MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 592548 | Name: Bacilysin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bacilysin is a dipeptide antibiotic produced by certain Bacillus species, comprising L-alanine and L-anticapsin. It exhibits broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as some fungi. Its primary mechanism of action involves inhibition of cell wall synthesis, typically by targeting peptidoglycan precursors. Bacilysin’s bioactivity and relatively simple structure make it a model compound for studying natural antibiotic biosynthesis and potential applications in medicine and agriculture.

Chemical Structure

Bacilysin
Bacilysin
CAS#29393-20-2

Theoretical Analysis

MedKoo Cat#: 592548

Name: Bacilysin

CAS#: 29393-20-2

Chemical Formula: C12H18N2O5

Exact Mass: 270.1216

Molecular Weight: 270.29

Elemental Analysis: C, 53.33; H, 6.71; N, 10.36; O, 29.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
KM-208; KM 208; Bacilysin
IUPAC/Chemical Name
7-Oxabicyclo(4.1.0)heptane-2-propionic acid, alpha-(2-aminopropionamido)-5-oxo-, stereoisomer
InChi Key
XFOUAXMJRHNTOP-PFQXTLEHSA-N
InChi Code
InChI=1S/C12H18N2O5/c1-5(13)11(16)14-7(12(17)18)4-6-2-3-8(15)10-9(6)19-10/h5-7,9-10H,2-4,13H2,1H3,(H,14,16)(H,17,18)/t5-,6-,7-,9+,10-/m0/s1
SMILES Code
C[C@@H](C(N[C@H](C(O)=O)C[C@@H]1CCC([C@@H]2O[C@H]12)=O)=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 270.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen L, Heng J, Qin S, Bian K. A comprehensive understanding of the biocontrol potential of Bacillus velezensis LM2303 against Fusarium head blight. PLoS One. 2018 Jun 1;13(6):e0198560. doi: 10.1371/journal.pone.0198560. eCollection 2018. PubMed PMID: 29856856; PubMed Central PMCID: PMC5983450. 2: Wu J, Xu G, Jin Y, Sun C, Zhou L, Lin G, Xu R, Wei L, Fei H, Wang D, Chen J, Lv Z, Liu K. Isolation and characterization of Bacillus sp. GFP-2, a novel Bacillus strain with antimicrobial activities, from Whitespotted bamboo shark intestine. AMB Express. 2018 May 22;8(1):84. doi: 10.1186/s13568-018-0614-3. PubMed PMID: 29785529; PubMed Central PMCID: PMC5962526. 3: Wang T, Liu XH, Wu MB, Ge S. Molecular insights into the antifungal mechanism of bacilysin. J Mol Model. 2018 Apr 26;24(5):118. doi: 10.1007/s00894-018-3645-4. PubMed PMID: 29700621. 4: Sagredo-Beltrán J, De La Cruz-Rodríguez Y, Alvarado-Rodríguez M, Vega-Arreguín J, Rodríguez-Guerra R, Alvarado-Gutiérrez A, Fraire-Velázquez S. Genome Sequence of Bacillus halotolerans Strain MS50-18A with Antifungal Activity against Phytopathogens, Isolated from Saline Soil in San Luís Potosí, Mexico. Genome Announc. 2018 Mar 8;6(10). pii: e00135-18. doi: 10.1128/genomeA.00135-18. PubMed PMID: 29519837; PubMed Central PMCID: PMC5843726. 5: Caulier S, Gillis A, Colau G, Licciardi F, Liépin M, Desoignies N, Modrie P, Legrève A, Mahillon J, Bragard C. Versatile Antagonistic Activities of Soil-Borne Bacillus spp. and Pseudomonas spp. against Phytophthora infestans and Other Potato Pathogens. Front Microbiol. 2018 Feb 13;9:143. doi: 10.3389/fmicb.2018.00143. eCollection 2018. PubMed PMID: 29487574; PubMed Central PMCID: PMC5816801. 6: Chen L, Gu W, Xu HY, Yang GL, Shan XF, Chen G, Wang CF, Qian AD. Complete genome sequence of Bacillus velezensis 157 isolated from Eucommia ulmoides with pathogenic bacteria inhibiting and lignocellulolytic enzymes production by SSF. 3 Biotech. 2018 Feb;8(2):114. doi: 10.1007/s13205-018-1125-2. Epub 2018 Feb 6. PubMed PMID: 29430375; PubMed Central PMCID: PMC5801104. 7: Wu G, Liu Y, Xu Y, Zhang G, Shen Q, Zhang R. Exploring Elicitors of the Beneficial Rhizobacterium Bacillus amyloliquefaciens SQR9 to Induce Plant Systemic Resistance and Their Interactions With Plant Signaling Pathways. Mol Plant Microbe Interact. 2018 May;31(5):560-567. doi: 10.1094/MPMI-11-17-0273-R. Epub 2018 Mar 23. PubMed PMID: 29309236. 8: Liu K, Newman M, McInroy JA, Hu CH, Kloepper JW. Selection and Assessment of Plant Growth-Promoting Rhizobacteria for Biological Control of Multiple Plant Diseases. Phytopathology. 