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MedKoo Cat#: 461286 | Name: Halofenozide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Halofenozide is a non-steroidal ecdysone agonist. It is used as a potent insecticide.

Chemical Structure

Halofenozide
Halofenozide
CAS#112226-61-6

Theoretical Analysis

MedKoo Cat#: 461286

Name: Halofenozide

CAS#: 112226-61-6

Chemical Formula: C18H19ClN2O2

Exact Mass: 330.1135

Molecular Weight: 330.81

Elemental Analysis: C, 65.35; H, 5.79; Cl, 10.72; N, 8.47; O, 9.67

Price and Availability

Size Price Availability Quantity
25mg USD 685.00 2 Weeks
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Related CAS #
No Data
Synonym
Halofenozide; RH 0345; RH-0345; RH0345;
IUPAC/Chemical Name
N'-benzoyl-N'-(tert-butyl)-4-chlorobenzohydrazide
InChi Key
CNKHSLKYRMDDNQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19ClN2O2/c1-18(2,3)21(17(23)14-7-5-4-6-8-14)20-16(22)13-9-11-15(19)12-10-13/h4-12H,1-3H3,(H,20,22)
SMILES Code
O=C(NN(C(C1=CC=CC=C1)=O)C(C)(C)C)C2=CC=C(Cl)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 330.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kilani-Morakchi S, Aribi N, Farine JP, Smagghe G, Soltani N. Cuticular hydrocarbon profiles in Blattella germanica: effects of halofenozide, boric acid and benfuracarb. Commun Agric Appl Biol Sci. 2006;71(2 Pt B):555-62. PubMed PMID: 17385524. 2: Soltani N, Chouahda S, Smagghe G. Evaluation of halofenozide against prey mosquito larvae Culex pipiens and the predator fish Gambusia affinis: impact on growth and enzymatic activities. Commun Agric Appl Biol Sci. 2008;73(3):659-66. PubMed PMID: 19226809. 3: Gardner DS, Branham BE. Mobility and dissipation of ethofumesate and halofenozide in turfgrass and bare soil. J Agric Food Chem. 2001 Jun;49(6):2894-8. PubMed PMID: 11409984. 4: Wen F, Caputo G, Hooey S, Bowman S, Pinkney K, Krell PJ, Arif B, Doucet D. Establishment of a cell line from the ash and privet borer beetle Tylonotus bimaculatus Haldeman and assessment of its sensitivity to diacylhydrazine insecticides. In Vitro Cell Dev Biol Anim. 2015 Oct;51(9):905-14. doi: 10.1007/s11626-015-9917-8. Epub 2015 May 8. PubMed PMID: 25952767. 5: Raina AK, Park YI, Hruska Z. Ecdysone agonist halofenozide affects corpora allata and reproductive physiology of the Formosan subterranean termite, Coptotermes formosanus. J Insect Physiol. 2003 Jul;49(7):677-83. PubMed PMID: 12837320. 6: Kunkel BA, Held DW, Potter DA. Lethal and sublethal effects of bendiocarb, halofenozide, and imidacloprid on Harpalus pennsylvanicus (Coleoptera: Carabidae) following different modes of exposure in turfgrass. J Econ Entomol. 2001 Feb;94(1):60-7. PubMed PMID: 11233134. 7: Guo WC, Liu XP, Fu KY, Shi JF, Lü FG, Li GQ. Functions of nuclear receptor HR3 during larval-pupal molting in Leptinotarsa decemlineata (Say) revealed by in vivo RNA interference. Insect Biochem Mol Biol. 2015 Aug;63:23-33. doi: 10.1016/j.ibmb.2015.05.010. Epub 2015 May 22. PubMed PMID: 26005119. 8: Mannion CM, Winkler HE, Shapiro DI, Gibb T. Interaction between halofenozide and the entomopathogenic nematode Heterorhabditis marelatus for control of Japanese beetle (Coleoptera: Scarabaeidae) larvae. J Econ Entomol. 2000 Feb;93(1):48-53. PubMed PMID: 14658511. 