Related CAS #
175217-20-6
Synonym
Silthiofam; MON-65500; MON 65500; MON65500; Silthiopham; Latitude;
IUPAC/Chemical Name
N-allyl-4,5-dimethyl-2-(trimethylsilyl)thiophene-3-carboxamide
InChi Key
MXMXHPPIGKYTAR-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21NOSSi/c1-7-8-14-12(15)11-9(2)10(3)16-13(11)17(4,5)6/h7H,1,8H2,2-6H3,(H,14,15)
SMILES Code
O=C(C1=C([Si](C)(C)C)SC(C)=C1C)NCC=C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Silthiofam is a fungicide.
In vitro activity:
Silthiofam is very effective against Ggt, but resistance to the fungicide is emerging. Of 66 Ggt isolates tested, 27 had resistance to silthiogam, but there was no cross-resistance observed with tecuconazole or difenoconazole. Management practices for take-all may need to adapt as silthiofam resistance grows.
Reference: Pest Manag Sci. 2012 Aug;68(8):1156-63. https://pubmed.ncbi.nlm.nih.gov/22411909/
In vivo activity:
The study examined take-all dynamics in crops with varying cropping history using an epidemiological model. Silthiofam seed treatment showed no consistent impact on take-all decline. The findings suggest low initial inoculum levels leading to weak disease suppression in the first wheat crop, followed by amplification and subsequent equilibrium with antagonist populations, influencing overall infection and disease severity.
Reference: Phytopathology. 2009 Jul;99(7):861-8. https://pubmed.ncbi.nlm.nih.gov/19522584/
Preparing Stock Solutions
The following data is based on the
product
molecular weight
267.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Yun Y, Yu F, Wang N, Chen H, Yin Y, Ma Z. Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China. Pest Manag Sci. 2012 Aug;68(8):1156-63. doi: 10.1002/ps.3277. Epub 2012 Mar 12. PMID: 22411909.
2. Bailey DJ, Paveley N, Spink J, Lucas P, Gilligan CA. Epidemiological analysis of take-all decline in winter wheat. Phytopathology. 2009 Jul;99(7):861-8. doi: 10.1094/PHYTO-99-7-0861. PMID: 19522584.
3. Bailey DJ, Paveley N, Pillinger C, Foulkes J, Spink J, Gilligan CA. Epidemiology and chemical control of take-all on seminal and adventitious roots of wheat. Phytopathology. 2005 Jan;95(1):62-8. doi: 10.1094/PHYTO-95-0062. PMID: 18943837.
In vitro protocol:
1. Yun Y, Yu F, Wang N, Chen H, Yin Y, Ma Z. Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China. Pest Manag Sci. 2012 Aug;68(8):1156-63. doi: 10.1002/ps.3277. Epub 2012 Mar 12. PMID: 22411909.
In vivo protocol:
1. Bailey DJ, Paveley N, Spink J, Lucas P, Gilligan CA. Epidemiological analysis of take-all decline in winter wheat. Phytopathology. 2009 Jul;99(7):861-8. doi: 10.1094/PHYTO-99-7-0861. PMID: 19522584.
2. Bailey DJ, Paveley N, Pillinger C, Foulkes J, Spink J, Gilligan CA. Epidemiology and chemical control of take-all on seminal and adventitious roots of wheat. Phytopathology. 2005 Jan;95(1):62-8. doi: 10.1094/PHYTO-95-0062. PMID: 18943837.
1: Chen X, Li Z, Cao Z, Cao X, Chen M. [Determination of six novel amide fungicides in vegetables and fruits by liquid chromatography-tandem mass spectrometry]. Se Pu. 2013 Oct;31(10):954-60. Chinese. doi: 10.3724/sp.j.1123.2013.04028. PMID: 24432637.
2: Yun Y, Yu F, Wang N, Chen H, Yin Y, Ma Z. Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China. Pest Manag Sci. 2012 Aug;68(8):1156-63. doi: 10.1002/ps.3277. Epub 2012 Mar 12. PMID: 22411909.
3: Bailey DJ, Paveley N, Spink J, Lucas P, Gilligan CA. Epidemiological analysis of take-all decline in winter wheat. Phytopathology. 2009 Jul;99(7):861-8. doi: 10.1094/PHYTO-99-7-0861. PMID: 19522584.
4: Bailey DJ, Paveley N, Pillinger C, Foulkes J, Spink J, Gilligan CA. Epidemiology and chemical control of take-all on seminal and adventitious roots of wheat. Phytopathology. 2005 Jan;95(1):62-8. doi: 10.1094/PHYTO-95-0062. PMID: 18943837.
