Azelaprag, also known as AMG986, is a novel apelin receptor (APJ) agonist that improves cardiac contractility in animal models without adversely impacting hemodynamics. AMG 986 activate the APJ receptor in a manner similar to the endogenous ligands. AMG 986 inhibited forskolin-stimulated cAMP production and promoted Gα protein activation. AMG 986 is well tolerated, causing no adverse effects in nonclinical toxicology models.
MedKoo Cat#: 563450
Name: Azelaprag
CAS#: 2049980-18-7
Chemical Formula: C25H29N7O4S
Exact Mass: 523.2002
Molecular Weight: 523.61
Elemental Analysis: C, 57.35; H, 5.58; N, 18.73; O, 12.22; S, 6.12
The following data is based on the product molecular weight 523.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
