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MedKoo Cat#: 461258 | Name: Indoprofen
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indoprofen is a non-steroidal anti-inflammatory drug. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market.

Chemical Structure

Indoprofen
Indoprofen
CAS#31842-01-0

Theoretical Analysis

MedKoo Cat#: 461258

Name: Indoprofen

CAS#: 31842-01-0

Chemical Formula: C17H15NO3

Exact Mass: 281.1052

Molecular Weight: 281.31

Elemental Analysis: C, 72.58; H, 5.37; N, 4.98; O, 17.06

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 Weeks
100mg USD 400.00 2 Weeks
250mg USD 650.00 2 Weeks
1g USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Indoprofen; Flosint; Isindone; K 4277; K-4277; K4277; Reumofene;
IUPAC/Chemical Name
2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid
InChi Key
RJMIEHBSYVWVIN-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)
SMILES Code
O=C(O)C(C)C1=CC=C(N(CC2=C3C=CC=C2)C3=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Trzcionka J, Lhiaubet-Vallet V, Chouini-Lalanne N. DNA photosensitization by indoprofen - is DNA damage photoinduced by indoprofen or by its photoproducts? Photochem Photobiol Sci. 2004 Feb;3(2):226-30. Epub 2003 Nov 20. PubMed PMID: 14872241. 2: Loizzi P, Muratore M, Bruni G, Sacchetti G. A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis. Curr Med Res Opin. 1980;6(9):598-605. PubMed PMID: 7408527. 3: Innocenti PF, Bruni G, Mandelli V, Ferrati GC. Indoprofen versus ibuprofen in osteoarthrosis: a short-term, double-blind, crossover trial. Curr Med Res Opin. 1979;5(10):793-8. PubMed PMID: 373995. 4: Melander A, Wåhlin-Boll E. Kinetic interaction of glipizide and indoprofen in healthy volunteers. Acta Endocrinol Suppl (Copenh). 1980;239:9-10. PubMed PMID: 6933822. 5: Tamassia V. Human pharmacokinetics of indoprofen. Eur J Rheumatol Inflamm. 1981;4(1):11-5. PubMed PMID: 7341274. 6: Tamassia V, Jannuzzo MG, Moro E, Stegnjaich S, Groppi W, Nicolis FB. Pharmacokinetics of the enantiomers of indoprofen in man. Int J Clin Pharmacol Res. 1984;4(3):223-30. PubMed PMID: 6490241. 7: Siebler D, Kinawi A. [Binding of racemic indoprofen and its enantiomers to human serum albumin]. Arzneimittelforschung. 1989 Jun;39(6):659-60. German. PubMed PMID: 2775332. 8: Persson NH, Bergqvist D, Melander A, Zederfelt B. Comparison of a narcotic (oxicone) and a non-narcotic anti-inflammatory analgesic (indoprofen) in the treatment of renal colic. Acta Chir Scand. 1985;151(2):105-8. PubMed PMID: 3890435. 9: Stygles VG, Commassaris RA, Rech RH, Hook JB. The effect of indoprofen on phenylquinone-writhing and prostaglandin synthesis. Arch Int Pharmacodyn Ther. 1978 Sep;235(1):43-50. PubMed PMID: 736691. 10: Marcolongo R, Lucchese M, Caruso I, Fumagalli M, Bruni G, Sacchetti G. Intravenous indoprofen for prompt relief of acute gout: a regimen-finding study. J Int Med Res. 1980;8(5):326-32. PubMed PMID: 6998792. 11: Kurowski M. Pharmacokinetics of indoprofen in elderly patients following repeated oral administration. Int J Clin Pharmacol Res. 1985;5(4):255-63. PubMed PMID: 4055168. 12: Pedrazzi F, Bommartini F, Freddo J, Emanueli A. A study of the possible interaction of indoprofen with hypoglycemic sulfonylureas in diabetic patients. Eur J Rheumatol Inflamm. 1981;4(1):26-31. PubMed PMID: 7042358. 13: Olstad OA, Skjelbred P. The effects of indoprofen vs paracetamol on swelling, pain and other events after surgery. Int J Clin Pharmacol Ther Toxicol. 1986 Jan;24(1):34-8. PubMed PMID: 3514486. 14: Melander A, Wåhlin-Boll E. Interaction of glipizide and indoprofen. Eur J Rheumatol Inflamm. 1981;4(1):22-5. PubMed PMID: 7341277. 15: Okun R, Green JW, Shackleford RW. An analgesic comparison study of indoprofen versus aspirin and placebo in surgical pain. J Clin Pharmacol. 1979 Aug-Sep;19(8-9 Pt 1):487-92. PubMed PMID: 489767. 16: Buttinoni A, Tommasini R. Preclinical studies on indoprofen, a new non-steroidal analgesic-antiinflammatory agent. Eur J Rheumatol Inflamm. 1981;4(1):3-10. PubMed PMID: 6804240. 17: Huskisson EC, Scott J, Woolf DL. Three trials of indoprofen. Eur J Rheumatol Inflamm. 1981;4(1):97-102. PubMed PMID: 7042369. 18: Torchi B, Villani U, Bruni G, Lavezzari M, Mandelli V. Intravenous indoprofen in the management of renal colic. Int J Clin Pharmacol Res. 1983;3(3):167-73. PubMed PMID: 6384073. 19: Sunshine A, Zighelboim I, Olson NZ, De Sarrazin C, Laska E. A comparative oral analgesic study of indoprofen, aspirin, and placebo in postpartum pain. J Clin Pharmacol. 1985 Jul-Aug;25(5):374-80. PubMed PMID: 3897296. 20: Sartani A, Papatheodossiou N, Parrinello L, Mandelli V. A study of the analgesic potency of indoprofen and pentazocine in postoperative pain. J Clin Pharmacol. 1985 Nov-Dec;25(8):596-600. PubMed PMID: 4078027.