MedKoo Cat#: 572134 | Name: Azido-PEG2-t-Boc-hydrazide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azido-PEG2-t-Boc-hydrazide is a PEG derivative containing an azide group and a Boc-protected hydrazide. The azide group can react with alkyne groups, BCN, and DBCO via Click Chemistry to yield a stable triazole linkage. The Boc can be deprotected under mild acidic conditions to form a reactive hydrazide, which can then be coupled with various carbonyl groups.

Chemical Structure

Azido-PEG2-t-Boc-hydrazide
Azido-PEG2-t-Boc-hydrazide
CAS#2100306-56-5

Theoretical Analysis

MedKoo Cat#: 572134

Name: Azido-PEG2-t-Boc-hydrazide

CAS#: 2100306-56-5

Chemical Formula: C12H23N5O5

Exact Mass: 317.1699

Molecular Weight: 317.35

Elemental Analysis: C, 45.42; H, 7.31; N, 22.07; O, 25.21

Price and Availability

Size Price Availability Quantity
100mg USD 550.00 2 Weeks
250mg USD 950.00 2 Weeks
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Synonym
Azido-PEG2-t-Boc-hydrazide
IUPAC/Chemical Name
tert-butyl 2-(3-(2-(2-azidoethoxy)ethoxy)propanoyl)hydrazine-1-carboxylate
InChi Key
JYNHRXFEKXQQDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H23N5O5/c1-12(2,3)22-11(19)16-15-10(18)4-6-20-8-9-21-7-5-14-17-13/h4-9H2,1-3H3,(H,15,18)(H,16,19)
SMILES Code
O=C(OC(C)(C)C)NNC(CCOCCOCCN=[N+]=[N-])=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
The hydrophilic PEG spacer increases solubility in aqueous media.

Preparing Stock Solutions

The following data is based on the product molecular weight 317.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141. 2: Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjug Chem. 2009 Jun;20(6):1179-85. doi: 10.1021/bc9000432. PubMed PMID: 19469471.