1-5H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES Code
C[NH+](C(C)CC(C1=CC=CC=C1)(C#N)C(C)C)C.O=C(CC(C(O)=O)(O)CC([O-])=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 436.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Diwan J, Dhand R, Jindal SK, Malik SK, Sharma PL. A comparative randomized double-blind clinical trial of isoaminile citrate and chlophedianol hydrochloride as antitussive agents. Int J Clin Pharmacol Ther Toxicol. 1982 Aug;20(8):373-5. PubMed PMID: 6749701. 2: GRAHAM JD. Evaluation of isoaminile citrate as an antitussive. J New Drugs. 1962 Jan-Feb;2:43-9. PubMed PMID: 13901029. 3: Isoaminile citrate as a cough suppressant. Practitioner. 1966 Mar;196(173):436-8. PubMed PMID: 5905421. 4: Marigo M, Ferrara SD, Cima L, Giusti P, Floreani M. Some cases of acute intoxications from compulsive use of isoaminile. Arch Toxicol. 1979 Sep;42(4):295-301. PubMed PMID: 518294. 5: Iffland R. [Drug abuse of isoaminile]. Z Rechtsmed. 1973 Apr 30;72(2):124-7. German. PubMed PMID: 4733605. 6: Bastos WP, Ramos AO. Isoaminile as inhibitor of muscarinic and nicotinic ganglionic receptors. Pharmacology. 1970;4(1):39-44. PubMed PMID: 5431771. 7: ZEHBE I. [Experiences with the cough medication peracon]. Medizinische. 1958 Sep;36(6):1401-2. German. PubMed PMID: 13589509. 8: PETERSEN MT. [2 Years of experience with peracon in general practice]. Dtsch Med J. 1960 May 5;11:235-6. German. PubMed PMID: 14432226. 9: SCHULZE KH. [Further clinical experiences with peracon and peracon expectorant]. Ther Ggw. 1961 Nov;100:579-80. German. PubMed PMID: 13909558. 10: BRENNER-GOEDDERZ L. [Peracon in practice. Experiences with a new kind of antitussive agent]. Med Klin. 1959 Oct 30;54:2004-6. German. PubMed PMID: 13804201. 11: Euler HH, Kleine L, Gutschmidt HJ, Herrlinger JD. [Goodpasture's syndrome--rapid remission after early plasmapheresis and high-dose cyclophosphamide therapy (author's transl)]. Klin Wochenschr. 1982 Jun 15;60(12):635-6. German. PubMed PMID: 7109502. 12: BRAEUNLICH H. [ON THE MORPHINE-LIKE PROPERTIES OF A NEW ANTITUSSIVE (ISOAMINIL; PERACON, MULLATUSS)]. Pharmazie. 1964 Oct;19:650-4. German. PubMed PMID: 14345464. 13: SCHMIEDEL R. [Clinical comparison of a new antitussive substance (peracon) with codeine & dicodide]. Ther Ggw. 1959 May;98(5):239-40. German. PubMed PMID: 13676089. 14: Althaus W, Funke S, Krause D, Rosskopf F, Stühmer W. [Metabolism of isoaminiles]. Dtsch Tierarztl Wochenschr. 1966 May 15;73(10):222-8. German. PubMed PMID: 5966751.