Relomycin | CAS#1404-48-4 | antibiotic

MedKoo Cat#: 461207 | Name: Relomycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Relomycin is a macrolide antibiotic.

Chemical Structure

Relomycin

CAS#1404-48-4

Theoretical Analysis

MedKoo Cat#: 461207

Name: Relomycin

CAS#: 1404-48-4

Chemical Formula: C46H79NO17

Exact Mass: 917.5348

Molecular Weight: 918.12

Elemental Analysis: C, 60.18; H, 8.67; N, 1.53; O, 29.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Relomycin; Dihydrotylosin; Relomicina; Relomycinum;

IUPAC/Chemical Name

(11Z,13E)-6-((5-((4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-15-(((5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-7-(2-hydroxyethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione

InChi Key

QDAVFUSCCPXZTE-XKXXACGVSA-N

InChi Code

InChI=1S/C46H79NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,18,24-30,32-33,35-45,48,50,52-55H,13,16-17,19-22H2,1-12H3/b15-14-,23-18+

SMILES Code

CCC1C(COC2C(OC)C(OC)C(O)C(C)O2)/C=C(C)/C=C\C(C(C)CC(CCO)C(OC3C(O)C(N(C)C)C(OC4CC(C)(O)C(O)C(C)O4)C(C)O3)C(C)C(O)CC(O1)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 918.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: JENSEN AL, DARKEN MA, SCHULTZ JS, SHAY AJ. RELOMYCIN: FLASK AND TANK FERMENTATION STUDIES. Antimicrob Agents Chemother (Bethesda). 1963;161:49-53. PubMed PMID: 14274950. 2: WHALEY HA, PATTERSON EL, DORNBUSH AC, BACKUS EJ, BOHONOS N. ISOLATION AND CHARACTERIZATION OF RELOMYCIN, A NEW ANTIBIOTIC. Antimicrob Agents Chemother (Bethesda). 1963;161:45-8. PubMed PMID: 14274943. 3: Seno ET, Pieper RL, Huber FM. Terminal stages in the biosynthesis of tylosin. Antimicrob Agents Chemother. 1977 Mar;11(3):455-61. PubMed PMID: 855999; PubMed Central PMCID: PMC352007. 4: Kolz AC, Moorman TB, Ong SK, Scoggin KD, Douglass EA. Degradation and metabolite production of tylosin in anaerobic and aerobic swine-manure lagoons. Water Environ Res. 2005 Jan-Feb;77(1):49-56. PubMed PMID: 15765935. 5: Huang SL, Hassell TC, Yeh WK. Purification and properties of NADPH-dependent tylosin reductase from Streptomyces fradiae. J Biol Chem. 1993 Sep 5;268(25):18987-93. PubMed PMID: 8360186. 6: Yeh WK, Bauer NJ, Dotzlaf JE. High-performance liquid chromatographic assay for S-adenosyl-L-methionine: macrocin O-methyltransferase. J Chromatogr. 1984 Apr 20;288(1):157-65. PubMed PMID: 6725471. 7: Vancura A, Rezanka T, Marsálek J, Kristan V, Basarová G. Fatty acids and production of tylosin-like compounds in Streptomyces fradiae. J Basic Microbiol. 1987;27(3):167-71. PubMed PMID: 3625475. 8: Vilches C, Hernandez C, Mendez C, Salas JA. Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus. J Bacteriol. 1992 Jan;174(1):161-5. PubMed PMID: 1530845; PubMed Central PMCID: PMC205690. 9: Zuzulova M, Kleinova D, Proksa B, Fuska J. In vitro activity of tylosin and its derivatives against Ureaplasma urealyticum. Arzneimittelforschung. 1995 Nov;45(11):1222-4. PubMed PMID: 8929244. 10: Mironov VA, Antonova SV, Bobyleva RI, Iustratova LS, Zhirkova LL, Danilenko VN. [Effect of Ca2+ ions on biosynthesis and component composition of tylosin in Streptomyces fradiae]. Antibiot Khimioter. 1997;42(4):3-7. Russian. PubMed PMID: 9182505. 11: Seno ET, Baltz RH. S-Adenosyl-L-methionine: macrocin O-methyltransferase activities in a series of Streptomyces fradiae mutants that produce different levels of the macrolide antibiotic tylosin. Antimicrob Agents Chemother. 1982 May;21(5):758-63. PubMed PMID: 7103455; PubMed Central PMCID: PMC182007.