2017 Aug;107(8):928-936. doi: 10.1094/PHYTO-02-17-0051-R. Epub 2017 Jun 13. PubMed PMID: 28440700. 9: Vinodkumar S, Nakkeeran S, Renukadevi P, Malathi VG. Biocontrol Potentials of Antimicrobial Peptide Producing Bacillus Species: Multifaceted Antagonists for the Management of Stem Rot of Carnation Caused by Sclerotinia sclerotiorum. Front Microbiol. 2017 Mar 24;8:446. doi: 10.3389/fmicb.2017.00446. eCollection 2017. PubMed PMID: 28392780; PubMed Central PMCID: PMC5364326. 10: Liu G, Kong Y, Fan Y, Geng C, Peng D, Sun M. Whole-genome sequencing of Bacillus velezensis LS69, a strain with a broad inhibitory spectrum against pathogenic bacteria. J Biotechnol. 2017 May 10;249:20-24. doi: 10.1016/j.jbiotec.2017.03.018. Epub 2017 Mar 18. PubMed PMID: 28323017. 11: Perinbam K, Balaram H, Guru Row TN, Gopal B. Probing the influence of non-covalent contact networks identified by charge density analysis on the oxidoreductase BacC. Protein Eng Des Sel. 2017 Mar 1;30(3):265-272. doi: 10.1093/protein/gzx006. PubMed PMID: 28158843. 12: Khan MA, Göpel Y, Milewski S, Görke B. Two Small RNAs Conserved in Enterobacteriaceae Provide Intrinsic Resistance to Antibiotics Targeting the Cell Wall Biosynthesis Enzyme Glucosamine-6-Phosphate Synthase. Front Microbiol. 2016 Jun 15;7:908. doi: 10.3389/fmicb.2016.00908. eCollection 2016. PubMed PMID: 27379045; PubMed Central PMCID: PMC4908143. 13: Liu H, Yin S, An L, Zhang G, Cheng H, Xi Y, Cui G, Zhang F, Zhang L. Complete genome sequence of Bacillus subtilis BSD-2, a microbial germicide isolated from cultivated cotton. J Biotechnol. 2016 Jul 20;230:26-7. doi: 10.1016/j.jbiotec.2016.05.019. Epub 2016 May 13. PubMed PMID: 27184432. 14: Sajitha KL, Dev SA, Maria Florence EJ. Identification and Characterization of Lipopeptides from Bacillus subtilis B1 Against Sapstain Fungus of Rubberwood Through MALDI-TOF-MS and RT-PCR. Curr Microbiol. 2016 Jul;73(1):46-53. doi: 10.1007/s00284-016-1025-9. Epub 2016 Mar 23. PubMed PMID: 27004481. 15: Wu L, Wu HJ, Qiao J, Gao X, Borriss R. Novel Routes for Improving Biocontrol Activity of Bacillus Based Bioinoculants. Front Microbiol. 2015 Dec 10;6:1395. doi: 10.3389/fmicb.2015.01395. eCollection 2015. Review. PubMed PMID: 26696998; PubMed Central PMCID: PMC4674565. 16: Tojo S, Tanaka Y, Ochi K. Activation of Antibiotic Production in Bacillus spp. by Cumulative Drug Resistance Mutations. Antimicrob Agents Chemother. 2015 Dec;59(12):7799-804. doi: 10.1128/AAC.01932-15. Epub 2015 Sep 14. PubMed PMID: 26369962; PubMed Central PMCID: PMC4649196. 17: Wu L, Wu H, Chen L, Yu X, Borriss R, Gao X. Difficidin and bacilysin from Bacillus amyloliquefaciens FZB42 have antibacterial activity against Xanthomonas oryzae rice pathogens. Sci Rep. 2015 Aug 13;5:12975. doi: 10.1038/srep12975. PubMed PMID: 26268540; PubMed Central PMCID: PMC4534799. 18: Wang T, Wu MB, Chen ZJ, Lin JP, Yang LR. Separation, determination and antifungal activity test of the products from a new Bacillus amyloliquefaciens. Nat Prod Res. 2016;30(10):1215-8. doi: 10.1080/14786419.2015.1048246. Epub 2015 Jul 3. PubMed PMID: 26140441. 19: Gan HY, Gan HM, Savka MA, Triassi AJ, Wheatley MS, Naqvi KF, Foxhall TE, Anauo MJ, Baldwin ML, Burkhardt RN, O'Bryon IG, Dailey LK, Busairi NI, Keith RC, Khair MH, Rasul MZ, Rosdi NA, Mountzouros JR, Rhoads AC, Selochan MA, Tautanov TB, Polter SJ, Marks KD, Caraballo AA, Hudson AO. Whole-Genome Sequencing and Annotation of Bacillus safensis RIT372 and Pseudomonas oryzihabitans RIT370 from Capsicum annuum (Bird's Eye Chili) and Capsicum chinense (Yellow Lantern Chili), Respectively. Genome Announc. 2015 Apr 16;3(2). pii: e00288-15. doi: 10.1128/genomeA.00288-15. PubMed PMID: 25883290; PubMed Central PMCID: PMC4400433. 20: Guo S, Li X, He P, Ho H, Wu Y, He Y. Whole-genome sequencing of Bacillus subtilis XF-1 reveals mechanisms for biological control and multiple beneficial properties in plants. J Ind Microbiol Biotechnol. 2015 Jun;42(6):925-37. doi: 10.1007/s10295-015-1612-y. Epub 2015 Apr 10. PubMed PMID: 25860123.