RFI-641 | CAS#197366-24-8 | nti-RSV agent

MedKoo Cat#: 461271 | Name: RFI-641

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RFI-641 is a small dendrimer-like compound with anti-RSV properties and is potent in vitro and in vivo activity.

Chemical Structure

RFI-641

CAS#197366-24-8

Theoretical Analysis

MedKoo Cat#: 461271

Name: RFI-641

CAS#: 197366-24-8

Chemical Formula: C58H60N24Na2O22S6

Exact Mass: 1682.2434

Molecular Weight: 1683.60

Elemental Analysis: C, 41.38; H, 3.59; N, 19.97; Na, 2.73; O, 20.91; S, 11.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

RFI-641; RFI 641; RFI641;

IUPAC/Chemical Name

sodium 4,4'-bis((4,6-bis((3-(N-(2-((2-amino-2-oxoethyl)amino)-2-oxoethyl)sulfamoyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)-[1,1'-biphenyl]-2,2'-disulfonate

InChi Key

KMNJIAUXWBFEIA-UHFFFAOYSA-L

InChi Code

InChI=1S/C58H62N24O22S6.2Na/c59-45(83)23-63-49(87)27-67-105(91,92)37-9-1-5-31(17-37)71-53-77-54(72-32-6-2-10-38(18-32)106(93,94)68-28-50(88)64-24-46(60)84)80-57(79-53)75-35-13-15-41(43(21-35)109(99,100)101)42-16-14-36(22-44(42)110(102,103)104)76-58-81-55(73-33-7-3-11-39(19-33)107(95,96)69-29-51(89)65-25-47(61)85)78-56(82-58)74-34-8-4-12-40(20-34)108(97,98)70-30-52(90)66-26-48(62)86;;/h1-22,67-70H,23-30H2,(H2,59,83)(H2,60,84)(H2,61,85)(H2,62,86)(H,63,87)(H,64,88)(H,65,89)(H,66,90)(H,99,100,101)(H,102,103,104)(H3,71,72,75,77,79,80)(H3,73,74,76,78,81,82);;/q;2*+1/p-2

SMILES Code

O=S(C1=CC(NC2=NC(NC3=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C3)=NC(NC4=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C4)=N2)=CC=C1C5=CC=C(NC6=NC(NC7=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C7)=NC(NC8=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C8)=N6)C=C5S(=O)([O-])=O)([O-])=O.[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,683.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nikitenko AA, Raifeld YE, Wang TZ. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. PubMed PMID: 11327584. 2: Huntley CC, Weiss WJ, Gazumyan A, Buklan A, Feld B, Hu W, Jones TR, Murphy T, Nikitenko AA, O'Hara B, Prince G, Quartuccio S, Raifeld YE, Wyde P, O'Connell JF. RFI-641, a potent respiratory syncytial virus inhibitor. Antimicrob Agents Chemother. 2002 Mar;46(3):841-7. PubMed PMID: 11850270; PubMed Central PMCID: PMC127488. 3: Weiss WJ, Murphy T, Lynch ME, Frye J, Buklan A, Gray B, Lenoy E, Mitelman S, O'Connell J, Quartuccio S, Huntley C. Inhalation efficacy of RFI-641 in an African green monkey model of RSV infection. J Med Primatol. 2003 Apr;32(2):82-8. PubMed PMID: 12823630. 4: Razinkov V, Gazumyan A, Nikitenko A, Ellestad G, Krishnamurthy G. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001 Jul;8(7):645-59. PubMed PMID: 11451666. 5: Razinkov V, Huntley C, Ellestad G, Krishnamurthy G. RSV entry inhibitors block F-protein mediated fusion with model membranes. Antiviral Res. 2002 Jul;55(1):189-200. PubMed PMID: 12076763.