MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 461276 | Name: Flumecinol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flumecinol is a hepatic enzyme (cytochrome P-450 monooxygenases) inducer.

Chemical Structure

Flumecinol
Flumecinol
CAS#56430-99-0

Theoretical Analysis

MedKoo Cat#: 461276

Name: Flumecinol

CAS#: 56430-99-0

Chemical Formula: C16H15F3O

Exact Mass: 280.1075

Molecular Weight: 280.29

Elemental Analysis: C, 68.56; H, 5.39; F, 20.33; O, 5.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Flumecinol; Zyxorin;
IUPAC/Chemical Name
1-phenyl-1-(3-(trifluoromethyl)phenyl)propan-1-ol
InChi Key
DVASNQYQOZHAJN-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15F3O/c1-2-15(20,12-7-4-3-5-8-12)13-9-6-10-14(11-13)16(17,18)19/h3-11,20H,2H2,1H3
SMILES Code
OC(C1=CC=CC=C1)(CC)C2=CC=CC(C(F)(F)F)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 280.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Turner IB, Rawlins MD, Wood P, James OF. Flumecinol for the treatment of pruritus associated with primary biliary cirrhosis. Aliment Pharmacol Ther. 1994 Jun;8(3):337-42. PubMed PMID: 7918930. 2: Szabó I, Vas A, Renczes G. Effect of flumecinol (Zixoryn) on the cytochrome P450 and cytochrome P448 dependent hepatic microsomal monooxygenase activities in male rats. Acta Physiol Hung. 1992;79(1):23-7. PubMed PMID: 1288050. 3: Klebovich I, Vereczkey L, Kerpel-Fronius S, Ringwald G, Bodrogligeti I. Pharmacokinetic studies of flumecinol in man and dog. Eur J Drug Metab Pharmacokinet. 1982;7(2):99-104. PubMed PMID: 7117300. 4: Klebovich I, Vereczkey L, Tóth E, Tamás J, Mák M, Jalsovszky G, Holly S. Metabolism of flumecinol in humans. Xenobiotica. 1987 Oct;17(10):1247-58. PubMed PMID: 3424871. 5: Klebovich I, Csetényi J, Kerpel-Fronius S, Vereczkey L. Pharmacokinetic studies of [14C]-flumecinol in humans. Arzneimittelforschung. 1987 Mar;37(3):368-71. PubMed PMID: 3593454. 6: Klebovich I, Trafikánt G, Vereczkey L. Pharmacokinetics of flumecinol in rats. Acta Pharm Hung. 1988 Jan;58(1):1-7. PubMed PMID: 3376768. 7: Sylvia LA, Gerig JT. Fluorine NMR studies of the metabolism of flumecinol (3-trifluoromethyl-alpha-ethylbenzhydrol). Drug Metab Dispos. 1993 Jan-Feb;21(1):105-13. PubMed PMID: 8095202. 8: Görög S, Herényi B, Rényei M. Estimation of impurity profiles of drugs and related materials. Part 9: HPLC investigation of flumecinol. J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):831-5. PubMed PMID: 1298390. 9: Kulsár-Gergely J, Kulcsár A. Hormonal environment and age influencing the activity of flumecinol, a synthetic enzyme inducer. Arzneimittelforschung. 1981;31(12):2101-3. PubMed PMID: 7199306. 10: Silva M, Gil L. Flumecinol, a novel inducer of testosterone 16 alpha-hydroxylation in male rats. Xenobiotica. 1990 Jul;20(7):689-97. PubMed PMID: 2238704. 11: Tamás J, Mák M, Klebovich I, Vereczkey L, Tóth E. Mass spectrometric characterization of some human metabolites of flumecinol. Biomed Environ Mass Spectrom. 1988 Feb 15;15(4):229-32. PubMed PMID: 3370363. 12: Imre K, László V, József T, Mariann M, György J, Sándor H. Metabolism of flumecinol in rats. Acta Pharm Hung. 1988 Sep;58(5):221-31. PubMed PMID: 3239397. 13: Morvay J, Török J. Effect of 3-trifluoromethyl-alpha-ethylbenzhydrol (flumecinol) on lipid peroxidation in early human placenta. Acta Physiol Hung. 1988;71(2):207-11. PubMed PMID: 3389164. 14: Klebovich I, Kapás M, Vereczkey L. Capillary gas chromatographic method for determination of flumecinol in plasma and saliva. J Chromatogr. 1983 Mar 11;273(1):207-12. PubMed PMID: 6853652. 15: Vezekenyi Z, Ferenci J, Radnai B, Horvath T, Past T, Nagy L, Jávor T. Human tolerance of flumecinol (Zixoryn, RGH-3332), its regime and dosage in healthy volunteers. Int J Clin Pharmacol Res. 1983;3(2):77-88. PubMed PMID: 6679516. 16: Klebovich I, Vereczkey L. Gas chromatographic method for the determination of flumecinol in biological fluids. J Chromatogr. 1980 Dec 12;221(2):403-7. PubMed PMID: 7217310. 17: Siemens W, Xander C, Meerpohl JJ, Buroh S, Antes G, Schwarzer G, Becker G. Pharmacological interventions for pruritus in adult palliative care patients. Cochrane Database Syst Rev. 2016 Nov 16;11:CD008320. Review. PubMed PMID: 27849111. 18: Görög S, Rényei M, Herényi B. The changing role of ultraviolet spectroscopy in drug analysis. J Pharm Biomed Anal. 1989;7(12):1527-33. PubMed PMID: 2490539. 19: Lahtela JT, Gachalyi B, Eksymä S, Hämäläinen A, Sotaniemi EA. The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man. Br J Clin Pharmacol. 1986 Jan;21(1):19-26. PubMed PMID: 3511933; PubMed Central PMCID: PMC1400813. 20: Siemens W, Xander C, Meerpohl JJ, Antes G, Becker G. Drug treatments for pruritus in adult palliative care. Dtsch Arztebl Int. 2014 Dec 12;111(50):863-70. doi: 10.3238/arztebl.2014.0863. Review. PubMed PMID: 25585583; PubMed Central PMCID: PMC4296209.