9: Guo WC, Liu XP, Fu KY, Shi JF, Lü FG, Li GQ. Nuclear receptor ecdysone-induced protein 75 is required for larval-pupal metamorphosis in the Colorado potato beetle Leptinotarsa decemlineata (Say). Insect Mol Biol. 2016 Feb;25(1):44-57. doi: 10.1111/imb.12197. Epub 2015 Nov 6. PubMed PMID: 26542892. 10: Boudjelida H, Bouaziz A, Smagghe G, Soltani N. Insecticidal activity of a nonsteroidal moulting hormone agonist on mosquito larvae and effects on ecdysteroid amounts. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2002;67(3):657-63. PubMed PMID: 12696434. 11: Farin s GP, Smagghe G, Tirry L, Castanera P. Action and pharmacokinetics of a novel insect growth regulator, halofenozide, in adult beetles of aubeonymus mariaefranciscae and leptinotarsa decemlineata . Arch Insect Biochem Physiol. 1999;41(4):201-13. PubMed PMID: 10421894. 12: Schneider MI, Smagghe G, Gobbi A, Viñuela E. Toxicity and pharmacokinetics of insect growth regulators and other novel insecticides on pupae of Hyposoter didmator (Hymenoptera: Ichneumonidae), a parasitoid of early larval instars of lepidopteran pests. J Econ Entomol. 2003 Aug;96(4):1054-65. PubMed PMID: 14503575. 13: Shi JF, Mu LL, Guo WC, Li GQ. IDENTIFICATION AND HORMONE INDUCTION OF PUTATIVE CHITIN SYNTHASE GENES AND SPLICE VARIANTS IN Leptinotarsa decemlineata (SAY). Arch Insect Biochem Physiol. 2016 Aug;92(4):242-58. doi: 10.1002/arch.21331. Epub 2016 Mar 31. PubMed PMID: 27030662. 14: Morou E, Lirakis M, Pavlidi N, Zotti M, Nakagawa Y, Smagghe G, Vontas J, Swevers L. A new dibenzoylhydrazine with insecticidal activity against Anopheles mosquito larvae. Pest Manag Sci. 2013 Jul;69(7):827-33. doi: 10.1002/ps.3441. Epub 2012 Dec 4. PubMed PMID: 23208761. 15: Jiang K, Zhang H, Wang J, Li F, Qian M. Fragmentation of deprotonated diacylhydrazine derivatives in electrospray ionization tandem mass spectrometry: generation of acid anions via intramolecular rearrangement. PLoS One. 2013 May 21;8(5):e63097. doi: 10.1371/journal.pone.0063097. Print 2013. PubMed PMID: 23704891; PubMed Central PMCID: PMC3660572. 16: Zenger JT, Gibb TJ. Impact of four insecticides on Japanese beetle (Coleoptera: Scarabaeidae) egg predators and white grubs in turfgrass. J Econ Entomol. 2001 Feb;94(1):145-9. PubMed PMID: 11233105. 17: Kong Y, Liu XP, Wan PJ, Shi XQ, Guo WC, Li GQ. The P450 enzyme Shade mediates the hydroxylation of ecdysone to 20-hydroxyecdysone in the Colorado potato beetle, Leptinotarsa decemlineata. Insect Mol Biol. 2014 Oct;23(5):632-43. doi: 10.1111/imb.12115. Epub 2014 Jul 2. PubMed PMID: 24989229. 18: Sánchez-Ramos I, Castañera P. Laboratory evaluation of selective pesticides against the storage mite Tyrophagus putrescentiae (Acari: Acaridae). J Med Entomol. 2003 Jul;40(4):475-81. PubMed PMID: 14680114. 19: Oliver JB, Mannion CM, Klein MG, Moyseenko JJ, Bishop B. Effect of insecticides on Tiphia vernalis (Hymenoptera: Tiphiidae) oviposition and survival of progeny to cocoon stage when parasitizing Popillia japonica (Coleoptera: Scarabaeidae) larvae. J Econ Entomol. 2005 Jun;98(3):694-703. PubMed PMID: 16022295. 20: Nakagawa Y. Nonsteroidal ecdysone agonists. Vitam Horm. 2005;73:131-73. Review. PubMed PMID: 16399410.

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A-315675

A-315675