(18F)LBT 999 | CAS#940949-46-2 | PET tracer

MedKoo Cat#: 598501 | Name: (18F)LBT 999

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(18F)LBT 999 is a positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat brain.

Chemical Structure

(18F)LBT 999

CAS#940949-46-2

Theoretical Analysis

MedKoo Cat#: 598501

Name: (18F)LBT 999

CAS#: 940949-46-2

Chemical Formula: C20H2618FNO2

Exact Mass: 330.1973

Molecular Weight: 330.43

Elemental Analysis: C, 72.70; H, 7.93; F, 5.45; N, 4.24; O, 9.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

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Synonym

(18F)LBT 999; (18F)LBT-999; (18F)LBT999; LBT 999 18F; LBT-999 18F; LBT999 18F;

IUPAC/Chemical Name

methyl (E)-8-(4-(fluoro-18F)but-2-en-1-yl)-3-(p-tolyl)-8-azabicyclo[3.2.1]octane-2-carboxylate

InChi Key

XZWRXMFAFBSAJC-YQBCICDLSA-N

InChi Code

InChI=1S/C20H26FNO2/c1-14-5-7-15(8-6-14)17-13-16-9-10-18(19(17)20(23)24-2)22(16)12-4-3-11-21/h3-8,16-19H,9-13H2,1-2H3/b4-3+/i21-1

SMILES Code

COC(C1C2CCC(N2C/C=C/C[18F])CC1c3ccc(C)cc3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 330.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sérrière S, Tauber C, Vercouillie J, Guilloteau D, Deloye JB, Garreau L, Galineau L, Chalon S. In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999. Nucl Med Biol. 2014 Jan;41(1):106-13. doi: 10.1016/j.nucmedbio.2013.09.007. Epub 2013 Oct 8. PubMed PMID: 24210285. 2: Saba W, Peyronneau MA, Dollé F, Goutal S, Bottlaender M, Valette H. Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling Part I: PET studies. Nucl Med Biol. 2012 Feb;39(2):227-33. doi: 10.1016/j.nucmedbio.2011.08.003. Epub 2011 Oct 26. PubMed PMID: 22033025. 3: Peyronneau MA, Saba W, Dollé F, Goutal S, Coulon C, Bottlaender M, Valette H. Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling: part II: Metabolism studies. Nucl Med Biol. 2012 Apr;39(3):347-59. doi: 10.1016/j.nucmedbio.2011.09.006. Epub 2011 Dec 11. PubMed PMID: 22154687.