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MedKoo Cat#: 598492 | Name: Erythrosine B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Erythrosine sodium (close form) is a tetraiodofluorescein used as a red coloring in some foods (cherries, fish), as a disclosure of DENTAL PLAQUE, and as a stain of some cell types. It has structural similarity to THYROXINE.

Chemical Structure

Erythrosine B
Erythrosine B
CAS#16423-68-0

Theoretical Analysis

MedKoo Cat#: 598492

Name: Erythrosine B

CAS#: 16423-68-0

Chemical Formula: C20H6I4Na2O5

Exact Mass: 0.0000

Molecular Weight: 879.86

Elemental Analysis: C, 27.30; H, 0.69; I, 57.69; Na, 5.23; O, 9.09

Price and Availability

Size Price Availability Quantity
25g USD 350.00 2 Weeks
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Synonym
Erythrosine sodium (close form); CI 45430; CI-45430 CI45430; Erythrosin B; Erythrosine B; C.I. Acid Red 51; FD&C Red No. 3; Iodoeosine Sodium Salt; Tetraiodofluorescein Sodium Salt
IUPAC/Chemical Name
sodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)
InChi Key
RAGZEDHHTPQLAI-UHFFFAOYSA-L
InChi Code
InChI=1S/C20H8I4O5.2Na/c21-11-5-9-17(13(23)15(11)25)28-18-10(6-12(22)16(26)14(18)24)20(9)8-4-2-1-3-7(8)19(27)29-20;;/h1-6,25-26H;;/q;2*+1/p-2
SMILES Code
O=C1OC2(C3=C(OC4=C2C=C(I)C([O-])=C4I)C(I)=C([O-])C(I)=C3)C5=C1C=CC=C5.[Na+].[Na+]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 879.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Havlíková M, Huličiak M, Bazgier V, Berka K, Kubala M. Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase. Biochim Biophys Acta. 2013 Feb;1828(2):568-76. doi: 10.1016/j.bbamem.2012.10.029. Epub 2012 Nov 8. PubMed PMID: 23142565. 2: Jennings AS, Schwartz SL, Balter NJ, Gardner D, Witorsch RJ. Effects of oral erythrosine (2',4',5',7'-tetraiodofluorescein) on the pituitary-thyroid axis in rats. Toxicol Appl Pharmacol. 1990 May;103(3):549-56. PubMed PMID: 2160137. 3: Yankell SL, Loux JJ. Acute toxicity testing of erythrosine and sodium fluorescein in mice and rats. J Periodontol. 1977 Apr;48(4):228-31. PubMed PMID: 265392. 4: Lakdawalla AA, Netrawali MS. Mutagenicity, comutagenicity, and antimutagenicity of erythrosine (FD and C red 3), a food dye, in the Ames/Salmonella assay. Mutat Res. 1988 Feb;204(2):131-9. PubMed PMID: 2830505. 5: Zhu X, Sun J, Hu Y. Determination of protein by hydroxypropyl-beta-cyclodextrin sensitized fluorescence quenching method with erythrosine sodium as a fluorescence probe. Anal Chim Acta. 2007 Jul 23;596(2):298-302. Epub 2007 Jun 13. PubMed PMID: 17631110. 6: Prestwich RJ, Gerrard GE. Low-iodine diet before radioiodine uptake scans or therapy--flawed advice to U.K. patients. Clin Oncol (R Coll Radiol). 2005 Apr;17(2):73-4. PubMed PMID: 15830566. 7: Rogers CG, Boyes BG, Matula TI, Héroux-Metcalf C, Clayson DB. A multiple end-point approach to evaluation of cytotoxicity and genotoxicity of erythrosine (FD and C Red No. 3) in a V79 hepatocyte-mediated mutation assay. Mutat Res. 1988 May-Aug;205(1-4):415-23. PubMed PMID: 2835676. 8: Fricke U. Two ouabain binding sites in guinea pig heart Na+-K+-ATPase. Differentiation by sodium and erythrosin B. Basic Res Cardiol. 1984;79 Suppl:119-27. PubMed PMID: 6331371. 9: Cuthbert AW. Calcium-dependent chloride secretion in rat colon epithelium. J Physiol. 1985 Apr;361:1-17. PubMed PMID: 2985775; PubMed Central PMCID: PMC1192843. 10: Charlton SC, Fleming RL, Zipp A. Solid-phase colorimetric determination of potassium. Clin Chem. 1982 Sep;28(9):1857-61. PubMed PMID: 6290106. 11: Mittal A, Mittal J, Kurup L, Singh AK. Process development for the removal and recovery of hazardous dye erythrosine from wastewater by waste materials-Bottom Ash and De-Oiled Soya as adsorbents. J Hazard Mater. 2006 Nov 2;138(1):95-105. Epub 2006 May 20. PubMed PMID: 16806679. 12: Pereira CA, Costa AC, Carreira CM, Junqueira JC, Jorge AO. Photodynamic inactivation of Streptococcus mutans and Streptococcus sanguinis biofilms in vitro. Lasers Med Sci. 2013 May;28(3):859-64. doi: 10.1007/s10103-012-1175-3. Epub 2012 Jul 31. PubMed PMID: 22847685. 13: Mai HT, Brodie DL, Meyers MB, Baldo AL, Krantz Z, Weisz A. Determination of 2,4,6-triiodoresorcinol and other side reaction products and intermediates in the colour additive FD&C Red No. 3 (erythrosine) using high-performance liquid chromatography. Food Addit Contam. 2006 Jun;23(6):547-51. PubMed PMID: 16766453. 14: Smith PA, Dombro KR, Zidichouski J. Effect of erythrosin B on hyperpolarizing responses to catecholamines in amphibian sympathetic ganglia. J Pharmacol Exp Ther. 1984 Jul;230(1):221-7. PubMed PMID: 6086877. 15: Augustine GJ, Levitan H. Presynaptic effect of Erythrosin B at the frog neuromuscular junction: ion and photon sensitivity. J Physiol. 1983 Jan;334:65-77. PubMed PMID: 6306232; PubMed Central PMCID: PMC1197300. 16: Tabara A, Yamane C, Seguchi M. Adsorption mechanism for xanthene dyes to cellulose granules. Biosci Biotechnol Biochem. 2012;76(5):870-4. Epub 2012 May 7. PubMed PMID: 22738951. 17: Antonelli MC, Baskin DG, Garland M, Stahl WL. Localization and characterization of binding sites with high affinity for [3H]ouabain in cerebral cortex of rabbit brain using quantitative autoradiography. J Neurochem. 1989 Jan;52(1):193-200. PubMed PMID: 2535710. 18: Mazari AM, Hegazy UM, Mannervik B. Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds. Chem Biol Interact. 2015 Mar 5;229:91-9. doi: 10.1016/j.cbi.2015.01.014. Epub 2015 Jan 17. PubMed PMID: 25603235. 19: Jenkins S, Addy M, Newcome R. Triclosan and sodium lauryl sulphate mouthrinses. (II). Effects of 4-day plaque regrowth. J Clin Periodontol. 1991 Feb;18(2):145-8. PubMed PMID: 1848567. 20: You Y, Ludescher RD. The effect of sodium chloride on molecular mobility in amorphous sucrose detected by phosphorescence from the triplet probe erythrosin B. Carbohydr Res. 2008 Feb 4;343(2):350-63. Epub 2007 Nov 13. PubMed PMID: 18048018.