MedKoo Cat#: 461297 | Name: Flordipine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flordipine is a calcium channel blocker.

Chemical Structure

Flordipine
Flordipine
CAS#77590-96-6

Theoretical Analysis

MedKoo Cat#: 461297

Name: Flordipine

CAS#: 77590-96-6

Chemical Formula: C26H33F3N2O5

Exact Mass: 510.2342

Molecular Weight: 510.55

Elemental Analysis: C, 61.17; H, 6.52; F, 11.16; N, 5.49; O, 15.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Flordipine; RHC 2906; RHC-2906; RHC2906;
IUPAC/Chemical Name
diethyl 2,6-dimethyl-1-(2-morpholinoethyl)-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChi Key
RSXGUJLKWYUPMC-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H33F3N2O5/c1-5-35-24(32)21-17(3)31(12-11-30-13-15-34-16-14-30)18(4)22(25(33)36-6-2)23(21)19-9-7-8-10-20(19)26(27,28)29/h7-10,23H,5-6,11-16H2,1-4H3
SMILES Code
O=C(C1=C(C)N(CCN2CCOCC2)C(C)=C(C(OCC)=O)C1C3=CC=CC=C3C(F)(F)F)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 510.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mayhan WG, Heistad DD. Effect of flordipine on cerebral blood flow. J Pharmacol Exp Ther. 1985 Oct;235(1):92-7. PubMed PMID: 4045730. 2: Gordon EH, Wong SC, Klaustermeyer WB. Comparison of nifedipine with a new calcium channel blocker, flordipine, in exercise-induced asthma. J Asthma. 1987;24(5):261-5. PubMed PMID: 3327854. 3: Kritchevsky D, Tepper SA, Klurfeld DM. Flordipine, a calcium channel blocker, which does not influence lipidemia or atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 1988 Jan;69(1):89-92. PubMed PMID: 3355610. 4: Rosenberg M, Choi RL. High-performance liquid chromatographic analysis of flordipine in human plasma. J Chromatogr. 1984 Jun 8;308:382-6. PubMed PMID: 6746831. 5: Klunk LJ, Mangat S. Gas chromatographic assay for the quantitation of flordipine in human plasma. J Chromatogr. 1986 Dec 19;383(2):405-11. PubMed PMID: 3558570. 6: Helland LA, Lopez JR, Taylor SR, Trube G, Wanek LA. Effects of calcium "antagonists" on vertebrate skeletal muscle cells. Ann N Y Acad Sci. 1988;522:259-68. PubMed PMID: 3259850.